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Homeobox protein SIX3 (Sine oculis homeobox homolog 3)

 SIX3_MOUSE              Reviewed;         333 AA.
Q62233; P70176; P70177; Q4QQQ3;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
15-DEC-1998, sequence version 2.
22-NOV-2017, entry version 142.
RecName: Full=Homeobox protein SIX3;
AltName: Full=Sine oculis homeobox homolog 3;
Name=Six3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SIX3B).
STRAIN=BALB/cJ; TISSUE=Embryonic brain;
PubMed=8575305;
Oliver G., Mailhos A., Wehr R., Copeland N.G., Jenkins N.A., Gruss P.;
"Six3, a murine homologue of the sine oculis gene, demarcates the most
anterior border of the developing neural plate and is expressed during
eye development.";
Development 121:4045-4055(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SIX3A), AND NUCLEOTIDE SEQUENCE
[MRNA] OF 4-333 (ISOFORM SIX3B).
STRAIN=BALB/cJ;
PubMed=8814301; DOI=10.1016/0014-5793(96)00899-X;
Kawakami K., Ohto H., Takizawa T., Saito T.;
"Identification and expression of Six family genes in mouse retina.";
FEBS Lett. 393:259-263(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SIX3B).
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION IN OPTIC VESICLE MORPHOGENESIS, AND DEVELOPMENTAL STAGE.
PubMed=11458394; DOI=10.1002/dvdy.1148;
Lagutin O., Zhu C.C., Furuta Y., Rowitch D.H., McMahon A.P.,
Oliver G.;
"Six3 promotes the formation of ectopic optic vesicle-like structures
in mouse embryos.";
Dev. Dyn. 221:342-349(2001).
[5]
FUNCTION IN LENS DEVELOPMENT.
PubMed=11139622; DOI=10.1093/nar/29.2.515;
Lengler J., Krausz E., Tomarev S., Prescott A., Quinlan R.A., Graw J.;
"Antagonistic action of Six3 and Prox1 at the gamma-crystallin
promoter.";
Nucleic Acids Res. 29:515-526(2001).
[6]
FUNCTION, SUBCELLULAR LOCATION, INDUCTION, INTERACTION WITH AES AND
TLE4, AND MUTAGENESIS OF PHE-88.
PubMed=12050133;
Zhu C.C., Dyer M.A., Uchikawa M., Kondoh H., Lagutin O.V., Oliver G.;
"Six3-mediated auto repression and eye development requires its
interaction with members of the Groucho-related family of co-
repressors.";
Development 129:2835-2849(2002).
[7]
FUNCTION IN PROXIMAL/DISTAL AXIS SPECIFICATION.
PubMed=12163408;
Carl M., Loosli F., Wittbrodt J.;
"Six3 inactivation reveals its essential role for the formation and
patterning of the vertebrate eye.";
Development 129:4057-4063(2002).
[8]
FUNCTION IN LENS DEVELOPMENT, AND INDUCTION.
PubMed=12072567; DOI=10.1073/pnas.132195699;
Goudreau G., Petrou P., Reneker L.W., Graw J., Loster J., Gruss P.;
"Mutually regulated expression of Pax6 and Six3 and its implications
for the Pax6 haploinsufficient lens phenotype.";
Proc. Natl. Acad. Sci. U.S.A. 99:8719-8724(2002).
[9]
FUNCTION IN FOREBRAIN DEVELOPMENT, AND DISRUPTION PHENOTYPE.
PubMed=12569128; DOI=10.1101/gad.1059403;
Lagutin O.V., Zhu C.C., Kobayashi D., Topczewski J., Shimamura K.,
Puelles L., Russell H.R., McKinnon P.J., Solnica-Krezel L., Oliver G.;
"Six3 repression of Wnt signaling in the anterior neuroectoderm is
essential for vertebrate forebrain development.";
Genes Dev. 17:368-379(2003).
[10]
INTERACTION WITH EYA1, AND DEVELOPMENTAL STAGE.
PubMed=16024294; DOI=10.1016/j.modgep.2005.04.010;
Purcell P., Oliver G., Mardon G., Donner A.L., Maas R.L.;
"Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and
nasal placode induction.";
Gene Expr. Patterns 6:110-118(2005).
[11]
FUNCTION IN LENS INDUCTION, AND DISRUPTION PHENOTYPE.
PubMed=17066077; DOI=10.1038/sj.emboj.7601398;
Liu W., Lagutin O.V., Mende M., Streit A., Oliver G.;
"Six3 activation of Pax6 expression is essential for mammalian lens
induction and specification.";
EMBO J. 25:5383-5395(2006).
[12]
FUNCTION, INTERACTION WITH HDAC2 AND MTA1, AND MUTAGENESIS OF
233-ASN--SER-235.
PubMed=17666527; DOI=10.1073/pnas.0705878104;
Manavathi B., Peng S., Rayala S.K., Talukder A.H., Wang M.H.,
Wang R.A., Balasenthil S., Agarwal N., Frishman L.J., Kumar R.;
"Repression of Six3 by a corepressor regulates rhodopsin expression.";
Proc. Natl. Acad. Sci. U.S.A. 104:13128-13133(2007).
[13]
FUNCTION IN PROLIFERATION OF NEURAL PROGENITOR CELLS.
PubMed=17576749; DOI=10.1093/cercor/bhm092;
Appolloni I., Calzolari F., Corte G., Perris R., Malatesta P.;
"Six3 controls the neural progenitor status in the murine CNS.";
Cereb. Cortex 18:553-562(2008).
[14]
FUNCTION IN FOREBRAIN DEVELOPMENT, AND DISRUPTION PHENOTYPE.
PubMed=18094027; DOI=10.1242/dev.010082;
Lavado A., Lagutin O.V., Oliver G.;
"Six3 inactivation causes progressive caudalization and aberrant
patterning of the mammalian diencephalon.";
Development 135:441-450(2008).
[15]
FUNCTION IN PITUITARY DEVELOPMENT, AND DISRUPTION PHENOTYPE.
PubMed=18775421; DOI=10.1016/j.ydbio.2008.08.008;
Gaston-Massuet C., Andoniadou C.L., Signore M., Sajedi E., Bird S.,
Turner J.M., Martinez-Barbera J.P.;
"Genetic interaction between the homeobox transcription factors HESX1
and SIX3 is required for normal pituitary development.";
Dev. Biol. 324:322-333(2008).
[16]
FUNCTION IN FOREBRAIN DEVELOPMENT, DISRUPTION PHENOTYPE, AND
DEVELOPMENTAL STAGE.
PubMed=18694563; DOI=10.1016/j.devcel.2008.07.003;
Geng X., Speirs C., Lagutin O., Inbal A., Liu W., Solnica-Krezel L.,
Jeong Y., Epstein D.J., Oliver G.;
"Haploinsufficiency of Six3 fails to activate Sonic hedgehog
expression in the ventral forebrain and causes holoprosencephaly.";
Dev. Cell 15:236-247(2008).
[17]
INTERACTION WITH EYA4.
PubMed=19606496; DOI=10.1002/humu.21094;
Abe Y., Oka A., Mizuguchi M., Igarashi T., Ishikawa S., Aburatani H.,
Yokoyama S., Asahara H., Nagao K., Yamada M., Miyashita T.;
"EYA4, deleted in a case with middle interhemispheric variant of
holoprosencephaly, interacts with SIX3 both physically and
functionally.";
Hum. Mutat. 30:E946-E955(2009).
[18]
FUNCTION.
PubMed=20682799; DOI=10.1158/0008-5472.CAN-10-0909;
Kumar R., Balasenthil S., Manavathi B., Rayala S.K., Pakala S.B.;
"Metastasis-associated protein 1 and its short form variant stimulates
Wnt1 transcription through promoting its derepression from Six3
corepressor.";
Cancer Res. 70:6649-6658(2010).
[19]
FUNCTION IN NEURAL RETINA DEVELOPMENT.
PubMed=20890044; DOI=10.1172/JCI43219;
Liu W., Lagutin O., Swindell E., Jamrich M., Oliver G.;
"Neuroretina specification in mouse embryos requires Six3-mediated
suppression of Wnt8b in the anterior neural plate.";
J. Clin. Invest. 120:3568-3577(2010).
[20]
FUNCTION IN CELL MATURATION, AND TISSUE SPECIFICITY.
PubMed=22071110; DOI=10.1242/dev.067470;
Lavado A., Oliver G.;
"Six3 is required for ependymal cell maturation.";
Development 138:5291-5300(2011).
[21]
INDUCTION.
PubMed=23792023; DOI=10.1016/j.ydbio.2013.06.016;
Lee B., Song H., Rizzoti K., Son Y., Yoon J., Baek K., Jeong Y.;
"Genomic code for Sox2 binding uncovers its regulatory role in Six3
activation in the forebrain.";
Dev. Biol. 381:491-501(2013).
-!- FUNCTION: Transcriptional regulator which can act as both a
transcriptional repressor and activator by binding a ATTA
homeodomain core recognition sequence on these target genes.
During forebrain development represses WNT1 expression allowing
zona limitans intrathalamica formation and thereby ensuring proper
anterio-posterior patterning of the diencephalon and formation of
the rostral diencephalon (PubMed:18094027). Acts as a direct
upstream activator of SHH expression in the rostral diencephalon
ventral midline and that in turn SHH maintains its expression
(PubMed:18775421). In addition, Six3 activity is required for the
formation of the telencephalon. During postnatal stages of brain
development is necessary for ependymal cell maturation by
promoting the maturation of radial glia into ependymal cells
through regulation of neuroblast proliferation and migration
(PubMed:22071110). Acts on the proliferation and differentiation
of neural progenitor cells through activating transcription of
CCND1 AND CCND2 (PubMed:17576749). During early lens formation
plays a role in lens induction and specification by activating
directly PAX6 in the presumptive lens ectoderm (PubMed:17066077).
In turn PAX6 activates SIX3 resulting in activation of PDGFRA and
CCND1 promoting cell proliferation (PubMed:12072567). Also is
required for the neuroretina development by directly suppressing
WNT8B expression in the anterior neural plate territory
(PubMed:20890044). Its action during retina development and lens
morphogenesis is AES and TLE4-dependent manner. Furthermore,
during eye development regulates several genes expression. Before
and during early lens development represses the CRYGF promoter by
binding a SIX repressor element (PubMed:11139622). Directly
activates RHO transcription, or cooperates with CRX or NRL
(PubMed:17666527). Six3 functions also in the formation of the
proximodistal axis of the optic cup (PubMed:12163408), and
promotes the formation of optic vesicles-like structures
(PubMed:11458394). During pituitary development, acts in parallel
or alternatively with HESX1 to control cell proliferation through
Wnt/beta-catenin pathway (PubMed:18694563). Plays a role in eye
development by suppressing WNT1 expression and in dorsal-ventral
patterning by repressing BMP signaling pathway (By similarity).
{ECO:0000250|UniProtKB:O95343, ECO:0000269|PubMed:11139622,
ECO:0000269|PubMed:11458394, ECO:0000269|PubMed:12050133,
ECO:0000269|PubMed:12072567, ECO:0000269|PubMed:12163408,
ECO:0000269|PubMed:12569128, ECO:0000269|PubMed:17066077,
ECO:0000269|PubMed:17576749, ECO:0000269|PubMed:17666527,
ECO:0000269|PubMed:18094027, ECO:0000269|PubMed:18694563,
ECO:0000269|PubMed:18775421, ECO:0000269|PubMed:20682799,
ECO:0000269|PubMed:20890044, ECO:0000269|PubMed:22071110}.
-!- SUBUNIT: Interacts with EYA4; translocates EYA4 from the cytoplasm
to the nucleus and promotes activation of their target genes.
Interacts with MTA1 and HDAC2; represses its own transcription.
Interacts with MTA1; facilitates the binding of SIX3 to the core
DNA motif of SIX3 promoter. Interacts with EYA1; promotes EYA1
translocation to the nucleus. Interacts with TLE1 and AES (via Q
domain); can act in combination with either TLE1 and/or AES
leading to transcriptional repression or activation, respectively
(By similarity). Interacts (via homeobox) with NR4A3;
differentially regulates the transcriptional activities NR4A3 (By
similarity). Interacts with GMNN (By similarity). Interacts with
TLE4. {ECO:0000250|UniProtKB:O95343, ECO:0000269|PubMed:12050133,
ECO:0000269|PubMed:16024294, ECO:0000269|PubMed:17666527,
ECO:0000269|PubMed:19606496}.
-!- INTERACTION:
P63002:Aes; NbExp=5; IntAct=EBI-2297327, EBI-646888;
P16371:gro (xeno); NbExp=2; IntAct=EBI-2297327, EBI-153866;
P70288:Hdac2; NbExp=2; IntAct=EBI-2297327, EBI-302251;
Q8K4B0:Mta1; NbExp=2; IntAct=EBI-2297327, EBI-1216353;
Q62441:Tle4; NbExp=2; IntAct=EBI-2297327, EBI-2297871;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00108, ECO:0000269|PubMed:12050133}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=SIX3B {ECO:0000303|PubMed:8814301};
IsoId=Q62233-1; Sequence=Displayed;
Name=SIX3A {ECO:0000303|PubMed:8814301};
IsoId=Q62233-2; Sequence=VSP_002291, VSP_002292;
-!- TISSUE SPECIFICITY: Expressed in ependymal cells during the
formation of the lateral wall. {ECO:0000269|PubMed:22071110}.
-!- DEVELOPMENTAL STAGE: Expressed in the developing retina (at
protein level). First expressed at E6.5 of embryo development
around the anterior border. At E8.5, expression is found over the
anterior neural plate. At E9.5, in the diencephalic part of the
ventral forebrain, optic vesicles, olfactory placodes and Rathke
pouch. In later stages, present in hypothalamus, eyes and
pituitary. Expression at around E7.5 to E8 is high in the anterior
neural ectoderm. Weaker expression is detected in the prechordal
plate. At the 5 somite stage (E8.0), expression is maintained in
the anterior neural ectoderm. Around the 8 somite stage (E8.0),
expression is already restricted to the ventral forebrain and eye
field. At the 12 somite stage (E8.5), expression is maintained in
the ventral forebrain (PubMed:18694563). At E9.5 strongly
expressed throughout the prospective nasal ectoderm. At E10.5
remains expressed throughout the nasal ectoderm (PubMed:16024294).
At E7.5 expression is found in the developing anterior
neuroectoderm. At E9.0 expression is found in the region of the
presumptive lens ectoderm and developing optic vesicle. At E9.5
expression is found in the lens placode, optic vesicles, and
ventral forebrain (PubMed:11458394). {ECO:0000269|PubMed:11458394,
ECO:0000269|PubMed:16024294, ECO:0000269|PubMed:18694563}.
-!- INDUCTION: Represses its own transcription in a TLE4-dependent
manner. Induces in lens by PAX6 in a dosage-dependent manner.
Activated by SOX2 during forebrain development. Inhibited by MTA1
in mammary glands. {ECO:0000269|PubMed:12050133,
ECO:0000269|PubMed:12072567, ECO:0000269|PubMed:23792023}.
-!- DISRUPTION PHENOTYPE: Embryos die at birth and lack most head
structures anterior to the midbrain, including the eyes and nose
(PubMed:12569128). Embryonic SHH and SIX3 double heterozygous mice
exibit a semilobar holoprosencephaly-like phenotype and a
dorsoventral patterning defects in telencephalon
(PubMed:18694563). Embryonic WNT1 and SIX3 double homozygous mice
lack cerebellum and colliculus and have a severely reduced
midbrain (PubMed:18094027). Conditional knockout in eye exibit
drastically reduced lens size, cataracts, or absence of the lens
(PubMed:17066077). Embryo of SIX3 and HESX1 heterozygous mice
exhibit severe growth retardation after weaning, with additional
gonadal and thyroid gland defects, resulting in a lethal phenotype
(PubMed:18775421). {ECO:0000269|PubMed:12569128,
ECO:0000269|PubMed:17066077, ECO:0000269|PubMed:18094027,
ECO:0000269|PubMed:18694563, ECO:0000269|PubMed:18775421}.
-!- SIMILARITY: Belongs to the SIX/Sine oculis homeobox family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA62379.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Sequence=CAA62379.1; Type=Frameshift; Positions=117, 119, 277; Evidence={ECO:0000305};
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EMBL; X90871; CAA62379.1; ALT_SEQ; mRNA.
EMBL; D83144; BAA11822.1; -; mRNA.
EMBL; D83145; BAA11823.1; -; mRNA.
EMBL; BC098096; AAH98096.1; -; mRNA.
CCDS; CCDS50203.1; -. [Q62233-1]
PIR; S74255; S74255.
RefSeq; NP_035511.2; NM_011381.4. [Q62233-1]
UniGene; Mm.370208; -.
UniGene; Mm.391586; -.
ProteinModelPortal; Q62233; -.
SMR; Q62233; -.
BioGrid; 203261; 4.
DIP; DIP-46499N; -.
IntAct; Q62233; 5.
STRING; 10090.ENSMUSP00000135677; -.
iPTMnet; Q62233; -.
PhosphoSitePlus; Q62233; -.
PaxDb; Q62233; -.
PRIDE; Q62233; -.
Ensembl; ENSMUST00000175898; ENSMUSP00000135677; ENSMUSG00000038805. [Q62233-1]
Ensembl; ENSMUST00000176081; ENSMUSP00000135312; ENSMUSG00000038805. [Q62233-1]
GeneID; 20473; -.
KEGG; mmu:20473; -.
UCSC; uc008dub.2; mouse. [Q62233-1]
CTD; 6496; -.
MGI; MGI:102764; Six3.
eggNOG; KOG0775; Eukaryota.
eggNOG; ENOG410XRPB; LUCA.
GeneTree; ENSGT00540000070251; -.
HOVERGEN; HBG003609; -.
InParanoid; Q62233; -.
KO; K19473; -.
TreeFam; TF315545; -.
PRO; PR:Q62233; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000038805; -.
ExpressionAtlas; Q62233; baseline and differential.
Genevisible; Q62233; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.
GO; GO:0005102; F:receptor binding; IEA:Ensembl.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
GO; GO:0001222; F:transcription corepressor binding; IPI:UniProtKB.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; IDA:NTNU_SB.
GO; GO:1902742; P:apoptotic process involved in development; IMP:UniProtKB.
GO; GO:0007420; P:brain development; IMP:MGI.
GO; GO:0043010; P:camera-type eye development; IGI:MGI.
GO; GO:0021846; P:cell proliferation in forebrain; IMP:UniProtKB.
GO; GO:0048512; P:circadian behavior; IMP:MGI.
GO; GO:0021536; P:diencephalon development; IGI:MGI.
GO; GO:0002070; P:epithelial cell maturation; IMP:UniProtKB.
GO; GO:0001654; P:eye development; IDA:MGI.
GO; GO:0021797; P:forebrain anterior/posterior pattern specification; IMP:MGI.
GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; ISS:UniProtKB.
GO; GO:0002088; P:lens development in camera-type eye; IDA:UniProtKB.
GO; GO:1990086; P:lens fiber cell apoptotic process; IDA:UniProtKB.
GO; GO:0070306; P:lens fiber cell differentiation; IDA:UniProtKB.
GO; GO:0060235; P:lens induction in camera-type eye; IMP:MGI.
GO; GO:0045665; P:negative regulation of neuron differentiation; IDA:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IMP:MGI.
GO; GO:0014016; P:neuroblast differentiation; IMP:UniProtKB.
GO; GO:0097402; P:neuroblast migration; IMP:UniProtKB.
GO; GO:0003404; P:optic vesicle morphogenesis; IDA:UniProtKB.
GO; GO:0021983; P:pituitary gland development; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:NTNU_SB.
GO; GO:0006606; P:protein import into nucleus; IDA:MGI.
GO; GO:0000060; P:protein import into nucleus, translocation; IDA:UniProtKB.
GO; GO:0009946; P:proximal/distal axis specification; IDA:UniProtKB.
GO; GO:1901987; P:regulation of cell cycle phase transition; IDA:UniProtKB.
GO; GO:0042127; P:regulation of cell proliferation; IMP:UniProtKB.
GO; GO:2000177; P:regulation of neural precursor cell proliferation; IDA:UniProtKB.
GO; GO:0061074; P:regulation of neural retina development; IMP:UniProtKB.
GO; GO:1902692; P:regulation of neuroblast proliferation; IMP:UniProtKB.
GO; GO:0021537; P:telencephalon development; IMP:UniProtKB.
GO; GO:0021978; P:telencephalon regionalization; IMP:UniProtKB.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR031701; SIX1_SD.
InterPro; IPR032949; SIX3.
PANTHER; PTHR10390:SF31; PTHR10390:SF31; 1.
Pfam; PF00046; Homeobox; 1.
Pfam; PF16878; SIX1_SD; 1.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Developmental protein;
DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
Transcription; Transcription regulation.
CHAIN 1 333 Homeobox protein SIX3.
/FTId=PRO_0000049300.
DNA_BIND 207 266 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
REGION 73 120 Interaction with AES.
{ECO:0000269|PubMed:12050133}.
REGION 233 235 Bind to RHO promoter.
{ECO:0000269|PubMed:17666527}.
COMPBIAS 33 70 Gly-rich. {ECO:0000255|PROSITE-
ProRule:PRU00008}.
VAR_SEQ 271 284 LQHQAIGPSGMRSL -> SVAGTAARPPQAPG (in
isoform SIX3A). {ECO:0000305}.
/FTId=VSP_002291.
VAR_SEQ 285 333 Missing (in isoform SIX3A).
{ECO:0000305}.
/FTId=VSP_002292.
MUTAGEN 88 88 F->E: Loss of interaction with AES and
TLE4. {ECO:0000269|PubMed:12050133}.
MUTAGEN 233 235 Missing: Suppression of SIX3-binding to
rhodopsin promoter. Impairs the ability
of Six3 to stimulate RHO transcription.
{ECO:0000269|PubMed:17666527}.
CONFLICT 44 44 G -> GG (in Ref. 1; CAA62379).
{ECO:0000305}.
CONFLICT 283 283 S -> C (in Ref. 1; CAA62379).
{ECO:0000305}.
SEQUENCE 333 AA; 35593 MW; 1AD7D3C4388043B9 CRC64;
MVFRSPLDLY SSHFLLPNFA DSHHCSLLLA SSGGGSGASG GGGGAGGGGG GNRAGGGGAG
GAGGGSGGGG SRAPPEELSM FQLPTLNFSP EQVASVCETL EETGDIERLG RFLWSLPVAP
GACEAINKHE SILRARAVVA FHTGNFRDLY HILENHKFTK ESHGKLQAMW LEAHYQEAEK
LRGRPLGPVD KYRVRKKFPL PRTIWDGEQK THCFKERTRS LLREWYLQDP YPNPSKKREL
AQATGLTPTQ VGNWFKNRRQ RDRAAAAKNR LQHQAIGPSG MRSLAEPGCP THGSAESPST
AASPTTSVSS LTERADTGTS ILSVTSSDSE CDV


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EIAAB38535 Homeobox protein SIX6,Homeodomain protein OPTX2,Homo sapiens,Human,Optic homeobox 2,OPTX2,Sine oculis homeobox homolog 6,SIX6,SIX9
EIAAB38536 Homeobox protein SIX6,Mouse,Mus musculus,Optic homeobox 2,Optx2,Sine oculis homeobox homolog 6,Six6,Six9,Six9 protein
EIAAB38524 Homeobox protein SIX1,Homo sapiens,Human,Sine oculis homeobox homolog 1,SIX1
EIAAB38527 Homeobox protein SIX2,Homo sapiens,Human,Sine oculis homeobox homolog 2,SIX2
EIAAB38531 Homeobox protein SIX4,Homo sapiens,Human,Sine oculis homeobox homolog 4,SIX4
EIAAB38526 Homeobox protein SIX2,Mouse,Mus musculus,Sine oculis homeobox homolog 2,Six2
EIAAB38525 Homeobox protein SIX1,Mouse,Mus musculus,Sine oculis homeobox homolog 1,Six1
EIAAB38533 DM locus-associated homeodomain protein homolog,Dmahp,Homeobox protein SIX5,Mouse,Mus musculus,Sine oculis homeobox homolog 5,Six5
EIAAB38534 DM locus-associated homeodomain protein,DMAHP,Homeobox protein SIX5,Homo sapiens,Human,Sine oculis homeobox homolog 5,SIX5
25-062 SIX3 belongs to the SIX_Sine oculis homeobox family. It contains 1 homeobox DNA-binding domain. SIX3 may be involved in visual system development. 0.05 mg
EIAAB38537 Chicken,Gallus gallus,Homeobox protein SIX6,Optic homeobox 2,OPTX2,Sine oculis homeobox homolog 6,SIX6,SIX9,Six9 protein
EIAAB38532 Arec3,Homeobox protein SIX4,Mouse,Mus musculus,Sine oculis homeobox homolog 4,Six4,Skeletal muscle-specific ARE-binding protein AREC3
GWB-DC04F7 Anti- SIX6 (sine oculis homeobox homolog 6 (Drosophila)) Antibody
25-488 This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. SIX2 is a transcription factor which, like other members of this 0.05 mg
EIAAB27309 Cardiac-specific homeobox,Csx,Homeobox protein CSX,Homeobox protein NK-2 homolog E,Homeobox protein Nkx-2.5,Mouse,Mus musculus,Nkx-2.5,Nkx2-5,Nkx2e
25-063 SIX1 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb develop 0.05 mg
EIAAB27320 Bagpipe homeobox protein homolog 1,BAPX1,Homeobox protein NK-3 homolog B,Homeobox protein Nkx-3.2,Homo sapiens,Human,NKX3-2,NKX3B
EIAAB27319 Bagpipe homeobox protein homolog 1,Bapx1,Homeobox protein NK-3 homolog B,Homeobox protein Nkx-3.2,Mouse,Mus musculus,Nkx-3.2,Nkx3-2,Nkx3b
EIAAB27310 Cardiac-specific homeobox,CSX,Homeobox protein CSX,Homeobox protein NK-2 homolog E,Homeobox protein Nkx-2.5,Homo sapiens,Human,NKX2.5,NKX2-5,NKX2E
18-003-43167 Diencephalon_mesencephalon homeobox protein 1 - Diencephalon_mesencephalon-expressed brain homeobox gene 1 protein; Paired-like homeobox protein DMBX1; Paired-type homeobox Atx; Orthodenticle homolog 0.05 mg Aff Pur
SIX3_MOUSE ELISA Kit FOR Homeobox protein SIX3; organism: Mouse; gene name: Six3 96T


 

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