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Homeobox protein EMX2 (Empty spiracles homolog 2) (Empty spiracles-like protein 2)

 EMX2_BOVIN              Reviewed;         253 AA.
Q17R00;
01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
25-JUL-2006, sequence version 1.
05-DEC-2018, entry version 95.
RecName: Full=Homeobox protein EMX2;
AltName: Full=Empty spiracles homolog 2;
AltName: Full=Empty spiracles-like protein 2;
Name=EMX2;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Uterus;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcription factor, which in cooperation with EMX2,
acts to generate the boundary between the roof and archipallium in
the developing brain. May function in combinations with OTX1/2 to
specify cell fates in the developing central nervous system (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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EMBL; BC118094; AAI18095.1; -; mRNA.
RefSeq; NP_001069313.1; NM_001075845.1.
UniGene; Bt.27308; -.
ProteinModelPortal; Q17R00; -.
SMR; Q17R00; -.
STRING; 9913.ENSBTAP00000003937; -.
PaxDb; Q17R00; -.
PRIDE; Q17R00; -.
Ensembl; ENSBTAT00000003937; ENSBTAP00000003937; ENSBTAG00000003027.
GeneID; 523601; -.
KEGG; bta:523601; -.
CTD; 2018; -.
VGNC; VGNC:28486; EMX2.
eggNOG; KOG0843; Eukaryota.
eggNOG; ENOG4111SRW; LUCA.
GeneTree; ENSGT00940000157425; -.
HOGENOM; HOG000247032; -.
HOVERGEN; HBG005024; -.
InParanoid; Q17R00; -.
KO; K09317; -.
OMA; FQPTPKR; -.
OrthoDB; EOG091G0P41; -.
TreeFam; TF317015; -.
Proteomes; UP000009136; Chromosome 26.
Bgee; ENSBTAG00000003027; Expressed in 7 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0021846; P:cell proliferation in forebrain; IEA:Ensembl.
GO; GO:0021796; P:cerebral cortex regionalization; IEA:Ensembl.
GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
GO; GO:0021885; P:forebrain cell migration; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0072001; P:renal system development; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
InterPro; IPR000047; HTH_motif.
Pfam; PF00046; Homeodomain; 1.
PRINTS; PR00024; HOMEOBOX.
PRINTS; PR00031; HTHREPRESSR.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Reference proteome.
CHAIN 1 253 Homeobox protein EMX2.
/FTId=PRO_0000285082.
DNA_BIND 155 214 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 54 60 Poly-Ala.
SEQUENCE 253 AA; 28344 MW; AAE6D2F46786B21E CRC64;
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAA
GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL PSSHSPHPLF ASQQRDPSTF
YPWLIHRYRY LGHRFQGNDA SPESFLLHNA LARKPKRIRT AFSPSQLLRL EHAFEKNHYV
VGAERKQLAH SLSLTETQVK VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK
QASPEEIDVT SDD


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