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Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein)

 HPLN1_MOUSE             Reviewed;         356 AA.
Q9QUP5; Q9D1G9; Q9Z1X7;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 145.
RecName: Full=Hyaluronan and proteoglycan link protein 1;
AltName: Full=Cartilage-linking protein 1;
Short=Cartilage-link protein;
AltName: Full=Proteoglycan link protein;
Flags: Precursor;
Name=Hapln1; Synonyms=Crtl1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
STRAIN=129/Sv;
PubMed=10640815;
Deak F., Mates L., Krysan K., Liu Z., Szabo P.E., Mann J.R.,
Beier D.R., Kiss I.;
"Characterization and chromosomal location of the mouse link protein
gene (Crtl1).";
Cytogenet. Cell Genet. 87:75-79(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=BALB/cJ;
PubMed=12732630; DOI=10.1074/jbc.M303329200;
Czipri M., Otto J.M., Cs-Szabo G., Kamath R.V., Vermes C.,
Firneisz G., Kolman K.J., Watanabe H., Li Y., Roughley P.J.,
Yamada Y., Olsen B.R., Glant T.T.;
"Genetic rescue of chondrodysplasia and the perinatal lethal effect of
cartilage link protein deficiency.";
J. Biol. Chem. 278:39214-39223(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo, and Embryonic head;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Stabilizes the aggregates of proteoglycan monomers with
hyaluronic acid in the extracellular cartilage matrix.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix.
-!- TISSUE SPECIFICITY: Ubiquitously expressed.
{ECO:0000269|PubMed:12732630}.
-!- SIMILARITY: Belongs to the HAPLN family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF137278; AAF24166.1; -; Genomic_DNA.
EMBL; AF137275; AAF24166.1; JOINED; Genomic_DNA.
EMBL; AF137276; AAF24166.1; JOINED; Genomic_DNA.
EMBL; AF137277; AAF24166.1; JOINED; Genomic_DNA.
EMBL; AF139572; AAF24977.1; -; mRNA.
EMBL; AF098460; AAD12253.1; -; mRNA.
EMBL; AK032750; BAC28007.1; -; mRNA.
EMBL; AK048107; BAC33244.1; -; mRNA.
EMBL; BC066853; AAH66853.1; -; mRNA.
CCDS; CCDS26671.1; -.
RefSeq; NP_038528.3; NM_013500.4.
UniGene; Mm.266790; -.
ProteinModelPortal; Q9QUP5; -.
SMR; Q9QUP5; -.
BioGrid; 198904; 1.
IntAct; Q9QUP5; 2.
MINT; MINT-4097928; -.
STRING; 10090.ENSMUSP00000022108; -.
iPTMnet; Q9QUP5; -.
PhosphoSitePlus; Q9QUP5; -.
MaxQB; Q9QUP5; -.
PaxDb; Q9QUP5; -.
PeptideAtlas; Q9QUP5; -.
PRIDE; Q9QUP5; -.
Ensembl; ENSMUST00000022108; ENSMUSP00000022108; ENSMUSG00000021613.
GeneID; 12950; -.
KEGG; mmu:12950; -.
UCSC; uc007rjf.2; mouse.
CTD; 1404; -.
MGI; MGI:1337006; Hapln1.
eggNOG; ENOG410IF28; Eukaryota.
eggNOG; ENOG410XRS8; LUCA.
GeneTree; ENSGT00760000119025; -.
HOGENOM; HOG000234353; -.
HOVERGEN; HBG051922; -.
InParanoid; Q9QUP5; -.
KO; K06848; -.
OMA; WRSGLDW; -.
OrthoDB; EOG091G09EL; -.
PhylomeDB; Q9QUP5; -.
TreeFam; TF332134; -.
PRO; PR:Q9QUP5; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000021613; -.
CleanEx; MM_HAPLN1; -.
Genevisible; Q9QUP5; MM.
GO; GO:0031012; C:extracellular matrix; ISO:MGI.
GO; GO:0005578; C:proteinaceous extracellular matrix; IDA:MGI.
GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
GO; GO:0005540; F:hyaluronic acid binding; IBA:GO_Central.
GO; GO:0007155; P:cell adhesion; IEA:InterPro.
GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
GO; GO:0001501; P:skeletal system development; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 3.10.100.10; -; 2.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
InterPro; IPR000538; Link_dom.
Pfam; PF07686; V-set; 1.
Pfam; PF00193; Xlink; 2.
PRINTS; PR01265; LINKMODULE.
SMART; SM00409; IG; 1.
SMART; SM00406; IGv; 1.
SMART; SM00445; LINK; 2.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF56436; SSF56436; 2.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS01241; LINK_1; 2.
PROSITE; PS50963; LINK_2; 2.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein;
Hyaluronic acid; Immunoglobulin domain; Reference proteome; Repeat;
Secreted.
PROPEP 1 9 {ECO:0000250}.
/FTId=PRO_0000013179.
CHAIN 10 356 Hyaluronan and proteoglycan link protein
1.
/FTId=PRO_0000013180.
DOMAIN 40 154 Ig-like V-type.
DOMAIN 161 256 Link 1. {ECO:0000255|PROSITE-
ProRule:PRU00323}.
DOMAIN 261 353 Link 2. {ECO:0000255|PROSITE-
ProRule:PRU00323}.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 63 141 {ECO:0000250}.
DISULFID 183 254 {ECO:0000250}.
DISULFID 207 228 {ECO:0000250}.
DISULFID 281 351 {ECO:0000250}.
DISULFID 306 327 {ECO:0000250}.
CONFLICT 18 18 Missing (in Ref. 2; AAD12253).
{ECO:0000305}.
CONFLICT 35 35 Q -> H (in Ref. 4; AAH66853).
{ECO:0000305}.
SEQUENCE 356 AA; 40478 MW; 3FB4B8F30E28C9F2 CRC64;
MRSLLLLVLI SVCWADHHLS DSYTPPDQDR VIHIQAENGP RLLVEAEQAK VFSHRGGNVT
LPCKFYRDPT AFGSGIHKIR IKWTKLTSDY LREVDVFVSM GYHKKTYGGY QGRVFLKGGS
DNDASLVITD LTLEDYGRYK CEVIEGLEDD TAVVALELQG VVFPYFPRLG RYNLNFHEAR
QACLDQDAVI ASFDQLYDAW RGGLDWCNAG WLSDGSVQYP ITKPREPCGG QNTVPGVRNY
GFWDKDKSRY DVFCFTSNFN GRFYYLIHPT KLTYDEAVQA CLNDGAQIAK VGQIFAAWKL
LGYDRCDAGW LADGSVRYPI SRPRRRCSPT EAAVRFVGFP DKKHKLYGVY CFRAYN


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