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Homeobox protein Hox-A1 (Early retinoic acid 1) (Homeobox protein Hox-1.6) (Homeoboxless protein ERA-1-399) (Homeotic protein ERA-1-993)

 HXA1_MOUSE              Reviewed;         331 AA.
P09022; P15463;
01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 2.
28-MAR-2018, entry version 157.
RecName: Full=Homeobox protein Hox-A1;
AltName: Full=Early retinoic acid 1;
AltName: Full=Homeobox protein Hox-1.6;
AltName: Full=Homeoboxless protein ERA-1-399;
AltName: Full=Homeotic protein ERA-1-993;
Name=Hoxa1; Synonyms=Era-1, Hox-1.6, Hoxa-1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2906112; DOI=10.1128/MCB.8.9.3906;
Larosa G.J., Gudas L.J.;
"Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1:
alternate splicing creates transcripts for a homeobox-containing
protein and one lacking the homeobox.";
Mol. Cell. Biol. 8:3906-3917(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-331.
PubMed=2891503;
Baron A., Featherstone M.S., Hill R.E., Hall A., Galliott B.,
Duboule D.;
"Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1
complex.";
EMBO J. 6:2977-2986(1987).
[3]
DEVELOPMENTAL STAGE.
PubMed=2569969;
Duboule D., Dolle P.;
"The structural and functional organization of the murine HOX gene
family resembles that of Drosophila homeotic genes.";
EMBO J. 8:1497-1505(1989).
-!- FUNCTION: Sequence-specific transcription factor which is part of
a developmental regulatory system that provides cells with
specific positional identities on the anterior-posterior axis.
Acts on the anterior body structures. Seems to act in the
maintenance and/or generation of hindbrain segments.
-!- FUNCTION: The homeobox domain presumably directs sequence-specific
DNA binding. The N-terminal portion of ERA-1-993 may be involved
in interactions with one or more other regulatory proteins. Such
an interaction could regulate either the DNA-binding activity or
the transcriptional regulatory activity of ERA-1-993.
-!- FUNCTION: The homeoboxless ERA-1-399 protein could act as a
competitive inhibitor of the ERA-1-993 protein by competing for
interaction with regulatory protein(s) while being unable to bind
to DNA.
-!- INTERACTION:
Q96GS6:ABHD17A (xeno); NbExp=3; IntAct=EBI-3957603, EBI-2870273;
Q6UY14:ADAMTSL4 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-742002;
Q6P1W5:C1orf94 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-946029;
Q9BSW2:CRACR2A (xeno); NbExp=3; IntAct=EBI-3957603, EBI-739773;
O95967:EFEMP2 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-743414;
Q5TD97:FHL5 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-750641;
P28799:GRN (xeno); NbExp=2; IntAct=EBI-3957603, EBI-747754;
P49639:HOXA1 (xeno); NbExp=4; IntAct=EBI-3957603, EBI-740785;
P31249:HOXD3 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3957655;
Q9UKS7:IKZF2 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3893057;
Q14533:KRT81 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-739648;
Q6PEX3:KRTAP26-1 (xeno); NbExp=4; IntAct=EBI-3957603, EBI-3957672;
Q9BYR7:KRTAP3-2 (xeno); NbExp=4; IntAct=EBI-3957603, EBI-751260;
Q9BQ66:KRTAP4-12 (xeno); NbExp=4; IntAct=EBI-3957603, EBI-739863;
P26371:KRTAP5-9 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3958099;
Q9UHV8:LGALS13 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3957707;
P48059:LIMS1 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-306928;
Q8N448:LNX2 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-2340947;
O60711:LPXN (xeno); NbExp=3; IntAct=EBI-3957603, EBI-744222;
Q99750:MDFI (xeno); NbExp=3; IntAct=EBI-3957603, EBI-724076;
Q3V5L5:MGAT5B (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3957727;
Q92802:N4BP2L2 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-2514973;
O15294:OGT (xeno); NbExp=3; IntAct=EBI-3957603, EBI-539828;
Q8WUM4:PDCD6IP (xeno); NbExp=3; IntAct=EBI-3957603, EBI-310624;
Q9NR12:PDLIM7 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-350517;
Q99697:PITX2 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-1175211;
O15162:PLSCR1 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-740019;
Q9NRQ2:PLSCR4 (xeno); NbExp=4; IntAct=EBI-3957603, EBI-769257;
Q9GZV8:PRDM14 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3957793;
Q5JSZ5:PRRC2B (xeno); NbExp=3; IntAct=EBI-3957603, EBI-744891;
Q14088:RAB33A (xeno); NbExp=3; IntAct=EBI-3957603, EBI-744685;
Q9BYM8:RBCK1 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-2340624;
Q93062:RBPMS (xeno); NbExp=3; IntAct=EBI-3957603, EBI-740322;
O76081:RGS20 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-1052678;
Q8IYX7:SAXO1 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3957636;
Q9H4F8:SMOC1 (xeno); NbExp=2; IntAct=EBI-3957603, EBI-2801103;
O43609:SPRY1 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-3866665;
Q13077:TRAF1 (xeno); NbExp=4; IntAct=EBI-3957603, EBI-359224;
Q12933:TRAF2 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-355744;
O75865:TRAPPC6A (xeno); NbExp=3; IntAct=EBI-3957603, EBI-743573;
P36406:TRIM23 (xeno); NbExp=2; IntAct=EBI-3957603, EBI-740098;
Q15654:TRIP6 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-742327;
Q05516:ZBTB16 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-711925;
Q9Y2Y4:ZBTB32 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-954098;
Q8IYH5:ZZZ3 (xeno); NbExp=3; IntAct=EBI-3957603, EBI-2795524;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=ERA-1-993;
IsoId=P09022-1; Sequence=Displayed;
Name=ERA-1-399;
IsoId=P09022-2; Sequence=VSP_002380, VSP_002381;
-!- DEVELOPMENTAL STAGE: Expressed along the entire length of the
primitive streak. In early neurogenesis it is expressed in lateral
and paraxial mesoderm, endoderm and superficial ectoderm or in the
neural tube. From late neurogenesis to mid-embryogenesis, it
presents similar spatial domains in the lateral mesoderm, endoderm
and superficial ectoderm but is not detectable in any part of the
hindbrain. At day 8-8.5 post-coitum found in the embryonic
mesoderm, anterior to the first somite, up to the cephalic region
at the level of the foregut and developing heart. At day 9 post-
coitum found in an anterior part of the developing foregut and is
restricted to an epithelial cell type. Expression in the gut is
found at the level of the second to third branchial bars.
{ECO:0000269|PubMed:2569969}.
-!- INDUCTION: By retinoic acid.
-!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M22115; AAA37559.1; -; mRNA.
EMBL; M22115; AAA37558.1; -; mRNA.
EMBL; X06023; CAA29426.1; -; Genomic_DNA.
EMBL; X06024; CAA29427.1; -; Genomic_DNA.
EMBL; M20214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; M20216; AAA37839.1; -; Genomic_DNA.
EMBL; M20215; AAA37839.1; JOINED; Genomic_DNA.
PIR; A27155; A27155.
PIR; A30242; A30242.
PIR; B30242; B30242.
UniGene; Mm.197; -.
ProteinModelPortal; P09022; -.
SMR; P09022; -.
DIP; DIP-59869N; -.
IntAct; P09022; 62.
STRING; 10090.ENSMUSP00000000964; -.
PaxDb; P09022; -.
PRIDE; P09022; -.
MGI; MGI:96170; Hoxa1.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
HOGENOM; HOG000171545; -.
HOVERGEN; HBG006089; -.
InParanoid; P09022; -.
PRO; PR:P09022; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_HOXA1; -.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
GO; GO:0021599; P:abducens nerve formation; ISO:MGI.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IGI:MGI.
GO; GO:0009653; P:anatomical structure morphogenesis; IGI:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0060840; P:artery development; ISO:MGI.
GO; GO:0048844; P:artery morphogenesis; ISO:MGI.
GO; GO:0071361; P:cellular response to ethanol; IEP:MGI.
GO; GO:0071300; P:cellular response to retinoic acid; IDA:MGI.
GO; GO:0021953; P:central nervous system neuron differentiation; IMP:MGI.
GO; GO:0090102; P:cochlea development; ISO:MGI.
GO; GO:0090103; P:cochlea morphogenesis; ISO:MGI.
GO; GO:0050890; P:cognition; ISO:MGI.
GO; GO:0048702; P:embryonic neurocranium morphogenesis; ISO:MGI.
GO; GO:0021612; P:facial nerve structural organization; IGI:MGI.
GO; GO:0021754; P:facial nucleus development; IMP:MGI.
GO; GO:0030902; P:hindbrain development; IMP:MGI.
GO; GO:0048839; P:inner ear development; ISO:MGI.
GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
GO; GO:0008045; P:motor neuron axon guidance; IGI:MGI.
GO; GO:0007399; P:nervous system development; IMP:MGI.
GO; GO:0050905; P:neuromuscular process; ISO:MGI.
GO; GO:0007634; P:optokinetic behavior; ISO:MGI.
GO; GO:0042473; P:outer ear morphogenesis; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0050795; P:regulation of behavior; ISO:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0021569; P:rhombomere 3 development; IMP:MGI.
GO; GO:0021570; P:rhombomere 4 development; IMP:MGI.
GO; GO:0021571; P:rhombomere 5 development; IMP:MGI.
GO; GO:0060876; P:semicircular canal formation; ISO:MGI.
GO; GO:0007605; P:sensory perception of sound; ISO:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Developmental protein;
DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 331 Homeobox protein Hox-A1.
/FTId=PRO_0000200031.
DNA_BIND 225 284 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 200 205 Antp-type hexapeptide.
COMPBIAS 60 70 Poly-His.
COMPBIAS 138 142 Poly-His.
VAR_SEQ 115 133 VSGGYPPCAPAVYSGNLST -> PPRSLSFPCFRDVFSSAD
L (in isoform ERA-1-399). {ECO:0000305}.
/FTId=VSP_002380.
VAR_SEQ 134 331 Missing (in isoform ERA-1-399).
{ECO:0000305}.
/FTId=VSP_002381.
SEQUENCE 331 AA; 36037 MW; F73E4FFB1C6F15B2 CRC64;
MNSFLEYPIL GSGDSGTCSA RAYPSDHGIT TFQSCAVSAN SCGGDDRFLV GRGVQISSPH
HHHHHHHHHH PQTATYQTSG NLGISYSHSS CGPSYGAQNF SAPYGPYGLN QEADVSGGYP
PCAPAVYSGN LSTPMVQHHH HHQGYAGGTV GSPQYIHHSY GQEQQTLALA TYNNSLSPLH
ASHQEACRSP ASETSSPAQT FDWMKVKRNP PKTGKVGEYG YVGQPNAVRT NFTTKQLTEL
EKEFHFNKYL TRARRVEIAA SLQLNETQVK IWFQNRRMKQ KKREKEGLLP ISPATPPGSD
EKTEESSEKS SPSPSAPSPA SSTSDTLTTS H


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