Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1)

 EMX1_HUMAN              Reviewed;         257 AA.
Q04741; Q0D2P0; Q53T30; Q86XB0;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
04-JAN-2005, sequence version 2.
20-JUN-2018, entry version 147.
RecName: Full=Homeobox protein EMX1;
AltName: Full=Empty spiracles homolog 1;
AltName: Full=Empty spiracles-like protein 1;
Name=EMX1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 105-257.
PubMed=1352754;
Simeone A., Gulisano M., Acampora D., Stornaiuolo A., Rambaldi M.,
Boncinelli E.;
"Two vertebrate homeobox genes related to the Drosophila empty
spiracles gene are expressed in the embryonic cerebral cortex.";
EMBO J. 11:2541-2550(1992).
[4]
SUBCELLULAR LOCATION, AND INTERACTION WITH WRD11.
PubMed=20887964; DOI=10.1016/j.ajhg.2010.08.018;
Kim H.G., Ahn J.W., Kurth I., Ullmann R., Kim H.T., Kulharya A.,
Ha K.S., Itokawa Y., Meliciani I., Wenzel W., Lee D., Rosenberger G.,
Ozata M., Bick D.P., Sherins R.J., Nagase T., Tekin M., Kim S.H.,
Kim C.H., Ropers H.H., Gusella J.F., Kalscheuer V., Choi C.Y.,
Layman L.C.;
"WDR11, a WD protein that interacts with transcription factor EMX1, is
mutated in idiopathic hypogonadotropic hypogonadism and Kallmann
syndrome.";
Am. J. Hum. Genet. 87:465-479(2010).
-!- FUNCTION: Transcription factor, which in cooperation with EMX2,
acts to generate the boundary between the roof and archipallium in
the developing brain. May function in combinations with OTX1/2 to
specify cell fates in the developing central nervous system.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00108, ECO:0000269|PubMed:20887964}. Cytoplasm
{ECO:0000269|PubMed:20887964}. Note=Might be shuttling between the
nucleus and the cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q04741-1; Sequence=Displayed;
Name=2;
IsoId=Q04741-2; Sequence=VSP_022145, VSP_022146;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Cerebral cortex.
-!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH45762.2; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AC012366; AAY14744.1; -; Genomic_DNA.
EMBL; BC037242; AAH37242.1; -; mRNA.
EMBL; BC045762; AAH45762.2; ALT_INIT; mRNA.
EMBL; X68879; CAA48750.1; -; mRNA.
PIR; S22721; S22721.
RefSeq; NP_004088.2; NM_004097.2.
RefSeq; XP_011530999.1; XM_011532697.2. [Q04741-2]
UniGene; Hs.516090; -.
ProteinModelPortal; Q04741; -.
SMR; Q04741; -.
BioGrid; 108331; 7.
STRING; 9606.ENSP00000258106; -.
EPD; Q04741; -.
PaxDb; Q04741; -.
PeptideAtlas; Q04741; -.
PRIDE; Q04741; -.
ProteomicsDB; 58275; -.
ProteomicsDB; 58276; -. [Q04741-2]
Ensembl; ENST00000258106; ENSP00000258106; ENSG00000135638.
GeneID; 2016; -.
KEGG; hsa:2016; -.
UCSC; uc002sin.1; human. [Q04741-1]
CTD; 2016; -.
DisGeNET; 2016; -.
EuPathDB; HostDB:ENSG00000135638.13; -.
GeneCards; EMX1; -.
HGNC; HGNC:3340; EMX1.
HPA; HPA006230; -.
HPA; HPA006421; -.
MIM; 600034; gene.
neXtProt; NX_Q04741; -.
PharmGKB; PA27777; -.
eggNOG; KOG0843; Eukaryota.
eggNOG; ENOG4111SRW; LUCA.
HOGENOM; HOG000247032; -.
HOVERGEN; HBG005024; -.
InParanoid; Q04741; -.
KO; K09317; -.
OrthoDB; EOG091G0P41; -.
PhylomeDB; Q04741; -.
TreeFam; TF317015; -.
ChiTaRS; EMX1; human.
GeneWiki; EMX1; -.
GenomeRNAi; 2016; -.
PRO; PR:Q04741; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000135638; -.
CleanEx; HS_EMX1; -.
ExpressionAtlas; Q04741; baseline and differential.
Genevisible; Q04741; HS.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005730; C:nucleolus; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0048854; P:brain morphogenesis; IEA:Ensembl.
GO; GO:0021895; P:cerebral cortex neuron differentiation; IEA:Ensembl.
GO; GO:0021796; P:cerebral cortex regionalization; IEA:Ensembl.
GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0060563; P:neuroepithelial cell differentiation; IEA:Ensembl.
GO; GO:1990138; P:neuron projection extension; IEA:Ensembl.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0060019; P:radial glial cell differentiation; IEA:Ensembl.
GO; GO:0070445; P:regulation of oligodendrocyte progenitor proliferation; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Cytoplasm;
Developmental protein; DNA-binding; Homeobox; Nucleus;
Reference proteome.
CHAIN 1 257 Homeobox protein EMX1.
/FTId=PRO_0000048866.
DNA_BIND 159 218 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
VAR_SEQ 1 138 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_022145.
VAR_SEQ 139 140 FQ -> MV (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_022146.
SEQUENCE 257 AA; 28039 MW; 127B0BE676F14B46 CRC64;
MFQPAAKRGF TIESLVAKDG GTGGGTGGGG AGSHLLAAAA SEEPLRPTAL NYPHPSAAEA
AFVSGFPAAA AAGAGRSLYG GPELVFPEAM NHPALTVHPA HQLGASPLQP PHSFFGAQHR
DPLHFYPWVL RNRFFGHRFQ ASDVPQDGLL LHGPFARKPK RIRTAFSPSQ LLRLERAFEK
NHYVVGAERK QLAGSLSLSE TQVKVWFQNR RTKYKRQKLE EEGPESEQKK KGSHHINRWR
IATKQANGED IDVTSND


