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Hypoxia-inducible factor 2 alpha

 A0A088DJK3_9TELE        Unreviewed;       833 AA.
A0A088DJK3;
26-NOV-2014, integrated into UniProtKB/TrEMBL.
26-NOV-2014, sequence version 1.
31-JAN-2018, entry version 19.
SubName: Full=Hypoxia-inducible factor 2 alpha {ECO:0000313|EMBL:AIL95725.1};
Name=HIF2 {ECO:0000313|EMBL:AIL95725.1};
Gymnocypris przewalskii (Lake Qinghai scale-less carp).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Gymnocypris.
NCBI_TaxID=75348 {ECO:0000313|EMBL:AIL95725.1};
[1] {ECO:0000313|EMBL:AIL95725.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Liver {ECO:0000313|EMBL:AIL95725.1};
Zhang J., Cao Y.B., Ren J.L., Chen X.Q., Du J.Z.;
Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00895706}.
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EMBL; KJ921650; AIL95725.1; -; mRNA.
SMR; A0A088DJK3; -.
GO; GO:0005737; C:cytoplasm; IEA:InterPro.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
CDD; cd00130; PAS; 2.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR014887; HIF-1_TAD_C.
InterPro; IPR021537; HIF_alpha_subunit.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR001067; Nuc_translocat.
InterPro; IPR001610; PAC.
InterPro; IPR000014; PAS.
InterPro; IPR035965; PAS-like_dom_sf.
InterPro; IPR013767; PAS_fold.
InterPro; IPR013655; PAS_fold_3.
Pfam; PF11413; HIF-1; 1.
Pfam; PF08778; HIF-1a_CTAD; 1.
Pfam; PF00989; PAS; 1.
Pfam; PF08447; PAS_3; 1.
PRINTS; PR00785; NCTRNSLOCATR.
SMART; SM00353; HLH; 1.
SMART; SM00086; PAC; 1.
SMART; SM00091; PAS; 2.
SUPFAM; SSF47459; SSF47459; 1.
SUPFAM; SSF55785; SSF55785; 2.
TIGRFAMs; TIGR00229; sensory_box; 2.
PROSITE; PS50888; BHLH; 1.
PROSITE; PS50112; PAS; 2.
2: Evidence at transcript level;
Nucleus {ECO:0000256|SAAS:SAAS00896251};
Repeat {ECO:0000256|SAAS:SAAS00895860};
Transcription {ECO:0000256|SAAS:SAAS00896243};
Transcription regulation {ECO:0000256|SAAS:SAAS00896243}.
DOMAIN 17 70 BHLH. {ECO:0000259|PROSITE:PS50888}.
DOMAIN 82 159 PAS. {ECO:0000259|PROSITE:PS50112}.
DOMAIN 249 300 PAS. {ECO:0000259|PROSITE:PS50112}.
MOD_RES 403 403 4-hydroxyproline.
{ECO:0000256|PIRSR:PIRSR621537-50}.
MOD_RES 529 529 4-hydroxyproline.
{ECO:0000256|PIRSR:PIRSR621537-50}.
MOD_RES 810 810 (3S)-3-hydroxyasparagine.
{ECO:0000256|PIRSR:PIRSR621537-50}.
SEQUENCE 833 AA; 93023 MW; 8ACFF372757BACDC CRC64;
MTAEKEKEKK KRCSSDRRKE KSRDAARYRR SKETEVFYEL ARQLPLSNST SSHLDKASIM
RLAISYLRTR KLLTSACATA TETTDVDRLM DSWYLKSLGG FISVVTSDGD IVFLSENINK
LMGLTQVELT GHSIFDFTHP CDHEEIRENL SLKAGMGKKG KELRTERDFF MRMKCTVTNR
GRTVNLKSAS WKVLHCTGHL KVYDGCPARV LCGFKEPPLT CVVMWCEPIA HPSNIDTPLD
SKTFLSRHSM DMKFTYCDDR VTELMGYNPE DLLGRSAYDF YHALDSDNVT KSHQNLCTKG
QAVSGQYRML AKNGGYVWVE TQGTVIYNSR NSQPQCIVCV NYVLSDVEEK SMIFSMDQTE
SLFKPQHLNR FFSPCKGGLG REPGEVLFTN LKDEPEDLNQ LAPTPGDTII SLDFGNPQYA
EHPMYSKVSA VAPAVSHPGH DGLKTSYAGD MAKMATTFSV PQAPPASSTT PSLSSCSTPS
SPEDYFTSVD SDLKVELTEK MFSLDTQETK TSCDQETDLS DLDLETLAPY IPMDGEDFQL
NPICQEEPSS EIGGLGTNQQ SFSNITSLFQ PLSSPSAAHF QPNMSSGGDK QSINGGSVAS
WPSVPYSRGP MQMPPYHDPA STPLSSMGGR QNLQWPPDPS FPSKAGMMDP LAAKRSCQTL
PANRMHPYFQ SPMENFVQNY RDISPARLAL ANNFKRSFTQ MTMNEPPTTK SQHTMWKRLR
NESCAVMDRK SLSTSALSDK GMEHHLHRKT QYSGNQAGQA TKCFREECCN YREFNMQPSS
KMEGIASRLI GPSFETYSLP ELTRYDCEVN VPLQGNLHLL QGSDLLRALD QAT


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