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Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

 A0A0A0MSE2_HUMAN        Unreviewed;       317 AA.
A0A0A0MSE2;
07-JAN-2015, integrated into UniProtKB/TrEMBL.
07-JUN-2017, sequence version 2.
12-SEP-2018, entry version 29.
SubName: Full=Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial {ECO:0000313|Ensembl:ENSP00000385638};
Name=HADH {ECO:0000313|Ensembl:ENSP00000385638};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385638, ECO:0000313|Proteomes:UP000005640};
[1] {ECO:0000313|Ensembl:ENSP00000385638, ECO:0000313|Proteomes:UP000005640}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[2] {ECO:0000213|PubMed:19608861}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19608861; DOI=10.1126/science.1175371;
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
Walther T.C., Olsen J.V., Mann M.;
"Lysine acetylation targets protein complexes and co-regulates major
cellular functions.";
Science 325:834-840(2009).
[3] {ECO:0000213|PubMed:21269460}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[4] {ECO:0000213|PubMed:24275569}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[5] {ECO:0000313|Ensembl:ENSP00000385638}
IDENTIFICATION.
Ensembl;
Submitted (NOV-2014) to UniProtKB.
[6] {ECO:0000213|PubMed:25944712}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
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EMBL; AC114733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC118062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; A0A0A0MSE2; -.
SMR; A0A0A0MSE2; -.
STRING; 9606.ENSP00000385638; -.
EPD; A0A0A0MSE2; -.
PaxDb; A0A0A0MSE2; -.
PeptideAtlas; A0A0A0MSE2; -.
PRIDE; A0A0A0MSE2; -.
Ensembl; ENST00000403312; ENSP00000385638; ENSG00000138796.
UCSC; uc062ywf.1; human.
EuPathDB; HostDB:ENSG00000138796.15; -.
HGNC; HGNC:4799; HADH.
OpenTargets; ENSG00000138796; -.
eggNOG; KOG2304; Eukaryota.
eggNOG; COG1250; LUCA.
GeneTree; ENSGT00880000137923; -.
OrthoDB; EOG091G089P; -.
ChiTaRS; HADH; human.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000138796; Expressed in 233 organ(s), highest expression level in parietal pleura.
ExpressionAtlas; A0A0A0MSE2; baseline and differential.
GO; GO:0005739; C:mitochondrion; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
Gene3D; 1.10.1040.10; -; 1.
InterPro; IPR022694; 3-OHacyl-CoA_DH.
InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
InterPro; IPR006108; 3HC_DH_C.
InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
InterPro; IPR013328; 6PGD_dom2.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF00725; 3HCDH; 1.
Pfam; PF02737; 3HCDH_N; 1.
PIRSF; PIRSF000105; HCDH; 1.
SUPFAM; SSF48179; SSF48179; 1.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00067; 3HCDH; 1.
1: Evidence at protein level;
Complete proteome {ECO:0000313|Proteomes:UP000005640};
NAD {ECO:0000256|PIRSR:PIRSR000105-2};
Proteomics identification {ECO:0000213|EPD:A0A0A0MSE2,
ECO:0000213|MaxQB:A0A0A0MSE2, ECO:0000213|PeptideAtlas:A0A0A0MSE2};
Reference proteome {ECO:0000313|Proteomes:UP000005640}.
DOMAIN 29 214 3HCDH_N. {ECO:0000259|Pfam:PF02737}.
DOMAIN 216 316 3HCDH. {ECO:0000259|Pfam:PF00725}.
NP_BIND 34 39 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 57 57 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 73 73 Coenzyme A.
{ECO:0000256|PIRSR:PIRSR000105-3}.
BINDING 80 80 Coenzyme A.
{ECO:0000256|PIRSR:PIRSR000105-3}.
BINDING 122 122 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 127 127 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 149 149 Coenzyme A.
{ECO:0000256|PIRSR:PIRSR000105-3}.
BINDING 149 149 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 173 173 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
BINDING 308 308 NAD. {ECO:0000256|PIRSR:PIRSR000105-2}.
SITE 170 170 Important for catalytic activity.
{ECO:0000256|PIRSR:PIRSR000105-1}.
SEQUENCE 317 AA; 34595 MW; B498E385EB8DF48D CRC64;
MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE
DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI ATSTDAASVV HSTDLVVEAI
VENLKVKNEL FKRLDKFAAE HTIFASNTSS LQITSIANAT TRQDRFAGLH FFNPVPVMKL
VEVIKTPMTS QKTFESLVDF SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERVSDG
DASKEDIDTA MKLGAGYPMG PFELLDYVGL DTTKFIVDGW HEMDAENPLH QPSPSLNKLV
AENKFGKKTG EGFYKYK


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