Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Homeobox protein NOBOX (Homeodomain-containing protein OG-2) (Newborn ovary homeobox protein) (Oocyte-specific homeobox protein)

 NOBOX_MOUSE             Reviewed;         527 AA.
Q8VIH1; P70367;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
27-SEP-2017, entry version 121.
RecName: Full=Homeobox protein NOBOX;
AltName: Full=Homeodomain-containing protein OG-2;
AltName: Full=Newborn ovary homeobox protein;
AltName: Full=Oocyte-specific homeobox protein;
Name=Nobox; Synonyms=Og2x;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=129/SvEv;
PubMed=11804785; DOI=10.1016/S0925-4773(01)00620-7;
Suzumori N., Yan C., Matzuk M.M., Rajkovic A.;
"Nobox is a homeobox-encoding gene preferentially expressed in
primordial and growing oocytes.";
Mech. Dev. 111:137-141(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-326, AND DEVELOPMENTAL STAGE.
PubMed=8855241; DOI=10.1073/pnas.93.20.10691;
Rovescalli A.C., Asoh S., Nirenberg M.W.;
"Cloning and characterization of four murine homeobox genes.";
Proc. Natl. Acad. Sci. U.S.A. 93:10691-10696(1996).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=15326356; DOI=10.1126/science.1099755;
Rajkovic A., Pangas S.A., Ballow D., Suzumori N., Matzuk M.M.;
"NOBOX deficiency disrupts early folliculogenesis and oocyte-specific
gene expression.";
Science 305:1157-1159(2004).
[5]
FUNCTION, DNA-BINDING, AND MUTAGENESIS OF ASN-186.
PubMed=16997917; DOI=10.1074/jbc.M604008200;
Choi Y., Rajkovic A.;
"Characterization of NOBOX DNA binding specificity and its regulation
of Gdf9 and Pou5f1 promoters.";
J. Biol. Chem. 281:35747-35756(2006).
[6]
MUTAGENESIS OF ARG-187 AND ARG-192.
PubMed=17701902; DOI=10.1086/519496;
Qin Y., Choi Y., Zhao H., Simpson J.L., Chen Z.-J., Rajkovic A.;
"NOBOX homeobox mutation causes premature ovarian failure.";
Am. J. Hum. Genet. 81:576-581(2007).
-!- FUNCTION: Transcription factor which plays an essential role in
postnatal follicle development. Binds preferentially to the DNA
sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly
regulates the transcription of POU5F1 and GDF9 during early
folliculogenesis. {ECO:0000269|PubMed:15326356,
ECO:0000269|PubMed:16997917}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Specifically expressed in ovaries and testes.
In ovaries, expressed in oocytes from primordial through antral
follicles but not in granulosa cells, theca cells and corpora
lutea. {ECO:0000269|PubMed:11804785}.
-!- DEVELOPMENTAL STAGE: Expressed from E15.5.
{ECO:0000269|PubMed:8855241}.
-!- DISRUPTION PHENOTYPE: Male mice are fertile and show no obvious
abnormality. Female mice lacking Nobox have normal gross anatomy
and histology, but are infertile with atrophic ovaries that lack
oocytes at 6 weeks of age. {ECO:0000269|PubMed:15326356}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AY061761; AAL29683.1; -; mRNA.
EMBL; BC125280; AAI25281.1; -; mRNA.
EMBL; BC125282; AAI25283.1; -; mRNA.
EMBL; U65067; AAC52828.1; -; Genomic_DNA.
CCDS; CCDS20093.1; -.
RefSeq; NP_570939.1; NM_130869.3.
UniGene; Mm.17715; -.
ProteinModelPortal; Q8VIH1; -.
SMR; Q8VIH1; -.
STRING; 10090.ENSMUSP00000031749; -.
iPTMnet; Q8VIH1; -.
PhosphoSitePlus; Q8VIH1; -.
PaxDb; Q8VIH1; -.
PRIDE; Q8VIH1; -.
Ensembl; ENSMUST00000031749; ENSMUSP00000031749; ENSMUSG00000029736.
GeneID; 18291; -.
KEGG; mmu:18291; -.
UCSC; uc009bsp.1; mouse.
CTD; 135935; -.
MGI; MGI:108011; Nobox.
eggNOG; KOG0490; Eukaryota.
eggNOG; ENOG410YIJ3; LUCA.
