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Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2)

 MEOX2_HUMAN             Reviewed;         304 AA.
P50222; A4D127; B2R8I7; O75263; Q9UPL6;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
18-APR-2006, sequence version 2.
22-NOV-2017, entry version 160.
RecName: Full=Homeobox protein MOX-2;
AltName: Full=Growth arrest-specific homeobox;
AltName: Full=Mesenchyme homeobox 2;
Name=MEOX2; Synonyms=GAX, MOX2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT HIS-80 DEL.
TISSUE=Embryo;
PubMed=7607679; DOI=10.1016/0888-7543(95)80174-K;
Grigoriou M., Kastrinaki M.-C., Modi W., Theodorakis K., Mankoo B.,
Pachnis V., Karagogeos D.;
"Isolation of the human MOX2 homeobox gene and localization to
chromosome 7p22.1-p21.3.";
Genomics 26:550-555(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT 79-HIS-HIS-80 DEL.
TISSUE=Heart;
PubMed=7713505; DOI=10.1006/geno.1994.1663;
Lepage D.F., Walsh K.;
"Molecular cloning and localization of the human GAX gene to 7p21.";
Genomics 24:535-540(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-80 DEL.
TISSUE=Trachea;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12853948; DOI=10.1038/nature01782;
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT HIS-80 DEL.
PubMed=12690205; DOI=10.1126/science.1083423;
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
Mural R.J., Adams M.D., Tsui L.-C.;
"Human chromosome 7: DNA sequence and biology.";
Science 300:767-772(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-80 DEL.
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
INTERACTION WITH RNF10.
PubMed=16335786; DOI=10.1007/s11010-005-0823-3;
Lin J., Friesen M.T., Bocangel P., Cheung D., Rawszer K., Wigle J.T.;
"Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription
factor binding to RING finger protein 10.";
Mol. Cell. Biochem. 275:75-84(2005).
[8]
POLY-HIS POLYMORPHISM.
PubMed=19760604; DOI=10.1002/gcc.20705;
Ohshima J., Haruta M., Arai Y., Kasai F., Fujiwara Y., Ariga T.,
Okita H., Fukuzawa M., Hata J., Horie H., Kaneko Y.;
"Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified
in a 7p21 homozygous deletion region in a Wilms tumor.";
Genes Chromosomes Cancer 48:1037-1050(2009).
[9]
SUBCELLULAR LOCATION.
PubMed=19266028; DOI=10.1371/journal.pgen.1000397;
Salichs E., Ledda A., Mularoni L., Alba M.M., de la Luna S.;
"Genome-wide analysis of histidine repeats reveals their role in the
localization of human proteins to the nuclear speckles compartment.";
PLoS Genet. 5:E1000397-E1000397(2009).
[10]
FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF GLN-236.
PubMed=22206000; DOI=10.1371/journal.pone.0029099;
Douville J.M., Cheung D.Y., Herbert K.L., Moffatt T., Wigle J.T.;
"Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent
kinase inhibitors p21 and p16 in vascular endothelial cells.";
PLoS ONE 6:E29099-E29099(2011).
-!- FUNCTION: Mesodermal transcription factor that plays a key role in
somitogenesis and is required for sclerotome development (By
similarity). Activates expression of CDKN1A and CDKN2A in
endothelial cells, acting as a regulator of vascular cell
proliferation. While it activates CDKN1A in a DNA-dependent
manner, it activates CDKN2A in a DNA-independent manner
(PubMed:22206000). May have a regulatory role when quiescent
vascular smooth muscle cells reenter the cell cycle.
{ECO:0000250|UniProtKB:P32443, ECO:0000269|PubMed:22206000}.
-!- SUBUNIT: Interacts with RNF10. {ECO:0000269|PubMed:16335786}.
-!- INTERACTION:
Q6ZVW3:-; NbExp=3; IntAct=EBI-748397, EBI-10255586;
Q7Z783:-; NbExp=3; IntAct=EBI-748397, EBI-9088990;
Q9NWJ2:-; NbExp=3; IntAct=EBI-748397, EBI-10315029;
O43707:ACTN4; NbExp=3; IntAct=EBI-748397, EBI-351526;
P58397:ADAMTS12; NbExp=3; IntAct=EBI-748397, EBI-9028051;
Q99943:AGPAT1; NbExp=3; IntAct=EBI-748397, EBI-3893468;
O43865:AHCYL1; NbExp=3; IntAct=EBI-748397, EBI-2371423;
Q719I0:AHSA2; NbExp=3; IntAct=EBI-748397, EBI-9361704;
Q92688:ANP32B; NbExp=3; IntAct=EBI-748397, EBI-762428;
Q6P4J0:ARD1A; NbExp=3; IntAct=EBI-748397, EBI-10252815;
Q14155:ARHGEF7; NbExp=3; IntAct=EBI-748397, EBI-717515;
Q9NXU5:ARL15; NbExp=4; IntAct=EBI-748397, EBI-711759;
Q8WYA1-3:ARNTL2; NbExp=4; IntAct=EBI-748397, EBI-12268276;
A9UGY9:ATG5; NbExp=3; IntAct=EBI-748397, EBI-10175276;
O60909-2:B4GALT2; NbExp=4; IntAct=EBI-748397, EBI-12261054;
Q5TBC7:BCL2L15; NbExp=3; IntAct=EBI-748397, EBI-10247136;
Q06187:BTK; NbExp=3; IntAct=EBI-748397, EBI-624835;
Q9NX04:C1orf109; NbExp=5; IntAct=EBI-748397, EBI-8643161;
Q9H257:CARD9; NbExp=3; IntAct=EBI-748397, EBI-751319;
P31944:CASP14; NbExp=3; IntAct=EBI-748397, EBI-2510738;
Q8IW40:CCDC103; NbExp=5; IntAct=EBI-748397, EBI-10261970;
Q8IYE1:CCDC13; NbExp=4; IntAct=EBI-748397, EBI-10961312;
P24863:CCNC; NbExp=5; IntAct=EBI-748397, EBI-395261;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-748397, EBI-10181988;
Q9UKJ5:CHIC2; NbExp=5; IntAct=EBI-748397, EBI-741528;
Q9H2X0:CHRD; NbExp=5; IntAct=EBI-748397, EBI-947551;
P07510-2:CHRNG; NbExp=3; IntAct=EBI-748397, EBI-11979451;
Q6FI81:CIAPIN1; NbExp=3; IntAct=EBI-748397, EBI-750511;
Q96Q77:CIB3; NbExp=7; IntAct=EBI-748397, EBI-10292696;
Q9UHC6:CNTNAP2; NbExp=3; IntAct=EBI-748397, EBI-310892;
Q14055:COL9A2; NbExp=4; IntAct=EBI-748397, EBI-714971;
O95741:CPNE6; NbExp=3; IntAct=EBI-748397, EBI-719005;
Q9UBL6-2:CPNE7; NbExp=4; IntAct=EBI-748397, EBI-12012272;
O95639:CPSF4; NbExp=3; IntAct=EBI-748397, EBI-725860;
Q9UGL9:CRCT1; NbExp=3; IntAct=EBI-748397, EBI-713677;
Q9Y534:CSDC2; NbExp=3; IntAct=EBI-748397, EBI-1763657;
P04141:CSF2; NbExp=6; IntAct=EBI-748397, EBI-1809826;
P68400:CSNK2A1; NbExp=4; IntAct=EBI-748397, EBI-347804;
Q8WYA6:CTNNBL1; NbExp=3; IntAct=EBI-748397, EBI-748128;
Q9P0U4:CXXC1; NbExp=3; IntAct=EBI-748397, EBI-949911;
Q8WYQ5:DGCR8; NbExp=3; IntAct=EBI-748397, EBI-528411;
Q9NVM6:DNAJC17; NbExp=4; IntAct=EBI-748397, EBI-12260682;
Q8NF50:DOCK8; NbExp=3; IntAct=EBI-748397, EBI-2548605;
Q96FJ2:DYNLL2; NbExp=3; IntAct=EBI-748397, EBI-742371;
O60869:EDF1; NbExp=3; IntAct=EBI-748397, EBI-781301;
Q12805:EFEMP1; NbExp=5; IntAct=EBI-748397, EBI-536772;
O95967:EFEMP2; NbExp=3; IntAct=EBI-748397, EBI-743414;
P52797:EFNA3; NbExp=3; IntAct=EBI-748397, EBI-722730;
Q8N9N8:EIF1AD; NbExp=3; IntAct=EBI-748397, EBI-750700;
P63241:EIF5A; NbExp=5; IntAct=EBI-748397, EBI-373150;
Q9NPA0:EMC7; NbExp=4; IntAct=EBI-748397, EBI-6309137;
P50402:EMD; NbExp=5; IntAct=EBI-748397, EBI-489887;
Q7L775:EPM2AIP1; NbExp=7; IntAct=EBI-748397, EBI-6255981;
P62508:ESRRG; NbExp=3; IntAct=EBI-748397, EBI-2834260;
Q8NE31:FAM13C; NbExp=3; IntAct=EBI-748397, EBI-751248;
Q9BU27:FAM3A; NbExp=3; IntAct=EBI-748397, EBI-10298603;
Q5TZK3:FAM74A6; NbExp=5; IntAct=EBI-748397, EBI-10247271;
Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-748397, EBI-10244131;
Q9UBX5:FBLN5; NbExp=3; IntAct=EBI-748397, EBI-947897;
O75344:FKBP6; NbExp=5; IntAct=EBI-748397, EBI-744771;
Q6PIV2:FOXR1; NbExp=3; IntAct=EBI-748397, EBI-10253815;
Q9BTY2:FUCA2; NbExp=3; IntAct=EBI-748397, EBI-9050116;
Q495W5:FUT11; NbExp=3; IntAct=EBI-748397, EBI-2907712;
Q13065:GAGE1; NbExp=3; IntAct=EBI-748397, EBI-10227730;
P36383:GJC1; NbExp=4; IntAct=EBI-748397, EBI-11979659;
Q8NEA9:GMCL1P1; NbExp=5; IntAct=EBI-748397, EBI-745707;
Q6PKC0:GMPR2; NbExp=3; IntAct=EBI-748397, EBI-10254128;
Q53Y01:GNG11; NbExp=3; IntAct=EBI-748397, EBI-10243023;
Q0D2H9:GOLGA8DP; NbExp=5; IntAct=EBI-748397, EBI-10181276;
Q08AF8:GOLGA8G; NbExp=3; IntAct=EBI-748397, EBI-10181260;
Q9NWQ4:GPATCH2L; NbExp=3; IntAct=EBI-748397, EBI-5666657;
Q9Y4H4:GPSM3; NbExp=3; IntAct=EBI-748397, EBI-347538;
O14929:HAT1; NbExp=5; IntAct=EBI-748397, EBI-2339359;
O14929-2:HAT1; NbExp=3; IntAct=EBI-748397, EBI-10181798;
Q9H0R4:HDHD2; NbExp=3; IntAct=EBI-748397, EBI-10304657;
Q96MH2:HEXIM2; NbExp=5; IntAct=EBI-748397, EBI-5460660;
P14210:HGF; NbExp=3; IntAct=EBI-748397, EBI-1039104;
P04440:HLA-DPB1; NbExp=4; IntAct=EBI-748397, EBI-2802503;
Q86VS8:HOOK3; NbExp=4; IntAct=EBI-748397, EBI-1777078;
Q5SSJ5:HP1BP3; NbExp=3; IntAct=EBI-748397, EBI-2880687;
P28566:HTR1E; NbExp=3; IntAct=EBI-748397, EBI-1043151;
Q86VF2:IGFN1; NbExp=3; IntAct=EBI-748397, EBI-10259767;
P01583:IL1A; NbExp=3; IntAct=EBI-748397, EBI-1749782;
Q9UHH9:IP6K2; NbExp=3; IntAct=EBI-748397, EBI-747509;
O43736:ITM2A; NbExp=3; IntAct=EBI-748397, EBI-2431769;
Q9BX67:JAM3; NbExp=4; IntAct=EBI-748397, EBI-4314733;
Q92993:KAT5; NbExp=3; IntAct=EBI-748397, EBI-399080;
Q2M2Z5:KIZ; NbExp=3; IntAct=EBI-748397, EBI-2554344;
Q9NSK0:KLC4; NbExp=3; IntAct=EBI-748397, EBI-949319;
Q2WGJ6:KLHL38; NbExp=3; IntAct=EBI-748397, EBI-6426443;
Q6KB66:KRT80; NbExp=3; IntAct=EBI-748397, EBI-3046635;
O43790:KRT86; NbExp=3; IntAct=EBI-748397, EBI-9996498;
P60412:KRTAP10-11; NbExp=5; IntAct=EBI-748397, EBI-10217483;
P60370:KRTAP10-5; NbExp=5; IntAct=EBI-748397, EBI-10172150;
P60410:KRTAP10-8; NbExp=5; IntAct=EBI-748397, EBI-10171774;
P60411:KRTAP10-9; NbExp=6; IntAct=EBI-748397, EBI-10172052;
P59990:KRTAP12-1; NbExp=5; IntAct=EBI-748397, EBI-10210845;
P60329:KRTAP12-4; NbExp=5; IntAct=EBI-748397, EBI-10176396;
Q9BYQ6:KRTAP4-11; NbExp=5; IntAct=EBI-748397, EBI-10302392;
Q9BQ66:KRTAP4-12; NbExp=3; IntAct=EBI-748397, EBI-739863;
Q9BYR5:KRTAP4-2; NbExp=5; IntAct=EBI-748397, EBI-10172511;
Q9BYR0:KRTAP4-7; NbExp=3; IntAct=EBI-748397, EBI-10302547;
Q6L8G9:KRTAP5-6; NbExp=5; IntAct=EBI-748397, EBI-10250562;
P26371:KRTAP5-9; NbExp=5; IntAct=EBI-748397, EBI-3958099;
Q9BYQ4:KRTAP9-2; NbExp=5; IntAct=EBI-748397, EBI-1044640;
Q86UP2:KTN1; NbExp=3; IntAct=EBI-748397, EBI-359761;
A0A0C4DGV4:LAMTOR5; NbExp=3; IntAct=EBI-748397, EBI-10173304;
O43561-2:LAT; NbExp=4; IntAct=EBI-748397, EBI-8070286;
Q5T7P3:LCE1B; NbExp=3; IntAct=EBI-748397, EBI-10245913;
Q5TA79:LCE2A; NbExp=5; IntAct=EBI-748397, EBI-10246607;
Q5TA78:LCE4A; NbExp=3; IntAct=EBI-748397, EBI-10246358;
Q9Y333:LSM2; NbExp=3; IntAct=EBI-748397, EBI-347416;
Q9Y5V3:MAGED1; NbExp=3; IntAct=EBI-748397, EBI-716006;
O60336:MAPKBP1; NbExp=5; IntAct=EBI-748397, EBI-947402;
P53582:METAP1; NbExp=4; IntAct=EBI-748397, EBI-1051435;
Q6NSB6:MKRN3; NbExp=3; IntAct=EBI-748397, EBI-10195599;
Q6P2C6:MLLT6; NbExp=3; IntAct=EBI-748397, EBI-5773143;
P08254:MMP3; NbExp=3; IntAct=EBI-748397, EBI-6957351;
Q6PF18:MORN3; NbExp=3; IntAct=EBI-748397, EBI-9675802;
Q96HT8:MRFAP1L1; NbExp=3; IntAct=EBI-748397, EBI-748896;
Q96DH6:MSI2; NbExp=3; IntAct=EBI-748397, EBI-2462339;
A1L3X4:MT1DP; NbExp=5; IntAct=EBI-748397, EBI-10172129;
Q9H6H2:MUM1; NbExp=3; IntAct=EBI-748397, EBI-10307610;
P41227:NAA10; NbExp=5; IntAct=EBI-748397, EBI-747693;
Q8IZF0:NALCN; NbExp=3; IntAct=EBI-748397, EBI-7085333;
P61601:NCALD; NbExp=3; IntAct=EBI-748397, EBI-749635;
O43639:NCK2; NbExp=3; IntAct=EBI-748397, EBI-713635;
P20783:NTF3; NbExp=3; IntAct=EBI-748397, EBI-1025994;
Q14990:ODF1; NbExp=4; IntAct=EBI-748397, EBI-10234557;
Q8WWZ8:OIT3; NbExp=5; IntAct=EBI-748397, EBI-10277776;
Q99784-3:OLFM1; NbExp=4; IntAct=EBI-748397, EBI-12304423;
Q9UJX0:OSGIN1; NbExp=3; IntAct=EBI-748397, EBI-9057006;
Q7Z4N8:P4HA3; NbExp=3; IntAct=EBI-748397, EBI-10181968;
Q9UNF0:PACSIN2; NbExp=5; IntAct=EBI-748397, EBI-742503;
Q7Z2X7:PAGE2; NbExp=3; IntAct=EBI-748397, EBI-10256818;
Q9NWT1:PAK1IP1; NbExp=4; IntAct=EBI-748397, EBI-7641942;
Q9HBI0:PARVG; NbExp=5; IntAct=EBI-748397, EBI-3921217;
Q92824:PCSK5; NbExp=3; IntAct=EBI-748397, EBI-751290;
Q96JS3:PGBD1; NbExp=6; IntAct=EBI-748397, EBI-10290053;
Q13526:PIN1; NbExp=5; IntAct=EBI-748397, EBI-714158;
Q549H9:PKIG; NbExp=3; IntAct=EBI-748397, EBI-10243311;
O15305:PMM2; NbExp=4; IntAct=EBI-748397, EBI-10182608;
Q96T60:PNKP; NbExp=4; IntAct=EBI-748397, EBI-1045072;
A1L4L9:POM121C; NbExp=3; IntAct=EBI-748397, EBI-10172978;
P62140:PPP1CB; NbExp=4; IntAct=EBI-748397, EBI-352350;
O43741:PRKAB2; NbExp=3; IntAct=EBI-748397, EBI-1053424;
A6NJB7:PRR19; NbExp=3; IntAct=EBI-748397, EBI-10174045;
P40306:PSMB10; NbExp=3; IntAct=EBI-748397, EBI-603329;
P62191:PSMC1; NbExp=3; IntAct=EBI-748397, EBI-357598;
Q53XL8:PSMC1; NbExp=3; IntAct=EBI-748397, EBI-10242995;
O00487:PSMD14; NbExp=3; IntAct=EBI-748397, EBI-722193;
O00233:PSMD9; NbExp=4; IntAct=EBI-748397, EBI-750973;
P43115-12:PTGER3; NbExp=3; IntAct=EBI-748397, EBI-10234038;
P10826-2:RARB; NbExp=3; IntAct=EBI-748397, EBI-8583223;
Q96PM5:RCHY1; NbExp=3; IntAct=EBI-748397, EBI-947779;
Q6P9E2:RECK; NbExp=5; IntAct=EBI-748397, EBI-10253121;
Q52LD8:RFTN2; NbExp=4; IntAct=EBI-748397, EBI-12278276;
Q9H4E5:RHOJ; NbExp=3; IntAct=EBI-748397, EBI-6285694;
Q9H871:RMND5A; NbExp=3; IntAct=EBI-748397, EBI-2797992;
P61313:RPL15; NbExp=5; IntAct=EBI-748397, EBI-443462;
P62829:RPL23; NbExp=4; IntAct=EBI-748397, EBI-353303;
Q06455-4:RUNX1T1; NbExp=3; IntAct=EBI-748397, EBI-10224192;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-748397, EBI-10313866;
Q9BWG6:SCNM1; NbExp=3; IntAct=EBI-748397, EBI-748391;
O00560:SDCBP; NbExp=4; IntAct=EBI-748397, EBI-727004;
Q01105:SET; NbExp=3; IntAct=EBI-748397, EBI-1053182;
Q9H788:SH2D4A; NbExp=4; IntAct=EBI-748397, EBI-747035;
O00241-2:SIRPB1; NbExp=3; IntAct=EBI-748397, EBI-10179231;
Q6P1K1:SLC48A1; NbExp=3; IntAct=EBI-748397, EBI-1222191;
P84022:SMAD3; NbExp=6; IntAct=EBI-748397, EBI-347161;
Q969G3:SMARCE1; NbExp=7; IntAct=EBI-748397, EBI-455078;
Q8NB12:SMYD1; NbExp=4; IntAct=EBI-748397, EBI-8463848;
P10451:SPP1; NbExp=3; IntAct=EBI-748397, EBI-723648;
O43609:SPRY1; NbExp=5; IntAct=EBI-748397, EBI-3866665;
O43597:SPRY2; NbExp=3; IntAct=EBI-748397, EBI-742487;
Q99909:SSX3; NbExp=3; IntAct=EBI-748397, EBI-10295431;
O75716:STK16; NbExp=3; IntAct=EBI-748397, EBI-749295;
O75558:STX11; NbExp=3; IntAct=EBI-748397, EBI-714135;
O14662:STX16; NbExp=3; IntAct=EBI-748397, EBI-2853548;
P61764:STXBP1; NbExp=3; IntAct=EBI-748397, EBI-960169;
Q9BSW7:SYT17; NbExp=7; IntAct=EBI-748397, EBI-745392;
Q53T94:TAF1B; NbExp=4; IntAct=EBI-748397, EBI-1560239;
Q5QJ74:TBCEL; NbExp=3; IntAct=EBI-748397, EBI-10244795;
Q15560:TCEA2; NbExp=5; IntAct=EBI-748397, EBI-710310;
A0A024R6G0:TCL6; NbExp=3; IntAct=EBI-748397, EBI-10173366;
Q8N7M0:TCTEX1D1; NbExp=3; IntAct=EBI-748397, EBI-10267606;
P01137:TGFB1; NbExp=3; IntAct=EBI-748397, EBI-779636;
Q86XR7:TICAM2; NbExp=3; IntAct=EBI-748397, EBI-525927;
Q9NV29:TMEM100; NbExp=3; IntAct=EBI-748397, EBI-8644968;
Q12888:TP53BP1; NbExp=3; IntAct=EBI-748397, EBI-396540;
Q9Y4K3:TRAF6; NbExp=3; IntAct=EBI-748397, EBI-359276;
Q8WV44:TRIM41; NbExp=7; IntAct=EBI-748397, EBI-725997;
Q8IWZ5:TRIM42; NbExp=5; IntAct=EBI-748397, EBI-5235829;
Q96NG3:TTC25; NbExp=3; IntAct=EBI-748397, EBI-1046387;
Q5VTQ0-4:TTC39B; NbExp=3; IntAct=EBI-748397, EBI-10247626;
Q8N5M4:TTC9C; NbExp=5; IntAct=EBI-748397, EBI-2851213;
P40222:TXLNA; NbExp=3; IntAct=EBI-748397, EBI-359793;
P11441:UBL4A; NbExp=3; IntAct=EBI-748397, EBI-356983;
Q8N7F7:UBL4B; NbExp=3; IntAct=EBI-748397, EBI-10267507;
Q9H3U1:UNC45A; NbExp=5; IntAct=EBI-748397, EBI-1048763;
Q9NZ43:USE1; NbExp=3; IntAct=EBI-748397, EBI-742842;
P11473:VDR; NbExp=3; IntAct=EBI-748397, EBI-286357;
Q8NEX5:WFDC9; NbExp=3; IntAct=EBI-748397, EBI-10270812;
O43543:XRCC2; NbExp=3; IntAct=EBI-748397, EBI-3918457;
O75132:ZBED4; NbExp=3; IntAct=EBI-748397, EBI-2860059;
Q96NC0:ZMAT2; NbExp=3; IntAct=EBI-748397, EBI-2682299;
Q15973:ZNF124; NbExp=5; IntAct=EBI-748397, EBI-2555767;
Q86UD4:ZNF329; NbExp=3; IntAct=EBI-748397, EBI-7233259;
Q494X3:ZNF404; NbExp=3; IntAct=EBI-748397, EBI-10241626;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-748397, EBI-740727;
Q6P088:ZNF483; NbExp=3; IntAct=EBI-748397, EBI-10196963;
Q8TBZ8:ZNF564; NbExp=3; IntAct=EBI-748397, EBI-10273713;
Q7Z3I7:ZNF572; NbExp=3; IntAct=EBI-748397, EBI-10172590;
Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-748397, EBI-6427977;
Q8IW36:ZNF695; NbExp=3; IntAct=EBI-748397, EBI-10261951;
Q6ZMS7:ZNF783; NbExp=4; IntAct=EBI-748397, EBI-10254978;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19266028,
ECO:0000269|PubMed:22206000}. Nucleus speckle
{ECO:0000255|PROSITE-ProRule:PRU00108,
ECO:0000269|PubMed:19266028}.
-!- TISSUE SPECIFICITY: Embryo and placenta.
-!- DOMAIN: The polyhistidine repeat may act as a targeting signal to
nuclear speckles. {ECO:0000269|PubMed:19266028}.
-!- POLYMORPHISM: The poly-His region of MEOX2 is polymorphic and the
number of His varies in the population.
{ECO:0000269|PubMed:19760604}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X82629; CAA57949.1; -; mRNA.
EMBL; L36328; AAA58497.1; -; mRNA.
EMBL; AK313386; BAG36184.1; -; mRNA.
EMBL; AC005550; AAC33152.1; -; Genomic_DNA.
EMBL; AC004452; AAC06184.1; -; Genomic_DNA.
EMBL; CH236948; EAL24289.1; -; Genomic_DNA.
EMBL; BC017021; AAH17021.1; -; mRNA.
CCDS; CCDS34605.1; -.
PIR; A55641; A55641.
PIR; A56837; A56837.
RefSeq; NP_005915.2; NM_005924.4.
UniGene; Hs.170355; -.
ProteinModelPortal; P50222; -.
SMR; P50222; -.
BioGrid; 110386; 212.
IntAct; P50222; 655.
MINT; MINT-202865; -.
STRING; 9606.ENSP00000262041; -.
iPTMnet; P50222; -.
PhosphoSitePlus; P50222; -.
BioMuta; MEOX2; -.
DMDM; 93141286; -.
PaxDb; P50222; -.
PeptideAtlas; P50222; -.
PRIDE; P50222; -.
DNASU; 4223; -.
Ensembl; ENST00000262041; ENSP00000262041; ENSG00000106511.
GeneID; 4223; -.
KEGG; hsa:4223; -.
UCSC; uc003stc.4; human.
CTD; 4223; -.
DisGeNET; 4223; -.
EuPathDB; HostDB:ENSG00000106511.5; -.
GeneCards; MEOX2; -.
H-InvDB; HIX0006493; -.
HGNC; HGNC:7014; MEOX2.
HPA; HPA053793; -.
MIM; 600535; gene.
neXtProt; NX_P50222; -.
OpenTargets; ENSG00000106511; -.
PharmGKB; PA30748; -.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
GeneTree; ENSGT00760000118940; -.
HOGENOM; HOG000230987; -.
HOVERGEN; HBG052456; -.
InParanoid; P50222; -.
KO; K09322; -.
OMA; SWHIPQM; -.
OrthoDB; EOG091G0PFO; -.
PhylomeDB; P50222; -.
TreeFam; TF351603; -.
SIGNOR; P50222; -.
ChiTaRS; MEOX2; human.
GeneWiki; MEOX2; -.
GenomeRNAi; 4223; -.
PRO; PR:P50222; -.
Proteomes; UP000005640; Chromosome 7.
Bgee; ENSG00000106511; -.
CleanEx; HS_MEOX2; -.
Genevisible; P50222; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:NTNU_SB.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:NTNU_SB.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0008015; P:blood circulation; TAS:ProtInc.
GO; GO:0060173; P:limb development; IEA:Ensembl.
GO; GO:0007275; P:multicellular organism development; TAS:ProtInc.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IGI:BHF-UCL.
GO; GO:0070997; P:neuron death; IMP:UniProtKB.
GO; GO:0060021; P:palate development; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO; GO:0061053; P:somite development; IBA:GO_Central.
GO; GO:0001757; P:somite specification; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Activator; Complete proteome; Developmental protein; DNA-binding;
Homeobox; Nucleus; Polymorphism; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 304 Homeobox protein MOX-2.
/FTId=PRO_0000049197.
DNA_BIND 187 246 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 42 47 Poly-Ser.
COMPBIAS 68 80 Poly-His.
COMPBIAS 81 86 Poly-Gln.
VARIANT 79 80 Missing. {ECO:0000269|PubMed:7713505}.
/FTId=VAR_026040.
VARIANT 80 80 Missing. {ECO:0000269|PubMed:12690205,
ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:7607679}.
/FTId=VAR_026041.
VARIANT 287 287 I -> L (in dbSNP:rs2237493).
/FTId=VAR_049585.
MUTAGEN 236 236 Q->E: Abolishes DNA-binding. Does not
affect ability to activate expression of
CDKN2A. {ECO:0000269|PubMed:22206000}.
CONFLICT 58 58 G -> D (in Ref. 2; AAA58497).
{ECO:0000305}.
SEQUENCE 304 AA; 33594 MW; 0C008479D6995389 CRC64;
MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF
ASQHHRGHHH HHHHHHHHHH QQQQHQALQT NWHLPQMSSP PSAARHSLCL QPDSGGPPEL
GSSPPVLCSN SSSLGSSTPT GAACAPGDYG RQALSPAEAE KRSGGKRKSD SSDSQEGNYK
SEVNSKPRKE RTAFTKEQIR ELEAEFAHHN YLTRLRRYEI AVNLDLTERQ VKVWFQNRRM
KWKRVKGGQQ GAAAREKELV NVKKGTLLPS ELSGIGAATL QQTGDSIANE DSHDSDHSSE
HAHL


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