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HrnA1 Starter unit polyketide synthase type I modules loading, 1-3

 A0A167RND4_9ACTN        Unreviewed;      6334 AA.
A0A167RND4;
06-JUL-2016, integrated into UniProtKB/TrEMBL.
06-JUL-2016, sequence version 1.
25-OCT-2017, entry version 10.
SubName: Full=HrnA1 Starter unit polyketide synthase type I modules loading, 1-3 {ECO:0000313|EMBL:SAI82895.1};
Name=hrnA1 {ECO:0000313|EMBL:SAI82895.1};
Streptomyces sp. CMB-0406.
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
Streptomyces.
NCBI_TaxID=1826667 {ECO:0000313|EMBL:SAI82895.1};
[1] {ECO:0000313|EMBL:SAI82895.1}
NUCLEOTIDE SEQUENCE.
STRAIN=CBM-0406 {ECO:0000313|EMBL:SAI82895.1};
Booth T.J., Alt S., Capon R.J., Wilkinson B.;
"Spontaneous tandem electrocyclisations of the polyene macrolactam
polyketide heronamide C.";
Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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EMBL; LT548273; SAI82895.1; -; Genomic_DNA.
GO; GO:0003824; F:catalytic activity; IEA:InterPro.
GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
GO; GO:0006089; P:lactate metabolic process; IEA:InterPro.
GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
Gene3D; 1.10.1200.10; -; 4.
Gene3D; 3.30.70.250; -; 4.
Gene3D; 3.30.70.610; -; 1.
Gene3D; 3.40.47.10; -; 8.
InterPro; IPR036736; ACP-like_sf.
InterPro; IPR014043; Acyl_transferase.
InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
InterPro; IPR016172; D-lactate_DH_C-sub1.
InterPro; IPR032821; KAsynt_C_assoc.
InterPro; IPR018201; Ketoacyl_synth_AS.
InterPro; IPR014031; Ketoacyl_synth_C.
InterPro; IPR014030; Ketoacyl_synth_N.
InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR020801; PKS_acyl_transferase.
InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
InterPro; IPR020807; PKS_dehydratase.
InterPro; IPR013968; PKS_KR.
InterPro; IPR020806; PKS_PP-bd.
InterPro; IPR009081; PP-bd_ACP.
InterPro; IPR006162; Ppantetheine_attach_site.
InterPro; IPR016039; Thiolase-like.
Pfam; PF00698; Acyl_transf_1; 4.
Pfam; PF16197; KAsynt_C_assoc; 4.
Pfam; PF00109; ketoacyl-synt; 4.
Pfam; PF02801; Ketoacyl-synt_C; 4.
Pfam; PF08659; KR; 3.
Pfam; PF00550; PP-binding; 4.
Pfam; PF14765; PS-DH; 3.
SMART; SM00827; PKS_AT; 4.
SMART; SM00826; PKS_DH; 3.
SMART; SM00825; PKS_KS; 4.
SMART; SM00823; PKS_PP; 4.
SUPFAM; SSF47336; SSF47336; 4.
SUPFAM; SSF51735; SSF51735; 6.
SUPFAM; SSF52151; SSF52151; 8.
SUPFAM; SSF53901; SSF53901; 4.
SUPFAM; SSF55048; SSF55048; 4.
PROSITE; PS50075; ACP_DOMAIN; 4.
PROSITE; PS00606; B_KETOACYL_SYNTHASE; 3.
PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
4: Predicted;
DOMAIN 870 940 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 2628 2698 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 4414 4484 Carrier. {ECO:0000259|PROSITE:PS50075}.
DOMAIN 6178 6248 Carrier. {ECO:0000259|PROSITE:PS50075}.
MOD_RES 4449 4449 O-(pantetheine 4'-phosphoryl)serine.
{ECO:0000256|PROSITE-ProRule:PRU00258}.
SEQUENCE 6334 AA; 667087 MW; 170A8BD8DC29D98C CRC64;
MLPDSPERHR AALRHGGFLD RVDQFDAAFF GISPREAVAI DPQQRLFAEL AWEALEDAGI
VPETLRSTAT AVIVGAIAGD YAALAHRGGA ITQHSLPGLN RGVIANRVSY ALGLNGPSMA
VDSAQSSSLV AVHLAVESLR KGEATLALAG GVALNFAPES AEVAGMFGGL SPDGRCFTFD
ARANGYVRGE GGGVVVLKRL ADAVRDGDTV YGVIRGSAVN NDGSTDGLTV PSAEAQATVL
RQACEDAGVD PAEVRYVELH GTGTPTGDPL EAAGIGATYG SARPAGEPVL VGSAKTNVGH
LEGAAGIVGL IKTALSIRHR EIPASLNYET PNPRIDPDAL NLRVQTASGP WPDAPLLAGV
SSFGVGGTNC HVVLAEAPER AVPEAAQRGD EPELELAPWL VSGRTEAALR AQAGRLLERA
TGDADAFDIG RSLAGTRTHF EHRAVALGLD HDAQLEALRS GAEVPGLVTG VTGEHGKVAL
VFPGQGSQWE GMARELMRTS PVFRASIEAC HEALAPYVDW SLLDTLTAES GAALDRADVV
QPVLFAVMVS LARVWESLGV RPDAVIGHSQ GEIAAAHIAG ALDLADAARI VALRSQTIMT
LAGTGAMASV PLAADRVAEY IEPFGDGLSI AVVNGPTTTV VAGTPDAVAE LLARCESDGI
RAKAVSAVDF ASHSPHMDAI KDRLLDQFAG VTPRSCDIAF YSTVTASAVD TAGLDADYWF
SNLRRPVLFE STLRAMAEDG FGTFVESSPH PVLTVGLRAT LPDAVVVDSL RRNETPWPQL
LTSLAELHVR GLPVDWSAVF AGREPGRVAL PTYAFQRESY WPDVSTAFEP GTRSAGQLPE
PAREETPAAA GSSWSRRIAG LPADERTRVA LELVRVRTAI VLGHLSTDTV EVGQAFRELG
MDSTMAVQLR QNLVDVTGLA LPETVVFDHP SPSRLARRLI ELALGDDTSS AASVLSRSGA
VLDADDPIVI VGMACRYPGG AATPDELWRL VDDGVSAISG FPTDRGWDLE ALYDPEPGVR
GKTYTRHGGF LDEAAEFDTE FFGISPREAT AMDPQQRVLL QVTWEALERA GIDPDGLQGS
STGVFVGAMS QEYGPRLHEG DDGLGGYLLT GNTASVVSGR ISYTFGLEGP AVTVDTACSS
SLVAMHQAAQ ALRAGDCSLA LAGGVAVMAT PGMFVEFGQQ RGLAPDGRCK SFAGAADGTI
WAEGAGMVLM ERLSDAKANG HTVLAVVRGS AVNQDGASNG LTAPNGPSQQ RVINAALAGA
GLTGDQVDAV EAHGTGTPLG DPIEAQALLA TYGQNREEPL WLGSLKSNIG HTQAAAGIGG
VIKMIQAMRH GTLPRTINVD EPSPHIDWTS GNVQLLTEAR AWPETDHPRR AAVSSFGISG
TNAHLIIEQP PVPPEPAEDE QERDAPGAGL VPWFLSAKTE QSLRDQARQL LDHVTAQPDL
HPAHIGQALT GTRARFQHRA VVIGEGRDEL LAGLRSLSNG ESSREVVTGT AREGTTAFLF
TGQGSQRAGM GRELYDTYPV FRDTFDEVCA TLDRHLNAEV PVKDVVFADD PELLNQTRYT
QSALFAIETA LYRLVESFGI TPHHLAGHSI GEITAAHVAG IFTLDDASRL VAARGSLMQA
LPGNGAMISL RATEEQVLPL LEGHEHHVTI AAVNGPNSVV ISGDEKAATR IAGSLAKTGI
KTKRLTVSHA FHSPHMDPML AEFERVAADL TYHTPMIPVV SAVTGELADH RVTTPQYWVQ
HVRDAVRFAD TITTLDQLGT RHYLELGPDP VLTTLVNETL TKSRNSTSPV AVLRKGHAEA
TTLLTALATA HAAGAHANLT THLPSADSHP DLPTYPFQRQ RYWLTATAAT GDVSSAGLTA
TGHPVLTTAA ELPDPGGLLL TGRVNASAPP WAADHAVFGT PVMPGVAFVD MLLHAAALVG
RPRIEELTHH VFLALPEHGA LQLRVVVRPA DDSGRRTFAV HSRPEDAPLG ADWTCHATGA
LGTAPAVPPA LPPADAVWPP ASAEALDTDG FYRRIAEAGF GYAGVFQGLG AAWEDGDTLY
AEVALPAGTA PGSYGVHPGL LDSALHPIAL ASTRTDGTLL VPFSWSGVAL HANGARALRV
ELVRSTPETV ALTVTDPSGA PVLTVDSLAM RGVSSEQLEA ARPDRDGALH EVAWRAVPAP
PRAAARPDGA GWAVVGDTRD PRVAAALAAL GSAADSYPDA EALRASLRAG AARPSTVVAR
FATGGADPVE AAHAQTHEAL DLLQAVLADG APDSRLVILT ENARSTGTGD ASADLAGAAV
WGLIRSSQSE HPDRFTLIDV DGSRASDEAI VAALSTGERQ LALREGRFFV PRLARLTPGA
IPATFDARRT VLITGGTGAL GSILARHLVT RHGVRKLLLT SRSGRTDSAL TAELAGLGAE
VTVAACDAAD RQSLEALLAG LPDEHPLGAV VHCAGVLDDG VVTELTPDRL DAVLRPKVDG
AWNLHELTRD LDLDAFVLFS SVVGVLGSPG QANYAAANSF LDQLAEHRRT AGLPATSLAW
GLWEAGMADT LDEQDRARMN RGGLAPMPTE RALGLFDSAL ATARAVLVPA GVDVSGARSQ
RASMLSPLLA ELLPAQAPPA ERGNEAVDES SLRQQLAGRS EDAQRELLLE VLRKHVAAVL
GHSSPLVIDP ESSFKDLGFD SLAGIELLMV LGESLGLHLP STMLFDHPTP EALITHLRDE
LVDDEALPVD AVETAVVPVV PSDDDDPIAV VGMGCRYPGG ATTPDELWRL VTEGVDAIGS
FPDNRGWDLE ELFDPDPDVR GRTYARTGGF LYDADRFDAE FFGISPREAL ALDPQQRLLL
ETTWETFENA GIRPDALRGK PVGVFAGVVT QEYGSLVHKG SEPVDGFLLT GTTASVASGR
VAYTLGLEGP AVTVDTACSS SLVAMHLACQ SLRNGESTMA LAGGATVMAN PGMFLEFSRQ
RGLAPDGRCK SFAGAADGTI WAEGAGMVLL ERLSDAKANG HTVLAVIRGS AVNQDGASNG
LTAPNGPSQQ RVIKAALAGA GLTADEVDAV EAHGTGTPLG DPIEAQALLA TYGQNREEPL
WLGSLKSNIG HAQAAAGIGG VIKMIQAMRH GTLPRTLHVD EPSPHIDWTS GNVQLLTEER
DWPETGHPRR SAVSSFGISG TNAHVILEQA PVAPESAEDD QEQGGPEAAL IPWLLSAKTE
QALRDQAQQL RTYLELNPEV RPDRVAHALA TTRAQFPYRA VVFGDKHGAF DRALGALTLG
EPSPALVRGT PHPGKTAFLF TGQGAQRPGM GKELYETYSV FRETFDEVCT TLDRHLNAEV
PVKDVVFADD PELLNQTRYT QSALFAIETA LYRLVESFGV TPQYLAGHSI GEIAAAHVAG
IFSLDDACRL VAARGSLMQA LPANGAMISL RATEGQIVPL LEGHEDEVTI AAVNGPSSIV
ISGDEDAATR IAETLAETGV KTRRLTVSHA FHSPHMEPML DEFELVAGEL IYHTPTIPIV
SALSGELADH YITTPQYWVQ HVRDAVRFAD TITTLDRLGT RHYLELGPDP VLTAMAQDSV
PDDVDTVHVA TLHRDRDENQ SFLTALAAAH ANGTQVRWAP VIGESATPAP GLPTYPFQRQ
HYWLEPAKPT SGADGLGLTA TSHPVLTTLA ELPDGGGHLF TGRVSGTDPD WVAEHIIFGT
MIVPGVAFVD LLLHAARHVD CEHIEELTHH VFLAVPERAA LQLRLLVEPA DNSGHRSFAF
YSRPEDVPVE TDWTLHATGV LGAERREVPA GADSLRNEVW PPEITDTMDE MDVAEFYRRV
TDGGFGYGPL FRGLKKAWQD GDTTYAEVSL PAGSDPGDYG IHPGLLDSAL QPAALIMGET
EADDSIRVPF SWAGVSLHAT GASSLRIRHT WTTPDTASLV IADQTGTPVM TIDSLAMRTV
GADQLAATRA ADAGELYKVD WTDVQAVEDK TQSAGAKWAV VADPGNAQVA AALSPLGAAV
EVAPDAITLP TTPGDDTTRP DVVFTWCVSE PGADPAETAR SFTHRVLGLV QTVLADDRPD
SRLVVLTRGA MSTGTGGGTD LAGAAVWGLI RTAQTEHPDR FTLIDLDGSD SSLRALSAAL
TTDEPQLAVR DGRLLAPRLA RVGASSTDSG SGSDATSDSA STASTAPFDP DRTVLITGGT
GALGTLLARH LVTEHGVRKL LLTSRRGRTA DSTITEELAE LGAEVTIAAC DTADRESLET
LLASLPDEHP LGAVVHCAGT LDDGIVTALT PERFDGVLRP KVDGAWNLHE LTRDLDLTAF
VMFSSVVGVL GSPGQSNYAA ANVFLDELAE HRRSAGLPAK SLAWGLWESG MADTLDEQDQ
ARMNRGGLLP MPADQALGHF DAALEADQVV VVPAKLDLAG LRARAATTPV APVFRGLVRT
PLRSAAQSAG AGAEVGALGQ AIAGRPEAEQ DKIILDFLRN HVATVLGHGS PNSIDPVHSF
KELGFDSLSS VELRNSLNKA SGMRLPSTLL FDYPTPTVLA GYIRSQLVGS GQAEAGTQVA
RRTTRSASSR SDAADPIVIV GMGCRFPGAD TPEALWQLVV DERDAVGAFP DNRGWDIENL
FDADPDVRGK SYASEGGFLY DADRFDPEFF GISPREALAL DPQQRLLLET TWETFENAGI
RPDALRGKPV GVFAGVAAAE YVSLTHQGAE PVEGYLLTGT TSSVASGRIS YTLGLEGPAV
TVDTACSSSL VAMHLACQSL RNGESTMALA GGATIMANPG MFMEFSRQRG LAPDSRAKSY
AGAADGTIWA EGAGMVLLER LSDAKANGHT VLAVIRGSAV NQDGASNGLT APNGPSQQRV
INAALAGAGL SPDQVDAVEG HGTGTPLGDP IEAQALLATY GQNREEPLWL GSLKSNIGHA
QAAAGIGGVI KMIQAMRHGT LPRTLHVDEP SPQIDWESGN VQLLTEARAW PETDHPRRSA
VSSFGISGTN AHLILEEAPT ATHPEPVRDT EPTVGTVPWF LSAKTEQALR DQARQLSAYL
ESDTEARPDQ VAHALASTRS QFQHRAVVVG EGRDELLAGL RSLSDGETSR TVVTGTARPG
ATAFLFTGQG AQRPGMGKEL YETYPVFREA FDEVCAKLDA HLDAEVPVRD VVFADNPELL
NQTRYTQSAL FAIETALYRL VESFGLTPHH LAGHSIGEIT AAHVAGIFTL DDASRLVAAR
GSLMQALPGN GAMISLRATE EQVLPLLEGH EHHVTIAAVN GPNSVVISGD EEAATRIAET
LAETGVKTRR LTVSHAFHSP HMDPMLAEFE RVASDLTYHT PTIPIVSAVT GEVADHRVAT
AQYWVQHVRD AVRFADTIRT LDELGTRHYL ELGPDPVLTT LANETLGATS GTHTATPTAV
LRKGHSEAGT LLIALATAHT AGAPADLTAH LPARQSHPNL PTYPFQRQRY WLDQAGPAAK
VQNGSGHPLL TAAIPLPDGE GAVFTGRVSL KAQPWLRDHV VHGTVVLPGV AFVDLLLHAG
GYVDCDQIEE LTHHAFLAVP EQGGRELRVT VGAADEGGRR PFSLYSAPES EDAEESAEWT
RHASGFLTGA APEPDFDLTV WPPAEGEAVE MEEFYRGFIG RGYDYGPLFQ GFKAGWRVGE
TLYAEIALPE GTDPEAYGIH PALLDSALHP LMLFWYGSDA VRLPFSWSGV ALHAFGPSRL
RVRLTRSERD LMSLAVADPT GAPVLTITGL SMREVASDQV AAARAQQSNA LYEMGWSPLA
APASADAGRW AGIGLADLTA ALRGAGTDVV DHSTLATLSG PASNGAKPPR IVLAGPGRFD
GDDLAAHTHT SVDELVKLIR DFVSDDALSD SRLVVVTRNA VATADGEQVP DPAGTAVWGL
MRTAGSEYPD RFVIVDIDGS DATLAALPAA LATGEPQLAI REGESRVPRL VHATLPTQED
GGETEATGAG FAPEGTVLIT GGTGTLGGLL ARHLVERHGV RHLLLTSRRG PAADGATELT
AELKALGAEV SVAACDTAVA EEAAGLLKSI PDAHPLTGVF HTAGVLDDAA LSSLTPERLS
AVLRPKVDGA YHLHQLTESM DLAAFVLFSS AAGAIGNPGQ ANYAAANTFL DGLASHRRGR
GLPALSLAWG LWAQTSELTA GLDPVGRARL DRGGIGAMPT AQALALLDVA LASDRTLLVP
AKLNLARLGD GDAPVPPVLH GLVRPRGRRA AAQGGATAPN ALRQRLASQD EAAQLDILLS
YIHGQVAAVL GHGSPDAIDP DSGFLDMGLD SLTTVEFRNN LNQATGLRLP PTTLFDYPTP
VQLATMLRAE LAPEGAERAP DEVPQALVAE LDRLEGSLGT VAPGARTAVV ARMQALLQKL
DGLEDAERQG TNVAIESATD DDLFDFIDNE LGLS


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