GeneTree; ENSGT00650000093445; -.
HOGENOM; HOG000113810; -.
HOVERGEN; HBG082039; -.
InParanoid; Q8VIH1; -.
OMA; CLPELPF; -.
OrthoDB; EOG091G0ANP; -.
PhylomeDB; Q8VIH1; -.
TreeFam; TF337576; -.
PRO; PR:Q8VIH1; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000029736; -.
CleanEx; MM_NOBOX; -.
ExpressionAtlas; Q8VIH1; baseline and differential.
Genevisible; Q8VIH1; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IC:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IMP:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IDA:NTNU_SB.
GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISO:MGI.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR001356; Homeobox_dom.
Pfam; PF00046; Homeobox; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Homeobox; Nucleus; Oogenesis; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 527 Homeobox protein NOBOX.
/FTId=PRO_0000268866.
DNA_BIND 136 195 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 220 465 Pro-rich.
MUTAGEN 186 186 N->Q: Abolishes DNA-binding.
{ECO:0000269|PubMed:16997917}.
MUTAGEN 187 187 R->H: Abolishes DNA-binding.
{ECO:0000269|PubMed:17701902}.
MUTAGEN 192 192 R->Q: No effect on DNA-binding.
{ECO:0000269|PubMed:17701902}.
CONFLICT 323 326 SIAS -> RYGT (in Ref. 3; AAC52828).
{ECO:0000305}.
SEQUENCE 527 AA; 57565 MW; 1B6AF1323F785290 CRC64;
MEPTEKLCKK MQGQEAGDKP RTAALETEGP LQDSALPIQD DQDKQSSLPR ASLGKRPLSK
TSEELMDAGT CRVHKAPTAA ACGPQSEEEG CSPPERKAES LKPSISAVPG QATAGSLNSH
EGDLKKESLE VTCQFRKKTR TLYRSDQLEE LERIFQEDHY PDSDKRHEIS QMVGVTPQRI
MVWFQNRRAK WRKVEKLNEK ETKNGPAAPS ADSSQHRSAP ELLDPMPTDL EPGPVPPENI
LDVFPEPPML LTSEQTLTPF QNNEGAERVA VTPPLLSPPP IRRANLPLPL GPVQTPQVLP
PMRDVPGSDS IYKDKAYVSW GTSIASPPTY SNLEDLGSQD YQASSQLGSF QLSQAPHLPL
FPSLQSQFPY LPPFPYPIPS SMPFLPPEDS LFSFPFGFSG DSSQDYCPGP PPGQILLQPP
AENMGTGPWS GHCLPEPPFP RPHYPQALGQ PLGAEGYFPN LLPTPYALTM SKQSSLGLNG
LLEGTRVETG SSLSKMSDEQ TSSSLEQPAL EEVRDKNKNS HAAGAKE


Related products :

Catalog number Product name Quantity
EIAAB27447 Homeobox protein NOBOX,Homeodomain-containing protein OG-2,Mouse,Mus musculus,Newborn ovary homeobox protein,Nobox,Og2x,Oocyte-specific homeobox protein
EIAAB31191 Bft,Hindlimb-expressed homeobox protein backfoot,Homeobox protein PITX1,Homeobox protein P-OTX,Mouse,Mus musculus,Paired-like homeodomain transcription factor 1,Pituitary homeobox 1,Pituitary OTX-rela
EIAAB27309 Cardiac-specific homeobox,Csx,Homeobox protein CSX,Homeobox protein NK-2 homolog E,Homeobox protein Nkx-2.5,Mouse,Mus musculus,Nkx-2.5,Nkx2-5,Nkx2e
EIAAB37771 Homeobox OG-9,Homeobox protein SEBOX,Mouse,Mus musculus,Og9x,Sebox,Skin-, embryo-, brain- and oocyte-specific homeobox
EIAAB37769 Homeobox OG-9,Homeobox protein SEBOX,Og9x,Rat,Rattus norvegicus,Sebox,Skin-, embryo-, brain- and oocyte-specific homeobox
EIAAB37770 Homeobox OG-9,Homeobox protein SEBOX,Homo sapiens,Human,OG9X,SEBOX,Skin-, embryo-, brain- and oocyte-specific homeobox
18-003-42195 Homeobox protein SIX6 - Sine oculis homeobox homolog 6; Optic homeobox 2; Homeodomain protein OPTX2 Polyclonal 0.05 mg Aff Pur
EIAAB24840 hMix,Homeobox protein MIXL1,Homeodomain protein MIX,Homo sapiens,Human,Mix.1 homeobox-like protein,MIX1 homeobox-like protein 1,MIXL,MIXL1
EIAAB30960 Aristaless homeobox protein homolog,ARIX,ARIX1 homeodomain protein,Homo sapiens,Human,Paired mesoderm homeobox protein 2A,Paired-like homeobox 2A,PHOX2A,PMX2A
EIAAB30959 Aristaless homeobox protein homolog,Arix,ARIX1 homeodomain protein,Paired mesoderm homeobox protein 2A,Paired-like homeobox 2A,Phox2a,Pmx2a,Rat,Rattus norvegicus
EIAAB27310 Cardiac-specific homeobox,CSX,Homeobox protein CSX,Homeobox protein NK-2 homolog E,Homeobox protein Nkx-2.5,Homo sapiens,Human,NKX2.5,NKX2-5,NKX2E
EIAAB42542 Enteric neuron homeobox protein,Enx,Homeobox protein Hox-11L1,Homeobox TLX-2,Hox11L.1,Hox11l1,Mouse,Mus musculus,Ncx,PMUR10F,T-cell leukemia homeobox protein 2,Tlx1l1,Tlx2
EIAAB42544 Homeobox protein Hox-11L2,Homeobox TLX-3,Hox11l2,Mouse,Mus musculus,Respiratory neuron homeobox protein,Rnx,T-cell leukemia homeobox protein 3,Tlx1l2,Tlx3
EIAAB24841 Homeobox protein MIXL1,Homeodomain protein MIX,Mix,Mix.1 homeobox-like protein,MIX1 homeobox-like protein 1,Mixl1,mMix,Mml,Mouse,Mus musculus
EIAAB31193 BFT,Hindlimb-expressed homeobox protein backfoot,Homeobox protein PITX1,Homo sapiens,Human,Paired-like homeodomain transcription factor 1,Pituitary homeobox 1,PITX1,PTX1
EIAAB30961 Aristaless homeobox protein homolog,Arix,Mouse,Mus musculus,Paired mesoderm homeobox protein 2A,Paired-like homeobox 2A,Phox2,Phox2a,PHOX2A homeodomain protein,Pmx2,Pmx2a
EIAAB32588 Homeobox protein K-2,Homeobox protein mHox,Mouse,Mus musculus,Paired mesoderm homeobox protein 1,Paired-related homeobox protein 1,Pmx,Pmx1,Prrx1,PRX-1
EIAAB38535 Homeobox protein SIX6,Homeodomain protein OPTX2,Homo sapiens,Human,Optic homeobox 2,OPTX2,Sine oculis homeobox homolog 6,SIX6,SIX9
EIAAB26356 Early embryo specific expression NK-type homeobox protein,Ecat4,Enk,ES cell-associated protein 4,Homeobox protein NANOG,Homeobox transcription factor Nanog,Mouse,Mus musculus,Nanog
EIAAB11440 Beta protein 1,BP1,DLX4,DLX7,DLX8,DLX9,Homeobox protein DLX-4,Homeobox protein DLX-7,Homeobox protein DLX-8,Homo sapiens,Human
EIAAB42541 Homeobox protein Hox-11L1,Homo sapiens,HOX11L1,Human,NCX,Neural crest homeobox protein,T-cell leukemia homeobox protein 2,TLX2
EIAAB31197 ALL1-responsive protein ARP1,ARP1,Homeobox protein PITX2,Homo sapiens,Human,Paired-like homeodomain transcription factor 2,Pituitary homeobox 2,PITX2,RGS,RIEG,RIEG bicoid-related homeobox transcriptio
18-003-42354 Short stature homeobox protein 2 - Paired-related homeobox protein SHOT; Homeobox protein Og12X Polyclonal 0.1 mg Protein A
18-003-42354 Short stature homeobox protein 2 - Paired-related homeobox protein SHOT; Homeobox protein Og12X Polyclonal 0.05 mg Aff Pur
18-003-42353 Short stature homeobox protein 2 - Paired-related homeobox protein SHOT; Homeobox protein Og12X Polyclonal 0.1 mg Protein A


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur