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Homeobox protein Hox-B2 (Homeobox protein Hox-2.8) (Homeobox protein Hox-2H) (K8)

 HXB2_HUMAN              Reviewed;         356 AA.
P14652; P10913; P17485;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
05-DEC-2018, entry version 175.
RecName: Full=Homeobox protein Hox-B2;
AltName: Full=Homeobox protein Hox-2.8;
AltName: Full=Homeobox protein Hox-2H;
AltName: Full=K8;
Name=HOXB2; Synonyms=HOX2H;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2574852; DOI=10.1093/nar/17.24.10385;
Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E.,
Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.;
"The human HOX gene family.";
Nucleic Acids Res. 17:10385-10402(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-208.
TISSUE=Placenta;
PubMed=2570724; DOI=10.1111/j.1432-0436.1989.tb00598.x;
Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M.,
Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A.,
Boncinelli E., Peschle C.;
"Differential expression of human HOX-2 genes along the anterior-
posterior axis in embryonic central nervous system.";
Differentiation 40:191-197(1989).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-208.
PubMed=2576652;
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
"Organization of human class I homeobox genes.";
Genome 31:745-756(1989).
[5]
NUCLEOTIDE SEQUENCE OF 143-202.
PubMed=2901346;
Kongsuwan K., Webb E., Housiaux P., Adams J.M.;
"Expression of multiple homeobox genes within diverse mammalian
haemopoietic lineages.";
EMBO J. 7:2131-2138(1988).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
PubMed=7876223; DOI=10.1074/jbc.270.9.4544;
Vieille-Grosjean I., Huber P.;
"Transcription factor GATA-1 regulates human HOXB2 gene expression in
erythroid cells.";
J. Biol. Chem. 270:4544-4550(1995).
[7]
FUNCTION, AND GAMMA-GLOBIN PROMOTER AND ENHANCER BINDING FACTOR
COMPLEX.
PubMed=10595394; DOI=10.1089/104454999314809;
Case S.S., Huber P., Lloyd J.A.;
"The gammaPE complex contains both SATB1 and HOXB2 and has positive
and negative roles in human gamma-globin gene regulation.";
DNA Cell Biol. 18:805-817(1999).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
-!- FUNCTION: Sequence-specific transcription factor which is part of
a developmental regulatory system that provides cells with
specific positional identities on the anterior-posterior axis.
{ECO:0000269|PubMed:10595394}.
-!- SUBUNIT: Part of the nuclear protein complex gamma-globin promoter
and enhancer binding factor (gamma-PE) composed at least by SATB1
and HOXB2.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9
weeks from conception.
-!- SIMILARITY: Belongs to the Antp homeobox family. Proboscipedia
subfamily. {ECO:0000305}.
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EMBL; X16665; CAA34655.1; -; mRNA.
EMBL; BC074805; AAH74805.1; -; mRNA.
EMBL; BC074806; AAH74806.1; -; mRNA.
EMBL; X16176; CAA34298.1; -; Genomic_DNA.
EMBL; X14571; CAA32709.1; -; mRNA.
EMBL; X78978; CAA55581.1; -; Genomic_DNA.
CCDS; CCDS11527.1; -.
PIR; S07542; WJHU2H.
RefSeq; NP_002136.1; NM_002145.3.
UniGene; Hs.514289; -.
ProteinModelPortal; P14652; -.
SMR; P14652; -.
BioGrid; 109452; 1.
ELM; P14652; -.
IntAct; P14652; 9.
STRING; 9606.ENSP00000331741; -.
iPTMnet; P14652; -.
PhosphoSitePlus; P14652; -.
BioMuta; HOXB2; -.
DMDM; 123270; -.
PaxDb; P14652; -.
PeptideAtlas; P14652; -.
PRIDE; P14652; -.
ProteomicsDB; 53071; -.
DNASU; 3212; -.
Ensembl; ENST00000330070; ENSP00000331741; ENSG00000173917.
GeneID; 3212; -.
KEGG; hsa:3212; -.
UCSC; uc002inm.5; human.
CTD; 3212; -.
DisGeNET; 3212; -.
EuPathDB; HostDB:ENSG00000173917.10; -.
GeneCards; HOXB2; -.
HGNC; HGNC:5113; HOXB2.
HPA; HPA047857; -.
MIM; 142967; gene.
neXtProt; NX_P14652; -.
OpenTargets; ENSG00000173917; -.
PharmGKB; PA29389; -.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
GeneTree; ENSGT00940000155029; -.
HOGENOM; HOG000063664; -.
HOVERGEN; HBG006088; -.
InParanoid; P14652; -.
KO; K09302; -.
OMA; HEFPWMK; -.
OrthoDB; EOG091G0IJ4; -.
PhylomeDB; P14652; -.
TreeFam; TF317730; -.
Reactome; R-HSA-5617472; Activation of anterior HOX genes in hindbrain development during early embryogenesis.
GeneWiki; HOXB2; -.
GenomeRNAi; 3212; -.
PRO; PR:P14652; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000173917; Expressed in 163 organ(s), highest expression level in caput epididymis.
CleanEx; HS_HOXB2; -.
Genevisible; P14652; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0016607; C:nuclear speck; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:HPA.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IC:NTNU_SB.
GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0008015; P:blood circulation; TAS:ProtInc.
GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
GO; GO:0021612; P:facial nerve structural organization; IEA:Ensembl.
GO; GO:0002011; P:morphogenesis of an epithelial sheet; IEA:Ensembl.
GO; GO:0007275; P:multicellular organism development; TAS:ProtInc.
GO; GO:0048857; P:neural nucleus development; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
GO; GO:0021569; P:rhombomere 3 development; IEA:Ensembl.
GO; GO:0021570; P:rhombomere 4 development; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001827; Homeobox_Antennapedia_CS.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeodomain; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00032; ANTENNAPEDIA; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 356 Homeobox protein Hox-B2.
/FTId=PRO_0000200114.
DNA_BIND 143 202 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 94 99 Antp-type hexapeptide.
MOD_RES 274 274 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
CONFLICT 136 138 PEA -> RRL (in Ref. 3; CAA34298).
{ECO:0000305}.
SEQUENCE 356 AA; 37914 MW; D7ACA0E3D5BEBFB9 CRC64;
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE QTFPSLQPGA
STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE KKSAKKPSQS ATSPSPAASA
VPASGVGSPA DGLGLPEAGG GGARRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL
DLTERQVKVW FQNRRMKHKR QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA
AWEACCHPPE VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD
SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA IDLQFP


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