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Homeobox protein Hox-A4

 HXA4_HETFR              Reviewed;         247 AA.
Q9IA22;
11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
27-SEP-2017, entry version 80.
RecName: Full=Homeobox protein Hox-A4;
Name=HOXA4;
Heterodontus francisci (Horn shark) (Cestracion francisci).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
Elasmobranchii; Galeomorphii; Heterodontoidea; Heterodontiformes;
Heterodontidae; Heterodontus.
NCBI_TaxID=7792;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10677514; DOI=10.1073/pnas.030539697;
Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W.,
Minoshima S., Shimizu N., Wagner G., Ruddle F.;
"Hox cluster genomics in the horn shark, Heterodontus francisci.";
Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000).
-!- FUNCTION: Sequence-specific transcription factor which is part of
a developmental regulatory system that provides cells with
specific positional identities on the anterior-posterior axis.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00108}.
-!- SIMILARITY: Belongs to the Antp homeobox family. Deformed
subfamily. {ECO:0000305}.
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EMBL; AF224262; AAF44642.1; -; Genomic_DNA.
ProteinModelPortal; Q9IA22; -.
SMR; Q9IA22; -.
HOVERGEN; HBG016849; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR017995; Homeobox_antennapedia.
InterPro; IPR001827; Homeobox_Antennapedia_CS.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00025; ANTENNAPEDIA.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00032; ANTENNAPEDIA; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
3: Inferred from homology;
Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
Transcription regulation.
CHAIN 1 247 Homeobox protein Hox-A4.
/FTId=PRO_0000200054.
DNA_BIND 149 208 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 128 133 Antp-type hexapeptide.
SEQUENCE 247 AA; 28408 MW; BE518038CA73D2E6 CRC64;
MTMSSFLINS NYVEPKFPPC EEYSQNNYIP SQSPEYYERP RDPGFHHEAL YPQSNYPEPT
YSFNNVQGTG NQDMSQRGHV QSQASLQNHI PRQNQLCEVV PVATPALCSQ NAKNPTAQKG
TLSKEPIVYP WMKKIHVTTV NPNYTGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI
EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSASS SSSTSQQTQV SSQGPQPDGS
APNSSSL


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