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Homeotic protein labial (F24) (F90-2)

 LAB_DROME               Reviewed;         635 AA.
P10105; O97065;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
28-NOV-2002, sequence version 2.
23-MAY-2018, entry version 178.
RecName: Full=Homeotic protein labial;
AltName: Full=F24;
AltName: Full=F90-2;
Name=lab; ORFNames=CG1264;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=Oregon-R; TISSUE=Embryo;
PubMed=2461299;
Mlodzik M., Fjose A., Gehring W.J.;
"Molecular structure and spatial expression of a homeobox gene from
the labial region of the Antennapedia-complex.";
EMBO J. 7:2569-2578(1988).
[2]
NUCLEOTIDE SEQUENCE (ISOFORM SHORT), AND CHARACTERIZATION.
STRAIN=Canton-S, and Oregon-R; TISSUE=Embryo;
PubMed=2566560; DOI=10.1101/gad.3.3.399;
Diederich R.J., Merrill V.K.L., Pultz M.A., Kaufman T.C.;
"Isolation, structure, and expression of labial, a homeotic gene of
the Antennapedia Complex involved in Drosophila head development.";
Genes Dev. 3:399-414(1989).
[3]
NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
STRAIN=Berkeley;
Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A.,
Palazzolo M.J.;
"Complete sequence of the Antennapedia complex of Drosophila.";
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM SHORT).
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[5]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
STRAIN=Berkeley; TISSUE=Embryo;
PubMed=10731138; DOI=10.1126/science.287.5461.2222;
Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E.,
Stapleton M., Harvey D.A.;
"A Drosophila complementary DNA resource.";
Science 287:2222-2224(2000).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-567, AND TISSUE SPECIFICITY.
STRAIN=Canton-S;
PubMed=3014511; DOI=10.1073/pnas.83.13.4809;
Hoey T., Doyle H.J., Harding K., Wedeen C., Levine M.;
"Homeo box gene expression in anterior and posterior regions of the
Drosophila embryo.";
Proc. Natl. Acad. Sci. U.S.A. 83:4809-4813(1986).
-!- FUNCTION: Sequence-specific transcription factor which is part of
a developmental regulatory system that provides cells with
specific positional identities on the anterior-posterior axis.
Required for proper head development.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long;
IsoId=P10105-1; Sequence=Displayed;
Name=Short;
IsoId=P10105-2; Sequence=VSP_002397;
-!- TISSUE SPECIFICITY: During embryogenesis, expressed in mandibular
lobe, hypopharyngeal organ, neural and epidermal cells of
procephalic lobe, sensory cells of clypeolabrum, posterior midgut,
thoracic and abdominal segments. {ECO:0000269|PubMed:2461299,
ECO:0000269|PubMed:3014511}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
High expression in embryos and third instar larvae, lower
expression in pupae. {ECO:0000269|PubMed:2461299}.
-!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
{ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1, Met-2 or Met-7 is the
initiator. {ECO:0000305}.
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EMBL; X13103; CAA31495.1; -; mRNA.
EMBL; X13104; CAB57786.1; -; Genomic_DNA.
EMBL; X13105; CAB57786.1; JOINED; Genomic_DNA.
EMBL; X13106; CAB57786.1; JOINED; Genomic_DNA.
EMBL; X13104; CAB57787.1; -; Genomic_DNA.
EMBL; X13105; CAB57787.1; JOINED; Genomic_DNA.
EMBL; X13106; CAB57787.1; JOINED; Genomic_DNA.
EMBL; AE001572; AAD19811.1; -; Genomic_DNA.
EMBL; AE014297; AAF54098.1; -; Genomic_DNA.
EMBL; AY095089; AAM11417.1; -; mRNA.
EMBL; M13570; AAA28610.1; -; Genomic_DNA.
PIR; A30168; A30168.
PIR; S01164; S01164.
RefSeq; NP_476613.1; NM_057265.4. [P10105-2]
UniGene; Dm.4752; -.
ProteinModelPortal; P10105; -.
SMR; P10105; -.
BioGrid; 66015; 10.
DIP; DIP-59868N; -.
IntAct; P10105; 1.
STRING; 7227.FBpp0081194; -.
PaxDb; P10105; -.
PRIDE; P10105; -.
EnsemblMetazoa; FBtr0081696; FBpp0081194; FBgn0002522. [P10105-2]
GeneID; 40817; -.
KEGG; dme:Dmel_CG1264; -.
UCSC; CG1264-RA; d. melanogaster. [P10105-1]
CTD; 40817; -.
FlyBase; FBgn0002522; lab.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
GeneTree; ENSGT00910000144005; -.
HOGENOM; HOG000263879; -.
InParanoid; P10105; -.
KO; K09301; -.
OMA; WMQLKRN; -.
OrthoDB; EOG091G0CC9; -.
GenomeRNAi; 40817; -.
PRO; PR:P10105; -.
Proteomes; UP000000803; Chromosome 3R.
Bgee; FBgn0002522; -.
ExpressionAtlas; P10105; baseline and differential.
Genevisible; P10105; DM.
GO; GO:0005634; C:nucleus; IDA:FlyBase.
GO; GO:0035326; F:enhancer binding; IPI:FlyBase.
GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0007420; P:brain development; IMP:FlyBase.
GO; GO:0035284; P:brain segmentation; IGI:FlyBase.
GO; GO:0030154; P:cell differentiation; TAS:FlyBase.
GO; GO:0001709; P:cell fate determination; TAS:FlyBase.
GO; GO:0060323; P:head morphogenesis; IMP:FlyBase.
GO; GO:0007494; P:midgut development; TAS:FlyBase.
GO; GO:0090098; P:positive regulation of decapentaplegic signaling pathway; IMP:FlyBase.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Developmental protein;
DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 635 Homeotic protein labial.
/FTId=PRO_0000200262.
DNA_BIND 507 566 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 11 18 His-rich.
COMPBIAS 42 64 Gln-rich.
COMPBIAS 96 111 Gln-rich.
COMPBIAS 129 134 Ser/Thr-rich.
COMPBIAS 191 196 Gln-rich.
COMPBIAS 306 339 Gln/His-rich.
COMPBIAS 361 370 Ser/Thr-rich.
VAR_SEQ 406 411 Missing (in isoform Short).
{ECO:0000303|PubMed:10731138}.
/FTId=VSP_002397.
CONFLICT 31 31 S -> A (in Ref. 2). {ECO:0000305}.
CONFLICT 46 46 P -> H (in Ref. 2). {ECO:0000305}.
CONFLICT 139 139 T -> K (in Ref. 1; CAB57786/CAB57787).
{ECO:0000305}.
CONFLICT 444 444 G -> D (in Ref. 1; CAA31495/CAB57786/
CAB57787). {ECO:0000305}.
CONFLICT 447 447 N -> S (in Ref. 1 and 2). {ECO:0000305}.
SEQUENCE 635 AA; 68154 MW; B39A58813F4D5778 CRC64;
MMDVSSMYGN HPHHHHPHAN AYDGYSTTTA SAANASSYFA PQQHQPHLQL QQQQQHQHLQ
QPQQHLTYNG YESSSPGNYY PQQQAQLTPP PTSSHQVVQQ HQQQQQAQQQ QLYPHSHLFS
PSAAEYGITT STTTGNPGTP LHPSSHSPAD SYYESDSVHS YYATAAVATV APPSNSSPIT
AANASATSNT QQQQQQAAII SSENGMMYTN LDCMYPTAQA QAPVHGYAGQ IEEKYAAVLH
ASYAPGMVLE DQDPMMQQAT QSQMWHHQQH LAGSYALDAM DSLGMHAHMH HGLPHGHLGN
LANNPHQQQP QVQQQQQQPH QQPQHPQNQS PAAHQQHHQN SVSPNGGMNR QQRGGVISPG
SSTSSSTSAS NGAHPASTQS KSPNHSSSIP TYKWMQLKRN VPKPQAPSYL PAPKLPASGI
ASMHDYQMNG QLDMCRGGGG GGSGVGNGPV GVGGNGSPGI GGVLSVQNSL IMANSAAAAG
SAHPNGMGVG LGSGSGLSSC SLSSNTNNSG RTNFTNKQLT ELEKEFHFNR YLTRARRIEI
ANTLQLNETQ VKIWFQNRRM KQKKRVKEGL IPADILTQHS TSVISEKPPQ QQQPQPPELQ
LKSQGSDLGG NELATGAPST PTTAMTLTAP TSKQS


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