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Hypoxia induced factor 2 alpha

 V9P1Z1_CLABA            Unreviewed;       818 AA.
V9P1Z1;
19-MAR-2014, integrated into UniProtKB/TrEMBL.
19-MAR-2014, sequence version 1.
25-OCT-2017, entry version 25.
SubName: Full=Hypoxia induced factor 2 alpha {ECO:0000313|EMBL:AGT15727.1};
Name=HIF-2 alpha {ECO:0000313|EMBL:AGT15727.1};
Clarias batrachus (Walking catfish) (Silurus batrachus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
Clariidae; Clarias.
NCBI_TaxID=59899 {ECO:0000313|EMBL:AGT15727.1};
[1] {ECO:0000313|EMBL:AGT15727.1}
NUCLEOTIDE SEQUENCE.
Mohindra V., Tripathi R.K., Singh R.K.;
"Molecular characterization of hypoxia-inducible factor alpha
subunitsin Indian catfish, Clarias batrachus [Linnaeus, 1758].";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00895706}.
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EMBL; KC011346; AGT15727.1; -; mRNA.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
CDD; cd00130; PAS; 2.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR014887; HIF-1_TAD_C.
InterPro; IPR021537; HIF_alpha_subunit.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR001610; PAC.
InterPro; IPR000014; PAS.
InterPro; IPR035965; PAS-like_dom_sf.
InterPro; IPR013767; PAS_fold.
Pfam; PF11413; HIF-1; 1.
Pfam; PF08778; HIF-1a_CTAD; 1.
Pfam; PF00989; PAS; 1.
SMART; SM00353; HLH; 1.
SMART; SM00086; PAC; 1.
SMART; SM00091; PAS; 2.
SUPFAM; SSF47459; SSF47459; 1.
SUPFAM; SSF55785; SSF55785; 2.
TIGRFAMs; TIGR00229; sensory_box; 2.
PROSITE; PS50888; BHLH; 1.
PROSITE; PS50112; PAS; 2.
2: Evidence at transcript level;
Nucleus {ECO:0000256|SAAS:SAAS00896251};
Repeat {ECO:0000256|SAAS:SAAS00895860};
Transcription {ECO:0000256|SAAS:SAAS00896243};
Transcription regulation {ECO:0000256|SAAS:SAAS00896243}.
DOMAIN 14 67 BHLH. {ECO:0000259|PROSITE:PS50888}.
DOMAIN 77 145 PAS. {ECO:0000259|PROSITE:PS50112}.
DOMAIN 244 295 PAS. {ECO:0000259|PROSITE:PS50112}.
MOD_RES 394 394 4-hydroxyproline.
{ECO:0000256|PIRSR:PIRSR621537-50}.
MOD_RES 512 512 4-hydroxyproline.
{ECO:0000256|PIRSR:PIRSR621537-50}.
MOD_RES 795 795 (3S)-3-hydroxyasparagine.
{ECO:0000256|PIRSR:PIRSR621537-50}.
SEQUENCE 818 AA; 91598 MW; 224571E1068D58AC CRC64;
MTAEKDKKRS TTERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSISSH LDKASIMRLA
ISFLRTCKLL TSGCNTSETD IERQLDSLYL KSLEGFISVV TSDGDMIFLS ENINKFMGLT
QVELIGHSIF DFTHPCDHDE IRENLSLKTG AGNKGKELTT ERDFFMRMKC TVTSRGRTVN
LKSASWKVLH CTGHLKMYNS CPTRTLCGLK ESPLTCVVML CEPVPHPSNI DTPFDSKTFL
SRHSMDMKFT YCDERVTELI GYNPDDLLGR SVYEFYHALD SESVTRSHQN LCTKGQAVSG
QYRMLAKYGG FVWMETQGTV IYSSRNSQPQ CIVCVNYVLS DIEEKSTVFS KDQTESLLKT
HMSSFFSQTG STIDPENRLI KFKEEPEDLT HLAPTPGDGV IPLDFGRPSF EEFPVYSKVS
PVHPSANHSV TDGHNMPKLS ANFSIIQASP ASSATPVLSS CSLLNSPDEY KGPVDDLKME
ITEKLFAMDT QGKNSYNQET DLSDLDLETL APYIPMDGED FQLNPICQEE PRPETVAHGI
SQYSFSNIAN FFQPLTPPPG AHFQPDPHSA NEKQARSSTT VEPWPPIFYA SPMPLAHYTN
PASTPLSSVG GHHSLHWPPD PPINYSNIKG GVIDSLVEKH PCQALQSNHL SLQNLRSVEN
YEPCKAFRDI SPARLTVPTT MKRSFSQISM GVSHATTPLD VWKRMKSESC AVLNRMSQSS
SALTDEHVDH QHKKTRYQGN QTALGKKDYT EQCCNYSDYN MVPNTKMQGV ASRLLGPSFE
MYCLPELTRY DCEVNAPLQG NLHLLQGSDL LCALDQAT


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