Related products :

Catalog number Product name Quantity
EIAAB12930 Empty spiracles homolog 1,Empty spiracles-like protein 1,EMX1,Homeobox protein EMX1,Homo sapiens,Human
EIAAB12931 Empty spiracles homolog 1,Empty spiracles-like protein 1,Emx1,Emx-1,Homeobox protein EMX1,Mouse,Mus musculus
18-003-42071 Homeobox protein EMX2 - Empty spiracles homolog 2; Empty spiracles-like protein 2 Polyclonal 0.05 mg Aff Pur
EIAAB12932 Empty spiracles homolog 2,Empty spiracles-like protein 2,EMX2,Homeobox protein EMX2,Homo sapiens,Human
EIAAB12934 Bos taurus,Bovine,Empty spiracles homolog 2,Empty spiracles-like protein 2,EMX2,Homeobox protein EMX2
EIAAB12933 Empty spiracles homolog 2,Empty spiracles-like protein 2,Emx2,Emx-2,Homeobox protein EMX2,Mouse,Mus musculus
ARP47535_P050 EMX1(empty spiracles homeobox 1) 50 µg
EMX2OS EMX1 Gene empty spiracles homeobox 1
18-272-195547 EMX2 - Rabbit polyclonal to EMX2; Empty spiracles homolog 2; Empty spiracles-like protein 2 Polyclonal 0.05 mg
E14424h Human Empty Spiracles Homeobox Protein 2 ELISA Kit 96T
E14425h Human Empty Spiracles Homeobox Protein 1 ELISA Kit 96T
CSB-EL007656HU Human empty spiracles homeobox 1 (EMX1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL007656MO Mouse empty spiracles homeobox 1 (EMX1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
EN1 EMX2 Gene empty spiracles homeobox 2
GWB-4AA3D3 Anti- EMX2 (empty spiracles homeobox 2) Antibody
27-381 The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 along with EMX2 is related to the 'empty spiracles' gene expressed in the developing D 0.05 mg
CSB-EL007657BO Bovine empty spiracles homeobox 2 (EMX2) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL007657MO Mouse empty spiracles homeobox 2 (EMX2) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL007657HU Human empty spiracles homeobox 2 (EMX2) ELISA kit, Species Human, Sample Type serum, plasma 96T
SD5005-EMPTY Ez_10 Empty Column with filter, with collection tube & O_ring 1000
SD5005-EMPTY EZ-10 Empty Column with filter, with collection tube & O-ring 1000
SD5005-EMPTY EMPTY COLUMN, WITH COLLECTION TUBE AND O_RING (SET) >1000
SD5005-EMPTY EMPTY COLUMN, WITH COLLECTION TUBE AND O_RING (SET) >1000
HC-HAP-EMPTY HAP COLUMNS, OLIGO USE, EMPTY WITH 2 FILTERS >2000
SD5006-EMPTY 96 EMPTY FILTER PLATE 1


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur