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Homeobox protein MSX-2 (Homeobox protein Hox-8-1)

 MSX2_MOUSE              Reviewed;         267 AA.
Q03358; Q63856;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 2.
31-JAN-2018, entry version 159.
RecName: Full=Homeobox protein MSX-2;
AltName: Full=Homeobox protein Hox-8-1;
Name=Msx2; Synonyms=Hox-8.1, Msx-2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
PubMed=1682128;
Monaghan A.P., Davidson D.R., Sime C., Graham E., Baldock R.,
Bhattacharya S.S., Hill R.E.;
"The Msh-like homeobox genes define domains in the developing
vertebrate eye.";
Development 112:1053-1061(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8098007; DOI=10.1006/geno.1993.1149;
Bell J.R., Noveen A., Liu Y.H., Ma L., Dobias S., Kundu R., Luo W.,
Xia Y.;
"Genomic structure, chromosomal location, and evolution of the mouse
Hox 8 gene.";
Genomics 16:123-131(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 142-202.
PubMed=1673109; DOI=10.1016/0378-1119(91)90182-B;
Holland P.W.H.;
"Cloning and evolutionary analysis of msh-like homeobox genes from
mouse, zebrafish and ascidian.";
Gene 98:253-257(1991).
[4]
FUNCTION.
PubMed=1677742; DOI=10.1038/352429a0;
Davidson D.R., Crawley A., Hill R.E., Tickle C.;
"Position-dependent expression of two related homeobox genes in
developing vertebrate limbs.";
Nature 352:429-431(1991).
[5]
INTERACTION WITH MINT.
PubMed=10451362; DOI=10.1021/bi990967j;
Newberry E.P., Latifi T., Towler D.A.;
"The RRM domain of MINT, a novel msx2 binding protein, recognizes and
regulates the rat osteocalcin promoter.";
Biochemistry 38:10678-10690(1999).
[6]
FUNCTION, INDUCTION, AND DNA-BINDING.
PubMed=15383550; DOI=10.1074/jbc.M404145200;
Kim Y.J., Lee M.H., Wozney J.M., Cho J.Y., Ryoo H.M.;
"Bone morphogenetic protein-2-induced alkaline phosphatase expression
is stimulated by Dlx5 and repressed by Msx2.";
J. Biol. Chem. 279:50773-50780(2004).
-!- FUNCTION: Acts as a transcriptional regulator in bone development.
Represses the ALPL promoter activity and antogonizes the
stimulatory effect of DLX5 on ALPL expression during osteoblast
differentiation. Probable morphogenetic role. May play a role in
limb-pattern formation. In osteoblasts, suppresses transcription
driven by the osteocalcin FGF response element (OCFRE). Binds to
the homeodomain-response element of the ALPL promoter.
{ECO:0000269|PubMed:15383550, ECO:0000269|PubMed:1677742}.
-!- SUBUNIT: Interacts with MINT. Interacts with XRCC6 (Ku70) and
XRCC5 (Ku80) (By similarity). {ECO:0000250}.
-!- INTERACTION:
Q9QYH6:Maged1; NbExp=5; IntAct=EBI-1801354, EBI-1801274;
P25233:Ndn; NbExp=3; IntAct=EBI-1801354, EBI-1801080;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed in mesenchymal tissue in the
developing spinal cord and limbs.
-!- INDUCTION: Up-regulated by BMP2. {ECO:0000269|PubMed:15383550}.
-!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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EMBL; L11739; AAA03477.1; -; Unassigned_DNA.
EMBL; L11738; AAA03477.1; JOINED; Unassigned_DNA.
EMBL; S60460; AAC60657.2; -; Genomic_DNA.
EMBL; S60698; AAC60657.2; JOINED; Genomic_DNA.
EMBL; X59252; CAA41945.1; -; mRNA.
EMBL; M38576; AAA37824.1; -; Genomic_DNA.
CCDS; CCDS26522.1; -.
PIR; A46122; A46122.
PIR; PS0410; PS0410.
PIR; S18814; S18814.
RefSeq; NP_038629.2; NM_013601.2.
UniGene; Mm.1763; -.
ProteinModelPortal; Q03358; -.
SMR; Q03358; -.
BioGrid; 201537; 4.
IntAct; Q03358; 3.
STRING; 10090.ENSMUSP00000021922; -.
iPTMnet; Q03358; -.
PhosphoSitePlus; Q03358; -.
PaxDb; Q03358; -.
PRIDE; Q03358; -.
Ensembl; ENSMUST00000021922; ENSMUSP00000021922; ENSMUSG00000021469.
GeneID; 17702; -.
KEGG; mmu:17702; -.
UCSC; uc007qnw.1; mouse.
CTD; 4488; -.
MGI; MGI:97169; Msx2.
eggNOG; KOG0492; Eukaryota.
eggNOG; ENOG410YT2J; LUCA.
GeneTree; ENSGT00900000140771; -.
HOGENOM; HOG000231922; -.
HOVERGEN; HBG005205; -.
InParanoid; Q03358; -.
KO; K09341; -.
OMA; PLGYSMY; -.
OrthoDB; EOG091G0P1V; -.
PhylomeDB; Q03358; -.
TreeFam; TF350699; -.
PRO; PR:Q03358; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000021469; -.
CleanEx; MM_MSX2; -.
ExpressionAtlas; Q03358; baseline and differential.
Genevisible; Q03358; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0016607; C:nuclear speck; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IMP:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
GO; GO:0003712; F:transcription cofactor activity; IDA:BHF-UCL.
GO; GO:0000989; F:transcription factor activity, transcription factor binding; IDA:MGI.
GO; GO:0008134; F:transcription factor binding; IPI:MGI.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO; GO:0001227; F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0090427; P:activation of meiosis; IPI:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
GO; GO:0061312; P:BMP signaling pathway involved in heart development; IGI:MGI.
GO; GO:0060349; P:bone morphogenesis; IGI:MGI.
GO; GO:0060346; P:bone trabecula formation; IMP:MGI.
GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.
GO; GO:0051216; P:cartilage development; IMP:MGI.
GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:MGI.
GO; GO:0071363; P:cellular response to growth factor stimulus; IDA:MGI.
GO; GO:0002063; P:chondrocyte development; IMP:MGI.
GO; GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IGI:MGI.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IGI:MGI.
GO; GO:0030326; P:embryonic limb morphogenesis; IGI:MGI.
GO; GO:0035880; P:embryonic nail plate morphogenesis; IGI:MGI.
GO; GO:0070166; P:enamel mineralization; IMP:MGI.
GO; GO:0003416; P:endochondral bone growth; IMP:MGI.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IGI:MGI.
GO; GO:0060364; P:frontal suture morphogenesis; IMP:MGI.
GO; GO:0061180; P:mammary gland epithelium development; IGI:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IGI:MGI.
GO; GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; IDA:MGI.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IDA:MGI.
GO; GO:0045617; P:negative regulation of keratinocyte differentiation; IMP:MGI.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IDA:BHF-UCL.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0042476; P:odontogenesis; IMP:MGI.
GO; GO:0001503; P:ossification; IMP:MGI.
GO; GO:0002076; P:osteoblast development; IMP:MGI.
GO; GO:0001649; P:osteoblast differentiation; IDA:UniProtKB.
GO; GO:0003151; P:outflow tract morphogenesis; IGI:MGI.
GO; GO:0003148; P:outflow tract septum morphogenesis; IGI:MGI.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IGI:MGI.
GO; GO:2001055; P:positive regulation of mesenchymal cell apoptotic process; IGI:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:MGI.
GO; GO:0051795; P:positive regulation of timing of catagen; IMP:MGI.
GO; GO:0042981; P:regulation of apoptotic process; IDA:MGI.
GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IGI:MGI.
GO; GO:0048863; P:stem cell differentiation; IGI:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0042060; P:wound healing; IMP:MGI.
GO; GO:0035313; P:wound healing, spreading of epidermal cells; IMP:MGI.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Osteogenesis; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 267 Homeobox protein MSX-2.
/FTId=PRO_0000049100.
DNA_BIND 142 201 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
CONFLICT 11 11 F -> FF (in Ref. 1; CAA41945).
{ECO:0000305}.
CONFLICT 89 89 A -> R (in Ref. 2; AAC60657).
{ECO:0000305}.
CONFLICT 263 263 M -> I (in Ref. 1; CAA41945).
{ECO:0000305}.
CONFLICT 266 266 L -> V (in Ref. 1; CAA41945).
{ECO:0000305}.
SEQUENCE 267 AA; 28915 MW; F2F4528D6E9C951E CRC64;
MASPTKGGDL FSSDEEGPAV LAGPGPGPGG AEGSAEERRV KVSSLPFSVE ALMSDKKPPK
ESPAVPPDCA SAGAVLRPLL LPGHGVRDAH SPGPLVKPFE TASVKSENSE DGAPWIQEPG
RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN
LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASIYGASY
PFHRPVLPIP PVGLYATPVG YGMYHLS


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