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Homeobox protein SEBOX (Homeobox OG-9) (Homeobox transcription factor mezzo) (Skin-, embryo-, brain- and oocyte-specific homeobox)

 SEBOX_DANRE             Reviewed;         293 AA.
Q8JJ26; A2BIQ1;
13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
13-NOV-2007, sequence version 2.
23-MAY-2018, entry version 122.
RecName: Full=Homeobox protein SEBOX;
AltName: Full=Homeobox OG-9;
AltName: Full=Homeobox transcription factor mezzo;
AltName: Full=Skin-, embryo-, brain- and oocyte-specific homeobox;
Name=sebox; Synonyms=og9x; ORFNames=si:ch211-110p13.7;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY,
DEVELOPMENTAL STAGE, AND INDUCTION.
PubMed=12397099;
Poulain M., Lepage T.;
"Mezzo, a paired-like homeobox protein is an immediate target of Nodal
signalling and regulates endoderm specification in zebrafish.";
Development 129:4901-4914(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
-!- FUNCTION: Probable transcription factor involved in the control of
specification of mesoderm and endoderm. Acts in parallel with
bonnie and clyde, faust and casanova in the Nodal signaling
pathway. {ECO:0000269|PubMed:12397099}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00108}.
-!- TISSUE SPECIFICITY: Restricted to the mesendoderm precursors
during gastrulation. {ECO:0000269|PubMed:12397099}.
-!- DEVELOPMENTAL STAGE: First detected at sphere stage (4 hours) in a
small group of cells at the margin of the blastoderm. As epiboly
starts, it extends over the whole circumference of the margin of
the blastoderm, while it is not detected in the yolk syncytial
layer. Expression domain extends over 6 rows of cells, that is
over a region that includes the precursors of mesoderm and
endoderm. At the shield stage, it is also expressed in the
invaginating axial mesendoderm. After the shield stage, the
abundance of transcripts declines abruptly and only a weak
expression is detected in embryos at 60% epiboly and no expression
at 70% epiboly or later. Not detected in 4 day old embryos or in
adult fish. {ECO:0000269|PubMed:12397099}.
-!- INDUCTION: Regulated by the Nodal pathway.
{ECO:0000269|PubMed:12397099}.
-!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAM13128.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF466189; AAM22953.1; -; mRNA.
EMBL; BX957226; CAM13128.1; ALT_INIT; Genomic_DNA.
RefSeq; NP_001306981.1; NM_001320052.1.
UniGene; Dr.86794; -.
ProteinModelPortal; Q8JJ26; -.
SMR; Q8JJ26; -.
STRING; 7955.ENSDARP00000113809; -.
PaxDb; Q8JJ26; -.
PRIDE; Q8JJ26; -.
GeneID; 282666; -.
KEGG; dre:282666; -.
CTD; 645832; -.
ZFIN; ZDB-GENE-021206-4; sebox.
eggNOG; KOG0490; Eukaryota.
eggNOG; ENOG410YIJ3; LUCA.
HOGENOM; HOG000231518; -.
HOVERGEN; HBG089298; -.
InParanoid; Q8JJ26; -.
PhylomeDB; Q8JJ26; -.
TreeFam; TF315976; -.
PRO; PR:Q8JJ26; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0007492; P:endoderm development; IDA:ZFIN.
GO; GO:0003007; P:heart morphogenesis; IGI:ZFIN.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:ZFIN.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001356; Homeobox_dom.
Pfam; PF00046; Homeobox; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 293 Homeobox protein SEBOX.
/FTId=PRO_0000311339.
DNA_BIND 58 117 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
CONFLICT 138 138 H -> N (in Ref. 1; AAM22953).
{ECO:0000305}.
CONFLICT 146 146 S -> N (in Ref. 1; AAM22953).
{ECO:0000305}.
SEQUENCE 293 AA; 33386 MW; C751F0865F366E08 CRC64;
MALFYDQSFD LGLVQKINME TESDFIFNTN MLQFTDVTTK HMLSSPELDR TGHVEGQRKR
KRTIFSRAQL SELERAFMIT PYPDITLRER LAALTLLPES KIQVWFQNRR ARSMKSKKLI
TPVSRRSPAK DCTFPATHPD LNLEQSPEAN KSLRHHQQSL IRQALNPWPQ NRPPISPDLP
EILQWANRNS ETPGDSSFSS CPSERIQHPF PNQSSSVWQM NCFAAHPEGL KSYCTTSQAL
YSSVSVDQMI PAHPSSLEEA LQRQALTHYP QTSLGDISDL IYKAAVVTNL EEC


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