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 HXA5_MOUSE              Reviewed;         270 AA.
 P09021; Q91VQ5;
 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
 01-NOV-1988, sequence version 1.
 12-SEP-2018, entry version 155.
 RecName: Full=Homeobox protein Hox-A5;
 AltName: Full=Homeobox protein Hox-1.3;
 AltName: Full=Homeobox protein M2;
 Name=Hoxa5; Synonyms=Hox-1.3, Hoxa-5;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE.
 PubMed=2890554; DOI=10.1101/gad.1.5.482;
 Odenwald W.F., Taylor C.F., Palmer-Hill F.J., Friedrich V. Jr.,
 Tani M., Lazzarini R.A.;
 "Expression of a homeo domain protein in noncontact-inhibited cultured
 cells and postmitotic neurons.";
 Genes Dev. 1:482-496(1987).
 [2]
 NUCLEOTIDE SEQUENCE.
 PubMed=2901335;
 Fibi M., Zink B., Kessel M., Colberg-Poley A.M., Labeit S.,
 Lehrach H., Gruss P.;
 "Coding sequence and expression of the homeobox gene Hox 1.3.";
 Development 102:349-359(1988).
 [3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 STRAIN=FVB/N; TISSUE=Mammary tumor;
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA
 project: the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 [4]
 DNA-BINDING SPECIFICITY.
 PubMed=2565857; DOI=10.1101/gad.3.2.158;
 Odenwald W.F., Garbern J., Arnheiter H., Tournier-Lasserve E.,
 Lazzarini R.A.;
 "The Hox-1.3 homeo box protein is a sequence-specific DNA-binding
 phosphoprotein.";
 Genes Dev. 3:158-172(1989).
 [5]
 CHARACTERIZATION.
 PubMed=8635464;
 Zhao J.J., Lazzarini R.A., Pick L.;
 "Functional dissection of the mouse Hox-a5 gene.";
 EMBO J. 15:1313-1322(1996).
 -!- FUNCTION: Sequence-specific transcription factor which is part of
     a developmental regulatory system that provides cells with
     specific positional identities on the anterior-posterior axis.
     Also binds to its own promoter. Binds specifically to the motif
     5'-CYYNATTA[TG]Y-3'.
 -!- SUBCELLULAR LOCATION: Nucleus.
 -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis and in adult
     kidney.
 -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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 EMBL; M36604; AAA37838.1; -; mRNA.
 EMBL; Y00208; CAA68364.1; -; Genomic_DNA.
 EMBL; X16840; CAA34738.1; -; mRNA.
 EMBL; M28021; AAA37837.1; -; mRNA.
 EMBL; BC011063; AAH11063.1; -; mRNA.
 CCDS; CCDS20143.1; -.
 PIR; S07812; WJMS13.
 RefSeq; NP_034583.1; NM_010453.5.
 UniGene; Mm.173; -.
 ProteinModelPortal; P09021; -.
 SMR; P09021; -.
 BioGrid; 200370; 1.
 IntAct; P09021; 3.
 MINT; P09021; -.
 STRING; 10090.ENSMUSP00000039012; -.
 PhosphoSitePlus; P09021; -.
 MaxQB; P09021; -.
 PaxDb; P09021; -.
 PeptideAtlas; P09021; -.
 PRIDE; P09021; -.
 Ensembl; ENSMUST00000048794; ENSMUSP00000039012; ENSMUSG00000038253.
 GeneID; 15402; -.
 KEGG; mmu:15402; -.
 UCSC; uc009byh.1; mouse.
 CTD; 3202; -.
 MGI; MGI:96177; Hoxa5.
 eggNOG; KOG0489; Eukaryota.
 eggNOG; ENOG410ZTBY; LUCA.
 GeneTree; ENSGT00910000143983; -.
 HOGENOM; HOG000231178; -.
 HOVERGEN; HBG016849; -.
 InParanoid; P09021; -.
 KO; K09305; -.
 OMA; LKSMNMA; -.
 OrthoDB; EOG091G09XD; -.
 PhylomeDB; P09021; -.
 TreeFam; TF316310; -.
 PRO; PR:P09021; -.
 Proteomes; UP000000589; Chromosome 6.
 Bgee; ENSMUSG00000038253; Expressed in 223 organ(s), highest expression level in efferent duct.
 CleanEx; MM_HOXA5; -.
 Genevisible; P09021; MM.
 GO; GO:0005634; C:nucleus; IDA:MGI.
 GO; GO:0003677; F:DNA binding; IDA:MGI.
 GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
 GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
 GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
 GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO; GO:0060435; P:bronchiole development; IMP:MGI.
 GO; GO:0060536; P:cartilage morphogenesis; IMP:MGI.
 GO; GO:0016477; P:cell migration; IMP:MGI.
 GO; GO:0060764; P:cell-cell signaling involved in mammary gland development; IMP:MGI.
 GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
 GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
 GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IMP:MGI.
 GO; GO:0060574; P:intestinal epithelial cell maturation; IMP:MGI.
 GO; GO:0060481; P:lobar bronchus epithelium development; IMP:MGI.
 GO; GO:0048286; P:lung alveolus development; IMP:MGI.
 GO; GO:0030324; P:lung development; IMP:MGI.
 GO; GO:0060480; P:lung goblet cell differentiation; IMP:MGI.
 GO; GO:0060484; P:lung-associated mesenchyme development; IMP:MGI.
 GO; GO:0060749; P:mammary gland alveolus development; IMP:MGI.
 GO; GO:0060644; P:mammary gland epithelial cell differentiation; IMP:MGI.
 GO; GO:0060638; P:mesenchymal-epithelial cell signaling; IMP:MGI.
 GO; GO:0002009; P:morphogenesis of an epithelium; IMP:MGI.
 GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO; GO:0016525; P:negative regulation of angiogenesis; ISO:MGI.
 GO; GO:0045647; P:negative regulation of erythrocyte differentiation; ISO:MGI.
 GO; GO:0007389; P:pattern specification process; IMP:MGI.
 GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
 GO; GO:0045639; P:positive regulation of myeloid cell differentiation; ISO:MGI.
 GO; GO:0010870; P:positive regulation of receptor biosynthetic process; ISO:MGI.
 GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
 GO; GO:0033599; P:regulation of mammary gland epithelial cell proliferation; IMP:MGI.
 GO; GO:0007585; P:respiratory gaseous exchange; IMP:MGI.
 GO; GO:0003016; P:respiratory system process; IMP:MGI.
 GO; GO:0001501; P:skeletal system development; IMP:MGI.
 GO; GO:0030878; P:thyroid gland development; IMP:MGI.
 GO; GO:0060535; P:trachea cartilage morphogenesis; IMP:MGI.
 GO; GO:0060439; P:trachea morphogenesis; IMP:MGI.
 CDD; cd00086; homeodomain; 1.
 InterPro; IPR009057; Homeobox-like_sf.
 InterPro; IPR017995; Homeobox_antennapedia.
 InterPro; IPR001827; Homeobox_Antennapedia_CS.
 InterPro; IPR017970; Homeobox_CS.
 InterPro; IPR001356; Homeobox_dom.
 InterPro; IPR020479; Homeobox_metazoa.
 Pfam; PF00046; Homeobox; 1.
 PRINTS; PR00025; ANTENNAPEDIA.
 PRINTS; PR00024; HOMEOBOX.
 SMART; SM00389; HOX; 1.
 SUPFAM; SSF46689; SSF46689; 1.
 PROSITE; PS00032; ANTENNAPEDIA; 1.
 PROSITE; PS00027; HOMEOBOX_1; 1.
 PROSITE; PS50071; HOMEOBOX_2; 1.
 1: Evidence at protein level;
 Complete proteome; Developmental protein; DNA-binding; Homeobox;
 Nucleus; Reference proteome; Transcription; Transcription regulation.
 CHAIN         1    270       Homeobox protein Hox-A5.
                              /FTId=PRO_0000200058.
 DNA_BIND    195    254       Homeobox. {ECO:0000255|PROSITE-
                              ProRule:PRU00108}.
 MOTIF       176    181       Antp-type hexapeptide.
 CONFLICT     70     70       A -> V (in Ref. 3; AAH11063).
                              {ECO:0000305}.
 SEQUENCE   270 AA;  29237 MW;  DC4BDDA8FE62766E CRC64;
 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG
 SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN
 SLGNSSGASA NAGSTHISSR EGVGTASAAE EDAPASSEQA GAQSEPSPAP PAQPQIYPWM
 RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK
 IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP

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