Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2)

 HOME2_RAT               Reviewed;         354 AA.
O88801; O88802;
28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
28-MAR-2018, entry version 126.
RecName: Full=Homer protein homolog 2;
Short=Homer-2;
AltName: Full=Cupidin;
AltName: Full=VASP/Ena-related gene up-regulated during seizure and LTP 2;
Short=Vesl-2;
Name=Homer2; Synonyms=Vesl2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
PubMed=9727012; DOI=10.1074/jbc.273.37.23969;
Kato A., Ozawa F., Saitoh Y., Fukazawa Y., Sugiyama H., Inokuchi K.;
"Novel members of the Vesl/Homer family of PDZ-proteins that bind
metabotropic glutamate receptors.";
J. Biol. Chem. 273:23969-23975(1998).
[2]
INTERACTION WITH AGAP2.
PubMed=14528310; DOI=10.1038/nn1134;
Rong R., Ahn J.-Y., Huang H., Nagata E., Kalman D., Kapp J.A., Tu J.,
Worley P.F., Snyder S.H., Ye K.;
"PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase,
preventing neuronal apoptosis.";
Nat. Neurosci. 6:1153-1161(2003).
-!- FUNCTION: Postsynaptic density scaffolding protein. Binds and
cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1,
RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with
ER-associated ITPR1 receptors, it aids the coupling of surface
receptors to intracellular calcium release. May also couple GRM1
to PI3 kinase through its interaction with AGAP2. Isoforms can be
differently regulated and may play an important role in
maintaining the plasticity at glutamatergic synapses. Required for
normal hearing (By similarity). {ECO:0000250|UniProtKB:Q9NSB8}.
-!- SUBUNIT: Isoform 1 and isoform 2 encode coiled-coil structures
that mediate homo- and heteromultimerization.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NSB8}.
Cell junction, synapse, postsynaptic cell membrane, postsynaptic
density. Cell junction, synapse. Cell projection, stereocilium
{ECO:0000250|UniProtKB:Q9QWW1}. Note=Postsynaptic density of
neuronal cells. The stabilization and clustering of the
metabotropic glutamate receptors appears to be mediated by isoform
1 and isoform 2 at the cell surface.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O88801-1; Sequence=Displayed;
Name=2; Synonyms=Vesl-2(delta 11);
IsoId=O88801-2; Sequence=VSP_009072;
-!- TISSUE SPECIFICITY: Constitutively expressed in the adult
hippocampus.
-!- DEVELOPMENTAL STAGE: In the developing hippocampus, expression is
high at P8, then decreased along with hippocampal development.
-!- DOMAIN: The WH1 domain interacts with the PPXXF motif in GRM1,
GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
-!- SIMILARITY: Belongs to the Homer family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB007689; BAA32478.1; -; mRNA.
EMBL; AB007690; BAA32479.1; -; mRNA.
RefSeq; NP_445761.1; NM_053309.1. [O88801-1]
UniGene; Rn.30014; -.
ProteinModelPortal; O88801; -.
SMR; O88801; -.
BioGrid; 248181; 3.
IntAct; O88801; 2.
STRING; 10116.ENSRNOP00000026158; -.
iPTMnet; O88801; -.
PhosphoSitePlus; O88801; -.
PaxDb; O88801; -.
PRIDE; O88801; -.
Ensembl; ENSRNOT00000087785; ENSRNOP00000070858; ENSRNOG00000061450. [O88801-1]
GeneID; 29547; -.
KEGG; rno:29547; -.
UCSC; RGD:620705; rat. [O88801-1]
CTD; 9455; -.
RGD; 620705; Homer2.
eggNOG; ENOG410IGRQ; Eukaryota.
eggNOG; ENOG410XQWT; LUCA.
GeneTree; ENSGT00390000017850; -.
HOGENOM; HOG000006979; -.
HOVERGEN; HBG051918; -.
InParanoid; O88801; -.
KO; K15010; -.
OMA; REKCNDQ; -.
OrthoDB; EOG091G0CQ0; -.
PhylomeDB; O88801; -.
TreeFam; TF325627; -.
Reactome; R-RNO-6794361; Neurexins and neuroligins.
PRO; PR:O88801; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000061450; -.
Genevisible; O88801; RN.
GO; GO:0045177; C:apical part of cell; ISO:RGD.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0032426; C:stereocilium tip; ISS:UniProtKB.
GO; GO:0003779; F:actin binding; ISO:RGD.
GO; GO:0035256; F:G-protein coupled glutamate receptor binding; IPI:UniProtKB.
GO; GO:0030160; F:GKAP/Homer scaffold activity; ISO:RGD.
GO; GO:0035254; F:glutamate receptor binding; IPI:RGD.
GO; GO:0019904; F:protein domain specific binding; IMP:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IPI:RGD.
GO; GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO; GO:0048148; P:behavioral response to cocaine; ISO:RGD.
GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISO:RGD.
GO; GO:0048875; P:chemical homeostasis within a tissue; ISO:RGD.
GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISO:RGD.
GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR000697; WH1/EVH1_dom.
Pfam; PF00568; WH1; 1.
SMART; SM00461; WH1; 1.
PROSITE; PS50229; WH1; 1.
1: Evidence at protein level;
Alternative splicing; Cell junction; Cell membrane; Cell projection;
Coiled coil; Complete proteome; Cytoplasm; Hearing; Membrane;
Postsynaptic cell membrane; Reference proteome; Synapse.
CHAIN 1 354 Homer protein homolog 2.
/FTId=PRO_0000191010.
DOMAIN 1 110 WH1. {ECO:0000255|PROSITE-
ProRule:PRU00410}.
COILED 92 120 {ECO:0000255}.
COILED 160 329 {ECO:0000255}.
VAR_SEQ 130 140 Missing (in isoform 2).
{ECO:0000303|PubMed:9727012}.
/FTId=VSP_009072.
SEQUENCE 354 AA; 40563 MW; 205FA6358F9D198E CRC64;
MGEQPIFTTR AHVFQIDPST KKNWVPASKQ AVTVSYFYDV TRNSYRIISV DGAKVIINST
ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA EKFQEVREAA RLARDKSQEK
IETSSNHSQE SGCETPSSTQ ASSVNGTDDE KASHASPADT HLKSENDKLK IALTQSAANV
KKWEIELQTL RESNARLTTA LQESAASVEQ WKRQFSICRD ENDRLRSKIE ELEEQCGEIN
REKEKNTQLK RRIEELESEV REKEMELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN
LEDKVRSLKT DIEESKYRQR HLKGELKSFL EVLDGKIDDL HDFRRGLSKL GTDN


