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Hydroxyacyl-CoA dehydrogenase (Hydroxyacyl-Coenzyme A dehydrogenase)

 Q6DI22_DANRE            Unreviewed;       309 AA.
Q6DI22;
16-AUG-2004, integrated into UniProtKB/TrEMBL.
16-AUG-2004, sequence version 1.
10-OCT-2018, entry version 115.
SubName: Full=Hydroxyacyl-CoA dehydrogenase {ECO:0000313|Ensembl:ENSDARP00000050602};
SubName: Full=Hydroxyacyl-Coenzyme A dehydrogenase {ECO:0000313|EMBL:AAH75768.1};
Name=hadh {ECO:0000313|EMBL:AAH75768.1,
ECO:0000313|Ensembl:ENSDARP00000050602,
ECO:0000313|ZFIN:ZDB-GENE-040801-261};
Synonyms=hadhsc {ECO:0000313|ZFIN:ZDB-GENE-040801-261};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH75768.1};
[1] {ECO:0000313|EMBL:AAH75768.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo {ECO:0000313|EMBL:AAH75768.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSDARP00000050602}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000050602};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|Ensembl:ENSDARP00000050602, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000050602,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
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EMBL; BX572104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC075768; AAH75768.1; -; mRNA.
RefSeq; NP_001003515.1; NM_001003515.1.
UniGene; Dr.34131; -.
STRING; 7955.ENSDARP00000050602; -.
Ensembl; ENSDART00000050603; ENSDARP00000050602; ENSDARG00000030765.
GeneID; 445121; -.
KEGG; dre:445121; -.
CTD; 3033; -.
ZFIN; ZDB-GENE-040801-261; hadh.
eggNOG; KOG2304; Eukaryota.
eggNOG; COG1250; LUCA.
GeneTree; ENSGT00880000137923; -.
HOGENOM; HOG000141498; -.
HOVERGEN; HBG000832; -.
KO; K00022; -.
OMA; MAHPMGP; -.
OrthoDB; EOG091G089P; -.
TreeFam; TF300886; -.
Reactome; R-DRE-77310; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
Reactome; R-DRE-77346; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
Reactome; R-DRE-77348; Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
Reactome; R-DRE-77350; Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
Reactome; R-DRE-77352; Beta oxidation of butanoyl-CoA to acetyl-CoA.
Proteomes; UP000000437; Chromosome 1.
Bgee; ENSDARG00000030765; Expressed in 29 organ(s), highest expression level in cardiac ventricle.
GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
Gene3D; 1.10.1040.10; -; 1.
InterPro; IPR022694; 3-OHacyl-CoA_DH.
InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
InterPro; IPR006108; 3HC_DH_C.
InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
InterPro; IPR013328; 6PGD_dom2.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF00725; 3HCDH; 1.
Pfam; PF02737; 3HCDH_N; 1.
PIRSF; PIRSF000105; HCDH; 1.
SUPFAM; SSF48179; SSF48179; 1.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00067; 3HCDH; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000000437};
NAD {ECO:0000256|PIRSR:PIRSR000105-2};
Proteomics identification {ECO:0000213|PeptideAtlas:Q6DI22};
Reference proteome {ECO:0000313|Proteomes:UP000000437}.
DOMAIN 24 209 3HCDH_N. {ECO:0000259|Pfam:PF02737}.
DOMAIN 211 307 3HCDH. {ECO:0000259|Pfam:PF00725}.
NP_BIND 29 34 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 52 52 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 68 68 Coenzyme A.
{ECO:0000256|PIRSR:PIRSR000105-3}.
BINDING 75 75 Coenzyme A.
{ECO:0000256|PIRSR:PIRSR000105-3}.
BINDING 117 117 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 122 122 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 144 144 Coenzyme A.
{ECO:0000256|PIRSR:PIRSR000105-3}.
BINDING 144 144 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 168 168 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 300 300 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
SITE 165 165 Important for catalytic activity.
{ECO:0000256|PIRSR:PIRSR000105-1}.
SEQUENCE 309 AA; 33336 MW; 893A07AB0778890B CRC64;
MAFVTRQFSR SFSSSQALHH TIKHVTVIGG GLMGAGIAQV AASTGHSVVL VDTSADILNK
SAKGIENSLK RVAKKKFAEK PEDGEAFVQK VLKNVSTSTD AASVVHGTDL VVEAIVENLK
VKQDLFGALD KVAPEHTIFA SNTSSLPIAD IASCTARLDR FGGLHFFNPV PMMKLVEVIK
TPATSQQTFD ALLEFSKALG KHPVSCKDTP GFIVNRLLVP YMLEAVRLHE RGHGSKEDID
VAMKLGAGYP MGPFELLDYV GLDTSKFIID GWHAKDPDNP LFAPSPLLNK LVSEGKLGKK
TGEGFYKHK


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