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Homeobox protein Mix.1

 MIX1_XENLA              Reviewed;         377 AA.
P21711;
01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 2.
27-SEP-2017, entry version 103.
RecName: Full=Homeobox protein Mix.1;
Name=mix-a; Synonyms=mix1;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
INDUCTION.
TISSUE=Gastrula;
PubMed=2567635; DOI=10.1016/0092-8674(89)90335-8;
Rosa F.M.;
"Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed
mostly in the presumptive endodermal cells of Xenopus embryos.";
Cell 57:965-974(1989).
[2]
FUNCTION.
PubMed=12710967; DOI=10.1016/S0012-1606(03)00034-4;
Yamamoto S., Hikasa H., Ono H., Taira M.;
"Molecular link in the sequential induction of the Spemann organizer:
direct activation of the cerberus gene by Xlim-1, Xotx2, Mix.1, and
Siamois, immediately downstream from Nodal and Wnt signaling.";
Dev. Biol. 257:190-204(2003).
-!- FUNCTION: Transcription factor which plays a regulatory role in
the development of the embryo. Involved in the establishment of
dorsal/ventral pattern in the early mesoderm. Activates the head
organizer gene cer1 by acting synergistically with otx2 and
siamois through the 5'-TAATCT-3' element of the cer1 promoter.
Also binds as a complex with lhx1/lim1 and siamois to the 3x 5'-
TAAT-3' element of the cer1 promoter.
{ECO:0000269|PubMed:12710967, ECO:0000269|PubMed:2567635}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed mostly in the presumptive endodermal
cells of Xenopus embryos. {ECO:0000269|PubMed:2567635}.
-!- INDUCTION: By activin and TGF-beta1 (immediate early response
gene). {ECO:0000269|PubMed:2567635}.
-!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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EMBL; M27063; AAA49903.1; -; mRNA.
PIR; A32548; A32548.
RefSeq; NP_001081294.1; NM_001087825.1.
UniGene; Xl.824; -.
ProteinModelPortal; P21711; -.
SMR; P21711; -.
IntAct; P21711; 1.
GeneID; 397759; -.
KEGG; xla:397759; -.
CTD; 397759; -.
Xenbase; XB-GENE-865559; mixl1.
HOVERGEN; HBG006359; -.
GO; GO:0005634; C:nucleus; IC:UniProtKB.
GO; GO:0001103; F:RNA polymerase II repressing transcription factor binding; IPI:BHF-UCL.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
Pfam; PF00046; Homeobox; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Developmental protein; DNA-binding; Homeobox; Nucleus.
CHAIN 1 377 Homeobox protein Mix.1.
/FTId=PRO_0000049193.
DNA_BIND 96 155 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 352 368 Asp/Glu-rich (acidic).
SEQUENCE 377 AA; 42250 MW; 6BA404359B57D221 CRC64;
MDGFSQQLED LYPSCFSPCP SPLGFSEPVI QPFAMNLAPA AQKDFQQHPN RREVTKIPGA
GEQSPVQNVR PKDAINPKEA DPRSPTADAS LVPASQRRKR TFFTQAQLDI LEQFFQTNMY
PDIHHREELA RHIYIPESRI QVWFQNRRAK VRRQGAKATK PILAGHHYSG TSGANRAMFP
SAPAPNSSSH QMTTSRAQVQ PLKESQMNMF HQNQGFLPYP DSSCNVSRQR FLMSQPTPGA
YHLPQASSNV YNQNVKSQNP LWNQQTTNRV YTNMMETVLD LSRRPSQQMP VQPMLMNSFQ
TNKNIKPEVY TTSPQIPVST TSSQVSLFAN QEPCHMSTTQ GGTYGQISPI SDSGVSDTSP
EPSSDWEENV ASVLLNL


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