Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Hydroxyphenylpyruvate reductase (HPPR) (EC 1.1.1.237)

 HPPR_PLESU              Reviewed;         313 AA.
Q65CJ7;
29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
24-MAY-2005, sequence version 2.
25-OCT-2017, entry version 66.
RecName: Full=Hydroxyphenylpyruvate reductase;
Short=HPPR;
EC=1.1.1.237;
Name=HPPR;
Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae;
Ocimeae; Solenostemon.
NCBI_TaxID=4142;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 37-65 AND 147-162,
FUNCTION, AND CATALYTIC ACTIVITY.
PubMed=15284489; DOI=10.1023/B:PLAN.0000036367.03056.b2;
Kim K.H., Janiak V., Petersen M.;
"Purification, cloning and functional expression of
hydroxyphenylpyruvate reductase involved in rosmarinic acid
biosynthesis in cell cultures of Coleus blumei.";
Plant Mol. Biol. 54:311-323(2004).
[2]
X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH NADP.
PubMed=20445235; DOI=10.1107/S0907444910006360;
Janiak V., Petersen M., Zentgraf M., Klebe G., Heine A.;
"Structure and substrate docking of a hydroxy(phenyl)pyruvate
reductase from the higher plant Coleus blumei Benth.";
Acta Crystallogr. D 66:593-603(2010).
-!- FUNCTION: Catalyzes the NAD(P)H-dependent reduction of 4-
hydroxyphenylpyruvate to 4-hydroxyphenyllactate and 3,4-
dihydroxyphenylpyruvate to 3,4-dihydroxyphenyllactate in the
biosynthesis of rosmarinic acid. Rosmarinic acid is an ester of
caffeic acid and 3,4-dihydroxyphenyllactic acid. NADP is the
preferred substrate. {ECO:0000269|PubMed:15284489}.
-!- CATALYTIC ACTIVITY: 3-(4-hydroxyphenyl)lactate + NAD(+) = 3-(4-
hydroxyphenyl)pyruvate + NADH. {ECO:0000269|PubMed:15284489}.
-!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
dehydrogenase family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AJ507733; CAD47810.2; -; mRNA.
PDB; 3BA1; X-ray; 1.47 A; A=1-313.
PDB; 3BAZ; X-ray; 2.20 A; A=1-313.
PDBsum; 3BA1; -.
PDBsum; 3BAZ; -.
ProteinModelPortal; Q65CJ7; -.
SMR; Q65CJ7; -.
BRENDA; 1.1.1.237; 1561.
EvolutionaryTrace; Q65CJ7; -.
GO; GO:0047995; F:hydroxyphenylpyruvate reductase activity; IDA:UniProtKB.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0102742; F:R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity; IEA:UniProtKB-EC.
GO; GO:0055114; P:oxidation-reduction process; IDA:UniProtKB.
InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
InterPro; IPR029752; D-isomer_DH_CS1.
InterPro; IPR006140; D-isomer_DH_NAD-bd.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF00389; 2-Hacid_dh; 1.
Pfam; PF02826; 2-Hacid_dh_C; 1.
SUPFAM; SSF51735; SSF51735; 1.
PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
1: Evidence at protein level;
3D-structure; Direct protein sequencing; NAD; NADP;
Nucleotide-binding; Oxidoreductase; Pyruvate.
CHAIN 1 313 Hydroxyphenylpyruvate reductase.
/FTId=PRO_0000422581.
NP_BIND 152 155 NADP. {ECO:0000269|PubMed:20445235}.
NP_BIND 174 176 NADP. {ECO:0000269|PubMed:20445235}.
ACT_SITE 232 232 {ECO:0000250}.
ACT_SITE 261 261 {ECO:0000250}.
ACT_SITE 279 279 Proton donor. {ECO:0000250}.
BINDING 230 230 NADP; via carbonyl oxygen.
{ECO:0000269|PubMed:20445235}.
BINDING 256 256 NADP. {ECO:0000269|PubMed:20445235}.
STRAND 5 8 {ECO:0000244|PDB:3BA1}.
HELIX 14 23 {ECO:0000244|PDB:3BA1}.
STRAND 24 28 {ECO:0000244|PDB:3BA1}.
HELIX 29 31 {ECO:0000244|PDB:3BA1}.
HELIX 35 42 {ECO:0000244|PDB:3BA1}.
TURN 43 45 {ECO:0000244|PDB:3BA1}.
STRAND 46 51 {ECO:0000244|PDB:3BA1}.
STRAND 53 55 {ECO:0000244|PDB:3BA1}.
HELIX 59 64 {ECO:0000244|PDB:3BA1}.
STRAND 70 76 {ECO:0000244|PDB:3BA1}.
HELIX 83 89 {ECO:0000244|PDB:3BA1}.
STRAND 92 94 {ECO:0000244|PDB:3BA1}.
HELIX 101 116 {ECO:0000244|PDB:3BA1}.
HELIX 119 127 {ECO:0000244|PDB:3BA1}.
HELIX 130 133 {ECO:0000244|PDB:3BA1}.
STRAND 147 150 {ECO:0000244|PDB:3BA1}.
HELIX 154 164 {ECO:0000244|PDB:3BA1}.
TURN 165 167 {ECO:0000244|PDB:3BA1}.
STRAND 170 173 {ECO:0000244|PDB:3BA1}.
STRAND 183 187 {ECO:0000244|PDB:3BA1}.
HELIX 189 194 {ECO:0000244|PDB:3BA1}.
STRAND 197 201 {ECO:0000244|PDB:3BA1}.
HELIX 207 209 {ECO:0000244|PDB:3BA1}.
HELIX 215 221 {ECO:0000244|PDB:3BA1}.
STRAND 226 229 {ECO:0000244|PDB:3BA1}.
HELIX 233 235 {ECO:0000244|PDB:3BA1}.
HELIX 238 246 {ECO:0000244|PDB:3BA1}.
STRAND 252 256 {ECO:0000244|PDB:3BA1}.
TURN 259 262 {ECO:0000244|PDB:3BA1}.
HELIX 266 270 {ECO:0000244|PDB:3BA1}.
STRAND 274 276 {ECO:0000244|PDB:3BA1}.
HELIX 285 303 {ECO:0000244|PDB:3BA1}.
STRAND 309 311 {ECO:0000244|PDB:3BA1}.
SEQUENCE 313 AA; 34128 MW; 191F25E7E3226586 CRC64;
MEAIGVLMMC PMSTYLEQEL DKRFKLFRYW TQPAQRDFLA LQAESIRAVV GNSNAGADAE
LIDALPKLEI VSSFSVGLDK VDLIKCEEKG VRVTNTPDVL TDDVADLAIG LILAVLRRIC
ECDKYVRRGA WKFGDFKLTT KFSGKRVGII GLGRIGLAVA ERAEAFDCPI SYFSRSKKPN
TNYTYYGSVV ELASNSDILV VACPLTPETT HIINREVIDA LGPKGVLINI GRGPHVDEPE
LVSALVEGRL GGAGLDVFER EPEVPEKLFG LENVVLLPHV GSGTVETRKV MADLVVGNLE
AHFSGKPLLT PVV


Related products :

Catalog number Product name Quantity
EIAAB10691 Carbonyl reductase II,DCXR,Dicarbonyl_L-xylulose reductase,Homo sapiens,Human,kiDCR,Kidney dicarbonyl reductase,L-xylulose reductase,Sperm surface protein P34H,XR
EIAAB11124 7-dehydrocholesterol reductase,7-DHC reductase,D7SR,DHCR7,Homo sapiens,Human,Putative sterol reductase SR-2,Sterol Delta(7)-reductase
EIAAB11126 7-dehydrocholesterol reductase,7-DHC reductase,Bos taurus,Bovine,DHCR7,Sterol Delta(7)-reductase
EIAAB11127 7-dehydrocholesterol reductase,7-DHC reductase,Dhcr7,Rat,Rattus norvegicus,Sterol Delta(7)-reductase
EIAAB11125 7-dehydrocholesterol reductase,7-DHC reductase,Dhcr7,Mouse,Mus musculus,Sterol Delta(7)-reductase
E2220h AKR1B1,Aldehyde reductase,Aldo-keto reductase family 1 member B1,Aldose reductase,ALDR1,AR,Homo sapiens,Human
U2220h CLIA AKR1B1,Aldehyde reductase,Aldo-keto reductase family 1 member B1,Aldose reductase,ALDR1,AR,Homo sapiens,Human 96T
E2220h ELISA kit AKR1B1,Aldehyde reductase,Aldo-keto reductase family 1 member B1,Aldose reductase,ALDR1,AR,Homo sapiens,Human 96T
U2220h CLIA kit AKR1B1,Aldehyde reductase,Aldo-keto reductase family 1 member B1,Aldose reductase,ALDR1,AR,Homo sapiens,Human 96T
E2220h ELISA AKR1B1,Aldehyde reductase,Aldo-keto reductase family 1 member B1,Aldose reductase,ALDR1,AR,Homo sapiens,Human 96T
EIAAB13217 ANG1,Another new gene 1 protein,C-14 sterol reductase,Delta(14)-sterol reductase,Delta-14-SR,Homo sapiens,Human,Putative sterol reductase SR-1,Sterol C14-reductase,TM7SF2,Transmembrane 7 superfamily m
EIAAB05627 3-oxoacyl-[acyl-carrier-protein] reductase,Carbonyl reductase family member 4,Cbr4,Mouse,Mus musculus,Quinone reductase CBR4
EIAAB05625 3-oxoacyl-[acyl-carrier-protein] reductase,Bos taurus,Bovine,Carbonyl reductase family member 4,CBR4,Quinone reductase CBR4
EIAAB05628 3-oxoacyl-[acyl-carrier-protein] reductase,Carbonyl reductase family member 4,Cbr4,Quinone reductase CBR4,Rat,Rattus norvegicus
EIAAB05626 3-oxoacyl-[acyl-carrier-protein] reductase,Carbonyl reductase family member 4,CBR4,Homo sapiens,Human,Quinone reductase CBR4
EIAAB11121 24-dehydrocholesterol reductase,3-beta-hydroxysterol delta-24-reductase,Delta(24)-sterol reductase,Dhcr24,Kiaa0018,Mouse,Mus musculus
EIAAB11123 24-dehydrocholesterol reductase,3-beta-hydroxysterol delta-24-reductase,Delta(24)-sterol reductase,DHCR24,Diminuto_dwarf1 homolog,Homo sapiens,Human,KIAA0018,Seladin-1
EIAAB11122 24-dehydrocholesterol reductase,3-beta-hydroxysterol delta-24-reductase,Delta(24)-sterol reductase,Dhcr24,Rat,Rattus norvegicus
EIAAB25528 Homo sapiens,Human,Mitochondrial peptide methionine sulfoxide reductase,MSRA,Peptide Met(O) reductase,Peptide-methionine (S)-S-oxide reductase,PMSR,Protein-methionine-S-oxide reductase
EIAAB27759 Azoreductase,DTD,DT-diaphorase,Menadione reductase,NAD(P)H dehydrogenase [quinone] 1,NAD(P)H quinone oxidoreductase 1,Nmor1,Nqo1,Phylloquinone reductase,QR1,Quinone reductase 1,Rat,Rattus norvegicus
EIAAB27760 Azoreductase,DIA4,DTD,DT-diaphorase,Homo sapiens,Human,Menadione reductase,NAD(P)H dehydrogenase [quinone] 1,NAD(P)H quinone oxidoreductase 1,NMOR1,NQO1,Phylloquinone reductase,QR1,Quinone reductase 1
EIAAB25530 Mitochondrial peptide methionine sulfoxide reductase,Mouse,Msra,Mus musculus,Peptide Met(O) reductase,Peptide-methionine (S)-S-oxide reductase,PMSR,Protein-methionine-S-oxide reductase
EIAAB25529 Mitochondrial peptide methionine sulfoxide reductase,Msra,Peptide Met(O) reductase,Peptide-methionine (S)-S-oxide reductase,PMSR,Protein-methionine-S-oxide reductase,Rat,Rattus norvegicus
EIAAB44144 NADPH-dependent thioredoxin reductase,Rat,Rattus norvegicus,Thioredoxin reductase 1, cytoplasmic,Thioredoxin reductase TR1,TR,Trxr1,Txnrd1
E94251Hu ELISA Kit for 4-Hydroxyphenylpyruvate Dioxygenase (HPD) 96T/Kit


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur