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Homeobox protein Nkx-6.1 (Homeobox protein NK-6 homolog A)

 NKX61_MOUSE             Reviewed;         365 AA.
Q99MA9; B2RQP4; Q9ERQ7;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
12-SEP-2018, entry version 131.
RecName: Full=Homeobox protein Nkx-6.1;
AltName: Full=Homeobox protein NK-6 homolog A;
Name=Nkx6-1; Synonyms=Nkx6.1, Nkx6a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X DBA/2;
Sander M., Nelson S.B.;
"Isolation of partial cDNA sequence for the mouse homeodomain protein,
Nkx6.1.";
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-224.
STRAIN=129/Sv;
PubMed=10938085; DOI=10.1074/jbc.M004981200;
Watada H., Mirmira R.G., Leung J., German M.S.;
"Transcriptional and translational regulation of beta-cell
differentiation factor Nkx6.1.";
J. Biol. Chem. 275:34224-34230(2000).
[4]
DISRUPTION PHENOTYPE.
PubMed=11076772;
Sander M., Sussel L., Conners J., Scheel D., Kalamaras J.,
Dela Cruz F., Schwitzgebel V., Hayes-Jordan A., German M.;
"Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway
of beta-cell formation in the pancreas.";
Development 127:5533-5540(2000).
[5]
FUNCTION IN NEURAL PATTERNING, AND TISSUE SPECIFICITY.
PubMed=10830170; DOI=10.1016/S0092-8674(00)80853-3;
Briscoe J., Pierani A., Jessell T.M., Ericson J.;
"A homeodomain protein code specifies progenitor cell identity and
neuronal fate in the ventral neural tube.";
Cell 101:435-445(2000).
[6]
DISRUPTION PHENOTYPE.
PubMed=14973194; DOI=10.1073/pnas.0306233101;
Matsuoka T.A., Artner I., Henderson E., Means A., Sander M., Stein R.;
"The MafA transcription factor appears to be responsible for tissue-
specific expression of insulin.";
Proc. Natl. Acad. Sci. U.S.A. 101:2930-2933(2004).
-!- FUNCTION: Transcription factor which binds to specific A/T-rich
DNA sequences in the promoter regions of a number of genes.
Involved in transcriptional regulation in islet beta cells. Binds
to the insulin promoter and is involved in regulation of the
insulin gene. Together with NKX2-2 and IRX3 acts to restrict the
generation of motor neurons to the appropriate region of the
neural tube. Belongs to the class II proteins of neuronal
progenitor factors, which are induced by SHH signals.
{ECO:0000269|PubMed:10830170}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed by neuronal progenitor cells in
discrete domains of the ventral neural tube.
{ECO:0000269|PubMed:10830170}.
-!- DOMAIN: The C-terminal domain contributes to sequence-specific
DNA-binding.
-!- DISRUPTION PHENOTYPE: Dramatically diminished numbers of beta
cells within the pancreatic islets and secretion of insulin at
only 2% of normal levels. Loss of expression of Mafa, which is
involved in insulin gene transcription.
{ECO:0000269|PubMed:11076772, ECO:0000269|PubMed:14973194}.
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EMBL; AF357883; AAK37567.1; -; mRNA.
EMBL; BC138019; AAI38020.1; -; mRNA.
EMBL; BC138020; AAI38021.1; -; mRNA.
EMBL; AF291666; AAG30415.1; -; Genomic_DNA.
CCDS; CCDS19471.1; -.
RefSeq; NP_659204.1; NM_144955.2.
UniGene; Mm.193072; -.
ProteinModelPortal; Q99MA9; -.
SMR; Q99MA9; -.
STRING; 10090.ENSMUSP00000042716; -.
PhosphoSitePlus; Q99MA9; -.
PaxDb; Q99MA9; -.
PRIDE; Q99MA9; -.
Ensembl; ENSMUST00000044125; ENSMUSP00000042716; ENSMUSG00000035187.
GeneID; 18096; -.
KEGG; mmu:18096; -.
UCSC; uc008yim.1; mouse.
CTD; 4825; -.
MGI; MGI:1206039; Nkx6-1.
eggNOG; KOG0847; Eukaryota.
eggNOG; ENOG410XT1X; LUCA.
GeneTree; ENSGT00910000143996; -.
HOGENOM; HOG000060127; -.
HOVERGEN; HBG070987; -.
InParanoid; Q99MA9; -.
KO; K08030; -.
OMA; VGAMEGP; -.
OrthoDB; EOG091G142D; -.
PhylomeDB; Q99MA9; -.
TreeFam; TF327063; -.
PRO; PR:Q99MA9; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000035187; Expressed in 69 organ(s), highest expression level in dorsal pancreas.
Genevisible; Q99MA9; MM.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003682; F:chromatin binding; ISO:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
GO; GO:0030154; P:cell differentiation; IMP:MGI.
GO; GO:0008283; P:cell proliferation; ISO:MGI.
GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
GO; GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Ensembl.
GO; GO:0021953; P:central nervous system neuron differentiation; IMP:MGI.
GO; GO:0031018; P:endocrine pancreas development; IMP:MGI.
GO; GO:0045686; P:negative regulation of glial cell differentiation; IGI:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0022008; P:neurogenesis; ISO:MGI.
GO; GO:0001764; P:neuron migration; IEA:InterPro.
GO; GO:0048709; P:oligodendrocyte differentiation; IGI:MGI.
GO; GO:0045687; P:positive regulation of glial cell differentiation; IGI:MGI.
GO; GO:0032024; P:positive regulation of insulin secretion; ISO:MGI.
GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:MGI.
GO; GO:0030516; P:regulation of axon extension; IMP:MGI.
GO; GO:2001222; P:regulation of neuron migration; IMP:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:MGI.
GO; GO:0021912; P:regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; IGI:MGI.
GO; GO:0021913; P:regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; IMP:MGI.
GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
GO; GO:0007224; P:smoothened signaling pathway; IDA:MGI.
GO; GO:0006366; P:transcription by RNA polymerase II; ISO:MGI.
GO; GO:0003323; P:type B pancreatic cell development; IEA:Ensembl.
GO; GO:0044342; P:type B pancreatic cell proliferation; ISS:UniProtKB.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
InterPro; IPR000047; HTH_motif.
InterPro; IPR033630; NKX-6.1.
PANTHER; PTHR24340:SF31; PTHR24340:SF31; 1.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
PRINTS; PR00031; HTHREPRESSR.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Methylation; Nucleus; Reference proteome.
CHAIN 1 365 Homeobox protein Nkx-6.1.
/FTId=PRO_0000048953.
DNA_BIND 237 296 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
REGION 102 269 Repressor domain. {ECO:0000250}.
REGION 307 365 Involved in DNA-binding. {ECO:0000250}.
COMPBIAS 49 61 Poly-Ser.
COMPBIAS 119 132 Poly-Ser.
COMPBIAS 136 151 Poly-Ala.
COMPBIAS 169 174 Poly-Pro.
COMPBIAS 323 326 Poly-Asp.
MOD_RES 190 190 Asymmetric dimethylarginine.
{ECO:0000250|UniProtKB:P78426}.
SEQUENCE 365 AA; 37705 MW; B6AABAF5748A99E8 CRC64;
MLAVGAMEGP RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPTGPPSS SSSSSSSSSP
SPPLGSHNPG GLKPPAAGGL SSLGSPPQQL SAATPHGIND ILSRPSMPVA SGAALPSASP
SGSSSSSSSS ASATSASAAA AAAAAAAAAA ASSPAGLLAG LPRFSSLSPP PPPPGLYFSP
SAAAVAAVGR YPKPLAELPG RTPIFWPGVM QSPPWRDARL ACTPHQGSIL LDKDGKRKHT
RPTFSGQQIF ALEKTFEQTK YLAGPERARL AYSLGMTESQ VKVWFQNRRT KWRKKHAAEM
ATAKKKQDSE TERLKGTSEN EEDDDDYNKP LDPNSDDEKI TQLLKKHKSS GGSLLLHASE
AEGSS


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