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Homeobox protein Hox-A4 (Homeobox protein Hox-1.4) (Chox-1.4)

 HXA4_CHICK              Reviewed;         309 AA.
P17277;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
22-NOV-2017, entry version 133.
RecName: Full=Homeobox protein Hox-A4;
AltName: Full=Homeobox protein Hox-1.4;
Short=Chox-1.4;
Name=HOXA4; Synonyms=CHOX-1.4;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1970866; DOI=10.1093/nar/18.7.1739;
Sasaki H., Yokoyama E., Kuroiwa A.;
"Specific DNA binding of the two chicken Deformed family homeodomain
proteins, Chox-1.4 and Chox-a.";
Nucleic Acids Res. 18:1739-1747(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 207-273.
STRAIN=Comet Hubbard hybrid;
PubMed=1973835; DOI=10.1093/nar/18.13.3999;
Scotting P.J., Hewitt M., Keynes R.J.;
"Isolation and analysis of chick homeobox cDNA clones.";
Nucleic Acids Res. 18:3999-3999(1990).
-!- FUNCTION: Sequence-specific transcription factor which is part of
a developmental regulatory system that provides cells with
specific positional identities on the anterior-posterior axis.
Binds to sites in the 5'-flanking sequence of its coding region
with various affinities. The consensus sequences of the high and
low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-
3'.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DOMAIN: The proline stretch works as a part of the transcriptional
activation domain.
-!- SIMILARITY: Belongs to the Antp homeobox family. Deformed
subfamily. {ECO:0000305}.
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EMBL; X52670; CAA36896.1; -; mRNA.
EMBL; X52747; CAB57949.1; -; mRNA.
PIR; S09257; S09257.
RefSeq; NP_001025517.1; NM_001030346.1.
UniGene; Gga.4243; -.
ProteinModelPortal; P17277; -.
SMR; P17277; -.
STRING; 9031.ENSGALP00000017984; -.
PaxDb; P17277; -.
Ensembl; ENSGALT00000029853; ENSGALP00000029207; ENSGALG00000022622.
GeneID; 395307; -.
KEGG; gga:395307; -.
CTD; 3201; -.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
GeneTree; ENSGT00900000140772; -.
HOGENOM; HOG000231179; -.
HOVERGEN; HBG016849; -.
InParanoid; P17277; -.
KO; K09304; -.
OMA; YYAPRTA; -.
OrthoDB; EOG091G09XD; -.
PRO; PR:P17277; -.
Proteomes; UP000000539; Chromosome 2.
Bgee; ENSGALG00000011055; -.
GO; GO:0016604; C:nuclear body; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001827; Homeobox_Antennapedia_CS.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00032; ANTENNAPEDIA; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Reference proteome; Transcription; Transcription regulation.
CHAIN 1 309 Homeobox protein Hox-A4.
/FTId=PRO_0000200052.
DNA_BIND 209 268 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 188 193 Antp-type hexapeptide.
COMPBIAS 38 148 Pro-rich.
SEQUENCE 309 AA; 33478 MW; 8898A41502319341 CRC64;
MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP PPPPPHLHAA
HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ APSYPQAPYS YSSAGSAAPG
PEQPPPGASP PPPPPAKGHP GPAQPLLPGH ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG
LKGKEPVVYP WMKKIHVSTV NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI
EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD
GAAPNAAAL


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