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Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein)

 MSX1_HUMAN              Reviewed;         303 AA.
P28360; A0SZU5; A8K3M1; Q96NY4;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
13-NOV-2013, sequence version 3.
31-JAN-2018, entry version 193.
RecName: Full=Homeobox protein MSX-1;
AltName: Full=Homeobox protein Hox-7;
AltName: Full=Msh homeobox 1-like protein;
Name=MSX1; Synonyms=HOX7;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Lymphocyte;
PubMed=1685479; DOI=10.1016/0888-7543(91)90074-O;
Hewitt J.E., Clarke L.E., Iven A., Williamson R.;
"Structure and sequence of the human homeobox gene HOX7.";
Genomics 11:670-678(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ectomesenchyme;
PubMed=1284527; DOI=10.1093/hmg/1.6.407;
Padanilam B.J., Stadler S.H., Mills K.A., McLeod L.B., Solursh M.,
Lee B.M., Ramirez F., Buetow K.H., Murray J.C.;
"Characterization of the human HOX 7 cDNA and identification of
polymorphic markers.";
Hum. Mol. Genet. 1:407-410(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND VARIANTS OFC5 VAL-84;
ASP-97; GLY-120; GLU-122 AND SER-157.
PubMed=12807959; DOI=10.1136/jmg.40.6.399;
Jezewski P.A., Vieira A.R., Nishimura C., Ludwig B., Johnson M.,
O'Brien S.E., Daack-Hirsch S., Schultz R.E., Weber A., Nepomucena B.,
Romitti P.A., Christensen K., Orioli I.M., Castilla E.E., Machida J.,
Natsume N., Murray J.C.;
"Complete sequencing shows a role for MSX1 in non-syndromic cleft lip
and palate.";
J. Med. Genet. 40:399-407(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-157.
TISSUE=Embryo;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Neuroblastoma, and Pancreatic carcinoma;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-156.
Prasad S., Shama Rao K., Mukhyopadhyay A.;
"Single nucleotide polymorphism analysis of the MSX1 gene within
Indian population for cleft lip and palate.";
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 191-251, AND INVOLVEMENT IN
WOLF-HIRSCHHORN SYNDROME.
PubMed=1969845; DOI=10.1007/BF00195823;
Ivens A., Flavin N., Williamson R., Dixon M., Bates G., Buckingham M.,
Robert B.;
"The human homeobox gene HOX7 maps to chromosome 4p16.1 and may be
implicated in Wolf-Hirschhorn syndrome.";
Hum. Genet. 84:473-476(1990).
[9]
FUNCTION, TISSUE SPECIFICITY, AND INVOLVEMENT IN ECTD3.
PubMed=11369996; DOI=10.1086/321271;
Jumlongras D., Bei M., Stimson J.M., Wang W.-F., DePalma S.R.,
Seidman C.E., Felbor U., Maas R., Seidman J.G., Olsen B.R.;
"A nonsense mutation in MSX1 causes Witkop syndrome.";
Am. J. Hum. Genet. 69:67-74(2001).
[10]
VARIANT STHAG1 PRO-202.
PubMed=8696335; DOI=10.1038/ng0896-417;
Vastardis H., Karimbux N., Guthua S.W., Seidman J.G., Seidman C.E.;
"A human MSX1 homeodomain missense mutation causes selective tooth
agenesis.";
Nat. Genet. 13:417-421(1996).
[11]
VARIANT STHAG1 LYS-67.
PubMed=12097313; DOI=10.1177/154405910208100410;
Lidral A.C., Reising B.C.;
"The role of MSX1 in human tooth agenesis.";
J. Dent. Res. 81:274-278(2002).
-!- FUNCTION: Acts as a transcriptional repressor. May play a role in
limb-pattern formation. Acts in cranofacial development and
specifically in odontogenesis. Expression in the developing nail
bed mesenchyme is important for nail plate thickness and
integrity. {ECO:0000269|PubMed:11369996,
ECO:0000269|PubMed:12807959}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed in the developing nail bed
mesenchyme. {ECO:0000269|PubMed:11369996}.
-!- PTM: Sumoylated by PIAS1, desumoylated by SENP1. {ECO:0000250}.
-!- DISEASE: Tooth agenesis, selective, 1 (STHAG1) [MIM:106600]: A
form of selective tooth agenesis, a common anomaly characterized
by the congenital absence of one or more teeth. Selective tooth
agenesis without associated systemic disorders has sometimes been
divided into 2 types: oligodontia, defined as agenesis of 6 or
more permanent teeth, and hypodontia, defined as agenesis of less
than 6 teeth. The number in both cases does not include absence of
third molars (wisdom teeth). STHAG1 can be associated with
orofacial cleft in some patients. {ECO:0000269|PubMed:12097313,
ECO:0000269|PubMed:8696335}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- DISEASE: Note=MSX1 is deleted in some patients with Wolf-
Hirschhorn syndrome (WHS). WHS results from sub-telomeric
deletions in the short arm of chromosome 4.
{ECO:0000305|PubMed:1969845}.
-!- DISEASE: Ectodermal dysplasia 3, Witkop type (ECTD3) [MIM:189500]:
A form of ectodermal dysplasia, a heterogeneous group of disorders
due to abnormal development of two or more ectodermal structures
such as hair, teeth, nails and sweat glands, with or without any
additional clinical sign. Each combination of clinical features
represents a different type of ectodermal dysplasia. ECTD3 is
characterized by abnormalities largely limited largely to teeth
(some of which are missing) and nails (which are poorly formed
early in life, especially toenails). This condition is
distinguished from anhidrotic ectodermal dysplasia by autosomal
dominant inheritance and little involvement of hair and sweat
glands. The teeth are not as severely affected.
{ECO:0000269|PubMed:11369996}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- DISEASE: Non-syndromic orofacial cleft 5 (OFC5) [MIM:608874]: A
birth defect consisting of cleft lips with or without cleft
palate. Cleft lips are associated with cleft palate in two-third
of cases. A cleft lip can occur on one or both sides and range in
severity from a simple notch in the upper lip to a complete
opening in the lip extending into the floor of the nostril and
involving the upper gum. {ECO:0000269|PubMed:12807959}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA52683.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAA58665.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAH67353.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAL17870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=ABK81117.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=BAF83325.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
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EMBL; M76732; AAA58665.1; ALT_INIT; Genomic_DNA.
EMBL; M76731; AAA58665.1; JOINED; Genomic_DNA.
EMBL; M97676; AAA52683.1; ALT_INIT; mRNA.
EMBL; AF426432; AAL17870.1; ALT_INIT; Genomic_DNA.
EMBL; AK290636; BAF83325.1; ALT_INIT; mRNA.
EMBL; AC092437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC021285; AAH21285.4; -; mRNA.
EMBL; BC067353; AAH67353.1; ALT_INIT; mRNA.
EMBL; EF065625; ABK81117.1; ALT_INIT; Genomic_DNA.
CCDS; CCDS3378.2; -.
PIR; A40560; A40560.
PIR; I54320; I54320.
RefSeq; NP_002439.2; NM_002448.3.
UniGene; Hs.424414; -.
ProteinModelPortal; P28360; -.
SMR; P28360; -.
BioGrid; 110593; 14.
CORUM; P28360; -.
IntAct; P28360; 4.
MINT; MINT-6611751; -.
STRING; 9606.ENSP00000372170; -.
iPTMnet; P28360; -.
PhosphoSitePlus; P28360; -.
BioMuta; MSX1; -.
DMDM; 557952603; -.
MaxQB; P28360; -.
PaxDb; P28360; -.
PeptideAtlas; P28360; -.
PRIDE; P28360; -.
Ensembl; ENST00000382723; ENSP00000372170; ENSG00000163132.
GeneID; 4487; -.
KEGG; hsa:4487; -.
UCSC; uc003gif.4; human.
CTD; 4487; -.
DisGeNET; 4487; -.
EuPathDB; HostDB:ENSG00000163132.6; -.
GeneCards; MSX1; -.
HGNC; HGNC:7391; MSX1.
HPA; CAB026198; -.
HPA; HPA063895; -.
HPA; HPA073604; -.
MalaCards; MSX1; -.
MIM; 106600; phenotype.
MIM; 142983; gene.
MIM; 189500; phenotype.
MIM; 608874; phenotype.
neXtProt; NX_P28360; -.
OpenTargets; ENSG00000163132; -.
Orphanet; 199306; Cleft lip/palate.
Orphanet; 2227; Hypodontia.
Orphanet; 2228; Hypodontia - dysplasia of nails.
Orphanet; 99798; Oligodontia.
PharmGKB; PA31196; -.
eggNOG; KOG0492; Eukaryota.
eggNOG; ENOG410YT2J; LUCA.
GeneTree; ENSGT00900000140771; -.
HOGENOM; HOG000231922; -.
HOVERGEN; HBG005205; -.
InParanoid; P28360; -.
KO; K09341; -.
OMA; CMAPSIA; -.
OrthoDB; EOG091G0P1V; -.
PhylomeDB; P28360; -.
TreeFam; TF350699; -.
SignaLink; P28360; -.
SIGNOR; P28360; -.
ChiTaRS; MSX1; human.
GeneWiki; MSX1; -.
GenomeRNAi; 4487; -.
PRO; PR:P28360; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000163132; -.
CleanEx; HS_MSX1; -.
Genevisible; P28360; HS.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
GO; GO:0035326; F:enhancer binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IPI:BHF-UCL.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000982; F:transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0090427; P:activation of meiosis; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0060349; P:bone morphogenesis; IEA:Ensembl.
GO; GO:0060536; P:cartilage morphogenesis; IEA:Ensembl.
GO; GO:0000902; P:cell morphogenesis; IDA:BHF-UCL.
GO; GO:0071316; P:cellular response to nicotine; IEA:Ensembl.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0035880; P:embryonic nail plate morphogenesis; IMP:BHF-UCL.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0060325; P:face morphogenesis; IMP:BHF-UCL.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0061180; P:mammary gland epithelium development; IEA:Ensembl.
GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:0030901; P:midbrain development; IEA:Ensembl.
GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO; GO:0007517; P:muscle organ development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:0051154; P:negative regulation of striated muscle cell differentiation; IEA:Ensembl.
GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:BHF-UCL.
GO; GO:0060021; P:palate development; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IC:BHF-UCL.
GO; GO:1902255; P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IDA:BHF-UCL.
GO; GO:2001055; P:positive regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
GO; GO:0034504; P:protein localization to nucleus; IDA:BHF-UCL.
GO; GO:0050821; P:protein stabilization; IDA:BHF-UCL.
GO; GO:0042481; P:regulation of odontogenesis; IEA:Ensembl.
GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Ensembl.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Disease mutation;
DNA-binding; Ectodermal dysplasia; Homeobox; Isopeptide bond; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 303 Homeobox protein MSX-1.
/FTId=PRO_0000049086.
DNA_BIND 172 231 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 35 42 Poly-Ala.
COMPBIAS 261 269 Poly-Ala.
CROSSLNK 15 15 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
CROSSLNK 133 133 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
VARIANT 67 67 M -> K (in STHAG1; dbSNP:rs121913130).
{ECO:0000269|PubMed:12097313}.
/FTId=VAR_015712.
VARIANT 84 84 E -> V (in OFC5; cleft palate only;
dbSNP:rs28928890).
{ECO:0000269|PubMed:12807959}.
/FTId=VAR_018391.
VARIANT 97 97 G -> D (in OFC5; cleft palate only).
{ECO:0000269|PubMed:12807959}.
/FTId=VAR_018392.
VARIANT 120 120 V -> G (in OFC5; cleft palate only;
dbSNP:rs759548721).
{ECO:0000269|PubMed:12807959}.
/FTId=VAR_018393.
VARIANT 122 122 G -> E (in OFC5; bilateral cleft palate;
dbSNP:rs28933081).
{ECO:0000269|PubMed:12807959}.
/FTId=VAR_018394.
VARIANT 157 157 R -> S (in OFC5; unilateral cleft palate;
dbSNP:rs150284621).
{ECO:0000269|PubMed:12807959,
ECO:0000269|PubMed:14702039}.
/FTId=VAR_018395.
VARIANT 202 202 R -> P (in STHAG1; dbSNP:rs121913129).
{ECO:0000269|PubMed:8696335}.
/FTId=VAR_003754.
CONFLICT 28 28 G -> D (in Ref. 4; BAF83325).
{ECO:0000305}.
CONFLICT 45 45 A -> T (in Ref. 2; AAA58665).
{ECO:0000305}.
CONFLICT 97 99 GVP -> ASR (in Ref. 2; AAA58665).
{ECO:0000305}.
CONFLICT 146 146 M -> T (in Ref. 4; BAF83325).
{ECO:0000305}.
CONFLICT 222 222 N -> S (in Ref. 4; BAF83325).
{ECO:0000305}.
SEQUENCE 303 AA; 31496 MW; 1B5F01B35920E64F CRC64;
MAPAADMTSL PLGVKVEDSA FGKPAGGGAG QAPSAAAATA AAMGADEEGA KPKVSPSLLP
FSVEALMADH RKPGAKESAL APSEGVQAAG GSAQPLGVPP GSLGAPDAPS SPRPLGHFSV
GGLLKLPEDA LVKAESPEKP ERTPWMQSPR FSPPPARRLS PPACTLRKHK TNRKPRTPFT
TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM
AAKPMLPPAA FGLSFPLGGP AAVAAAAGAS LYGASGPFQR AALPVAPVGL YTAHVGYSMY
HLT


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EIAAB42541 Homeobox protein Hox-11L1,Homo sapiens,HOX11L1,Human,NCX,Neural crest homeobox protein,T-cell leukemia homeobox protein 2,TLX2
18-003-42354 Short stature homeobox protein 2 - Paired-related homeobox protein SHOT; Homeobox protein Og12X Polyclonal 0.05 mg Aff Pur
18-003-42353 Short stature homeobox protein 2 - Paired-related homeobox protein SHOT; Homeobox protein Og12X Polyclonal 0.05 mg Aff Pur
18-003-42353 Short stature homeobox protein 2 - Paired-related homeobox protein SHOT; Homeobox protein Og12X Polyclonal 0.1 mg Protein A
18-003-42354 Short stature homeobox protein 2 - Paired-related homeobox protein SHOT; Homeobox protein Og12X Polyclonal 0.1 mg Protein A
18-003-43167 Diencephalon_mesencephalon homeobox protein 1 - Diencephalon_mesencephalon-expressed brain homeobox gene 1 protein; Paired-like homeobox protein DMBX1; Paired-type homeobox Atx; Orthodenticle homolog 0.05 mg Aff Pur
18-003-43511 T-cell leukemia homeobox protein 2 - Homeobox protein Hox-11L1; Neural crest homeobox protein Polyclonal 0.1 mg Protein A
18-003-42195 Homeobox protein SIX6 - Sine oculis homeobox homolog 6; Optic homeobox 2; Homeodomain protein OPTX2 Polyclonal 0.05 mg Aff Pur
25-316 HOXB8 belongs to the Antp homeobox family. It is a nuclear protein with a homeobox DNA-binding domain. This gene is included in a cluster of homeobox B genes located on chromosome 17. The protein func 0.05 mg
EIAAB27447 Homeobox protein NOBOX,Homeodomain-containing protein OG-2,Mouse,Mus musculus,Newborn ovary homeobox protein,Nobox,Og2x,Oocyte-specific homeobox protein
EIAAB25563 Homeobox protein Hox-7,Homeobox protein MSX-1,Homo sapiens,HOX7,Human,Msh homeobox 1-like protein,MSX1
EIAAB42540 Homeobox protein Hox-11,Homeobox TLX-1,Hox11,Mouse,Mus musculus,T-cell leukemia homeobox protein 1,Tlx1,Tlx-1
EIAAB30960 Aristaless homeobox protein homolog,ARIX,ARIX1 homeodomain protein,Homo sapiens,Human,Paired mesoderm homeobox protein 2A,Paired-like homeobox 2A,PHOX2A,PMX2A
EIAAB30959 Aristaless homeobox protein homolog,Arix,ARIX1 homeodomain protein,Paired mesoderm homeobox protein 2A,Paired-like homeobox 2A,Phox2a,Pmx2a,Rat,Rattus norvegicus
EIAAB24840 hMix,Homeobox protein MIXL1,Homeodomain protein MIX,Homo sapiens,Human,Mix.1 homeobox-like protein,MIX1 homeobox-like protein 1,MIXL,MIXL1
18-003-44021 ES cells cDNA. RIKEN full-length enriched library. clone C330003B14 product hypothetical Homeobox domain containing protein. ful - Cytoplasmic polyadenylated homeobox; Homeobox protein ESO1 Polyclonal 0.1 mg Protein A
EIAAB32587 Homeobox protein PHOX1,Homo sapiens,Human,Paired mesoderm homeobox protein 1,Paired-related homeobox protein 1,PMX1,PRRX1,PRX-1
EIAAB27320 Bagpipe homeobox protein homolog 1,BAPX1,Homeobox protein NK-3 homolog B,Homeobox protein Nkx-3.2,Homo sapiens,Human,NKX3-2,NKX3B


 

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