Related products :

Catalog number Product name Quantity
HOME1_MOUSE ELISA Kit FOR Homer protein homolog 1; organism: Mouse; gene name: Homer1 96T
HOME2_MOUSE ELISA Kit FOR Homer protein homolog 2; organism: Mouse; gene name: Homer2 96T
HOME3_MOUSE ELISA Kit FOR Homer protein homolog 3; organism: Mouse; gene name: Homer3 96T
29-203 HOMER1 is a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.This gene encodes a member of the homer family of dendri 0.05 mg
29-202 HOMER1 is a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function.This gene encodes a member of the homer family of dendri 0.05 mg
HOMEZ HOMER2 Gene homer homolog 2 (Drosophila)
HOMER3 HOMER1 Gene homer homolog 1 (Drosophila)
HOOK1 HOMER3 Gene homer homolog 3 (Drosophila)
SCH-AHP737 RAT ANTI RAT HOMER (aa177_366), Product Type Polyclonal Antibody, Specificity HOMER , Target Species Rat, Host Rat, Format Serum, Isotypes Polyclonal IgG, Applications C, WB, Clone 0.1 ml
AHP737 RAT ANTI RAT HOMER (aa177_366), Product Type Polyclonal Antibody, Specificity HOMER , Target Species Rat, Host Rat, Format Serum, Isotypes Polyclonal IgG, Applications C, WB, Clone 0.1 ml
SCH-AHP736 RAT ANTI RAT HOMER (aa1_186), Product Type Polyclonal Antibody, Specificity HOMER , Target Species Rat, Host Rat, Format Serum, Isotypes Polyclonal IgG, Applications C, WB, Clone 0.1 ml
AHP736 RAT ANTI RAT HOMER (aa1_186), Product Type Polyclonal Antibody, Specificity HOMER , Target Species Rat, Host Rat, Format Serum, Isotypes Polyclonal IgG, Applications C, WB, Clone 0.1 ml
HOME1_MOUSE Mouse ELISA Kit FOR Homer protein homolog 1 96T
SPF30_HUMAN Human ELISA Kit FOR Homer protein homolog 1 96T
orb81165 Human Homer Homolog-1 protein Proteins 5
HOME2_MOUSE Mouse ELISA Kit FOR Homer protein homolog 2 96T
E0631h Human ELISA Kit FOR Homer protein homolog 1 96T
HOME1_BOVIN Bovine ELISA Kit FOR Homer protein homolog 1 96T
CSB-EL010634RA Rat Homer protein homolog 1(HOMER1) ELISA kit 96T
Y050644 Anti_Phospho_HOMER3(Homer protein homolog 3)_(N_terminal) 100ug
CSB-RP030074h Recombinant human Homer protein homolog 1 500ug
CSB-RP030044h Recombinant human Homer protein homolog 1 500ug
CSB-EL010635RA Rat Homer protein homolog 2(HOMER2) ELISA kit 96T
CSB-EL010638RA Rat Homer protein homolog 3(HOMER3) ELISA kit 96T
E15028b Human ELISA Kit FOR Homer protein homolog 2 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur