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Homeobox protein MSX-2 (Homeobox protein Hox-8)

 MSX2_CANLF              Reviewed;         267 AA.
Q9GK08;
16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
28-MAR-2018, entry version 120.
RecName: Full=Homeobox protein MSX-2;
AltName: Full=Homeobox protein Hox-8;
Name=MSX2;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Haworth K.E., Edwards Y.H.;
"The homeodomain Msx2 protein sequence is highly conserved between
between domestic dog breeds of varying face and skull types.";
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11419342; DOI=10.1046/j.1365-2052.2001.00702.x;
Haworth K., Breen M., Binns M., Hopkinson D.A., Edwards Y.H.;
"The canine homeobox gene MSX2: sequence, chromosome assignment and
genetic analysis in dogs of different breeds.";
Anim. Genet. 32:32-36(2001).
-!- FUNCTION: Acts as a transcriptional regulator in bone development.
Represses the ALPL promoter activity and antogonizes the
stimulatory effect of DLX5 on ALPL expression during osteoblast
differentiation. Probable morphogenetic role. May play a role in
limb-pattern formation. In osteoblasts, suppresses transcription
driven by the osteocalcin FGF response element (OCFRE). Binds to
the homeodomain-response element of the ALPL promoter (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00108}.
-!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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EMBL; AJ277753; CAC19897.1; -; mRNA.
EMBL; AJ303104; CAC37368.1; -; Genomic_DNA.
EMBL; AJ303105; CAC37368.1; JOINED; Genomic_DNA.
RefSeq; NP_001003098.1; NM_001003098.2.
UniGene; Cfa.3529; -.
ProteinModelPortal; Q9GK08; -.
SMR; Q9GK08; -.
STRING; 9615.ENSCAFP00000024602; -.
PaxDb; Q9GK08; -.
Ensembl; ENSCAFT00000026491; ENSCAFP00000024602; ENSCAFG00000016731.
Ensembl; ENSCAFT00000046226; ENSCAFP00000041488; ENSCAFG00000016731.
GeneID; 403663; -.
KEGG; cfa:403663; -.
CTD; 4488; -.
VGNC; VGNC:43455; MSX2.
eggNOG; KOG0492; Eukaryota.
eggNOG; ENOG410YT2J; LUCA.
GeneTree; ENSGT00910000143987; -.
HOGENOM; HOG000231922; -.
HOVERGEN; HBG005205; -.
InParanoid; Q9GK08; -.
KO; K09341; -.
OMA; PLGYSMY; -.
OrthoDB; EOG091G0P1V; -.
TreeFam; TF350699; -.
Proteomes; UP000002254; Chromosome 4.
Bgee; ENSCAFG00000016731; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003712; F:transcription cofactor activity; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0090427; P:activation of meiosis; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Ensembl.
GO; GO:0060346; P:bone trabecula formation; IEA:Ensembl.
GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Ensembl.
GO; GO:0071392; P:cellular response to estradiol stimulus; IEA:Ensembl.
GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0035880; P:embryonic nail plate morphogenesis; IEA:Ensembl.
GO; GO:0070166; P:enamel mineralization; IEA:Ensembl.
GO; GO:0003416; P:endochondral bone growth; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0060364; P:frontal suture morphogenesis; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0045617; P:negative regulation of keratinocyte differentiation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:2001055; P:positive regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0051795; P:positive regulation of timing of catagen; IEA:Ensembl.
GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Ensembl.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0035313; P:wound healing, spreading of epidermal cells; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Osteogenesis; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 267 Homeobox protein MSX-2.
/FTId=PRO_0000049098.
DNA_BIND 142 201 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
SEQUENCE 267 AA; 28609 MW; F0550CCBE9F10CE0 CRC64;
MASPSKGSDL FSSDEEGPAA LAGPGPGPGG AEGAAEERRV KVSSLPFSVE ALMSDKKPPK
GASPRPADSA SAGAALRPLL LPGHGAREAP SPGPPGKPFE AASVKSESAE DGAAWMQEPG
RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN
LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASIYGASY
PFHRPVLPIP PVGLYATPVG YGMYHLS


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