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Homeobox protein mab-5 (Protein male abnormal 5)

 MAB5_CAEEL              Reviewed;         200 AA.
P10038; Q9GZ02;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
27-MAY-2002, sequence version 3.
22-NOV-2017, entry version 151.
RecName: Full=Homeobox protein mab-5;
AltName: Full=Protein male abnormal 5;
Name=mab-5 {ECO:0000312|WormBase:C08C3.3};
ORFNames=C08C3.3 {ECO:0000312|WormBase:C08C3.3};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=2903796; DOI=10.1016/0092-8674(88)90131-6;
Costa M., Wir M., Coulson A., Sulston J., Kenyon C.;
"Posterior pattern formation in C. elegans involves position-specific
expression of a gene containing a homeobox.";
Cell 55:747-756(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Grandien K., Sommer R.J.;
"Determination of 5'-end of Caenorhabditis elegans mab-5 cDNA
demonstrates a shorter N-terminal region than previously predicted.";
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=7906398; DOI=10.1038/368032a0;
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M.,
Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A.,
Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A.,
Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M.,
Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N.,
Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M.,
Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R.,
Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R.,
Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K.,
Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J.,
Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
elegans.";
Nature 368:32-38(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[5]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=8898225;
Harris J., Honigberg L., Robinson N., Kenyon C.;
"Neuronal cell migration in C. elegans: regulation of Hox gene
expression and cell position.";
Development 122:3117-3131(1996).
[6]
TISSUE SPECIFICITY.
PubMed=15371357; DOI=10.1534/genetics.104.031781;
Forrester W.C., Kim C., Garriga G.;
"The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt
signaling in cell migration.";
Genetics 168:1951-1962(2004).
[7]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21307099; DOI=10.1242/dev.062240;
Tian C., Shi H., Colledge C., Stern M., Waterston R., Liu J.;
"The C. elegans SoxC protein SEM-2 opposes differentiation factors to
promote a proliferative blast cell fate in the postembryonic
mesoderm.";
Development 138:1033-1043(2011).
[8]
FUNCTION.
PubMed=23784779; DOI=10.1073/pnas.1301849110;
Wang X., Zhou F., Lv S., Yi P., Zhu Z., Yang Y., Feng G., Li W.,
Ou G.;
"Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to
the cell polarity in neuronal migration.";
Proc. Natl. Acad. Sci. U.S.A. 110:11175-11180(2013).
-!- FUNCTION: Transcription factor that binds to the promoter region
of the transcription factor lin-39 to repress its expression in Q
neuroblasts and thereby direct left Q neuroblast (QL) daughter
cell migration (PubMed:8898225, PubMed:23784779). During
postembryonic development, required for posterior-specific pattern
formation (PubMed:2903796). Within the posterior body region,
controls epidermal, neuronal, and mesodermal cell differentiation
(PubMed:2903796, PubMed:21307099). {ECO:0000269|PubMed:21307099,
ECO:0000269|PubMed:23784779, ECO:0000269|PubMed:2903796,
ECO:0000269|PubMed:8898225}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed asymmetrically in the QL neuroblast.
{ECO:0000269|PubMed:15371357}.
-!- DISRUPTION PHENOTYPE: Defective QL neuroblast daughter cell
migration (PubMed:8898225). Lin-39 and mab-5 double mutants have
reduced sex myoblast specific expression of sem-2 in the
developing mesoderm (PubMed:21307099).
{ECO:0000269|PubMed:21307099, ECO:0000269|PubMed:8898225}.
-!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA28106.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; M22751; AAA28106.1; ALT_INIT; mRNA.
EMBL; AF277990; AAG00458.1; -; mRNA.
EMBL; FO080429; CCD63641.1; -; Genomic_DNA.
PIR; S44615; S44615.
RefSeq; NP_498695.1; NM_066294.5.
UniGene; Cel.18387; -.
ProteinModelPortal; P10038; -.
SMR; P10038; -.
BioGrid; 41299; 3.
IntAct; P10038; 7.
MINT; MINT-1123728; -.
STRING; 6239.C08C3.3; -.
EPD; P10038; -.
PaxDb; P10038; -.
PeptideAtlas; P10038; -.
EnsemblMetazoa; C08C3.3; C08C3.3; WBGene00003102.
GeneID; 176091; -.
KEGG; cel:CELE_C08C3.3; -.
UCSC; C08C3.3; c. elegans.
CTD; 176091; -.
WormBase; C08C3.3; CE25765; WBGene00003102; mab-5.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
GeneTree; ENSGT00900000140792; -.
HOGENOM; HOG000231181; -.
InParanoid; P10038; -.
KO; K09311; -.
OMA; FAYNPLQ; -.
OrthoDB; EOG091G09XD; -.
PhylomeDB; P10038; -.
SignaLink; P10038; -.
PRO; PR:P10038; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00003102; -.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IDA:WormBase.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:WormBase.
GO; GO:0051179; P:localization; IMP:WormBase.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:WormBase.
GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
GO; GO:0097402; P:neuroblast migration; IGI:UniProtKB.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:WormBase.
GO; GO:0048337; P:positive regulation of mesodermal cell fate specification; IGI:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:WormBase.
GO; GO:0042659; P:regulation of cell fate specification; IMP:WormBase.
GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001827; Homeobox_Antennapedia_CS.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00032; ANTENNAPEDIA; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 200 Homeobox protein mab-5.
/FTId=PRO_0000049171.
DNA_BIND 115 175 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOTIF 103 108 Antp-type hexapeptide.
COMPBIAS 19 44 Ala/Ser/Thr-rich.
COMPBIAS 38 44 Poly-Ala.
SEQUENCE 200 AA; 22399 MW; EAC2DCA86F54E7E3 CRC64;
MSMYPGWTGD DSYWAGAGTT ASSQSASSGT SASASSSAAA AAAANNLKTY ELYNHTYMNN
MKHMLAAGWM DNSSNPFAYN PLQATSANFG ETRTSMPAIS QPVFPWMKMG GAKGGESKRT
RQTYSRSQTL ELEKEFHYHK YLTRKRRQEI SETLHLTERQ VKIWFQNRRM KHKKEAKGEG
GSNESDEESN QDEQNEQHSS


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