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IFNa1 (Interferon alpha 1) (interferon alpha 1 precursor)

 Q6XQG7_SALSA            Unreviewed;       175 AA.
Q6XQG7;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
22-NOV-2017, entry version 84.
SubName: Full=IFNa1 {ECO:0000313|EMBL:ACE75690.1};
SubName: Full=Interferon alpha 1 {ECO:0000313|EMBL:AAP51035.1};
SubName: Full=interferon alpha 1 precursor {ECO:0000313|RefSeq:NP_001117182.1};
Name=IFNA1 {ECO:0000313|EMBL:AAP51035.1};
Synonyms=ifna1 {ECO:0000313|RefSeq:NP_001117182.1};
Salmo salar (Atlantic salmon).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Salmo.
NCBI_TaxID=8030 {ECO:0000313|EMBL:AAP51035.1};
[1] {ECO:0000313|EMBL:AAP51035.1, ECO:0000313|RefSeq:NP_001117182.1}
NUCLEOTIDE SEQUENCE.
PubMed=14585200; DOI=10.1089/107999003322485107;
Robertsen B., Bergan V., Rokenes T., Larsen R., Albuquerque A.;
"Atlantic salmon interferon genes: cloning, sequence analysis,
expression, and biological activity.";
J. Interferon Cytokine Res. 23:601-612(2003).
[2] {ECO:0000313|EMBL:ABD39320.1, ECO:0000313|RefSeq:NP_001117182.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Sperm {ECO:0000313|EMBL:ABD39320.1};
PubMed=16889635; DOI=10.1111/j.1742-4658.2006.05382.x;
Bergan V., Steinsvik S., Xu H., Kileng O., Robertsen B.;
"Promoters of type I interferon genes from Atlantic salmon contain two
main regulatory regions.";
FEBS J. 273:3893-3906(2006).
[3] {ECO:0000313|EMBL:ACE75690.1}
NUCLEOTIDE SEQUENCE.
PubMed=19007809; DOI=10.1016/j.dci.2008.10.001;
Sun B., Robertsen B., Wang Z., Liu B.;
"Identification of an Atlantic salmon IFN multigene cluster encoding
three IFN subtypes with very different expression properties.";
Dev. Comp. Immunol. 33:547-558(2009).
[4] {ECO:0000313|RefSeq:NP_001117182.1}
NUCLEOTIDE SEQUENCE.
PubMed=23169587; DOI=10.4049/jimmunol.1201188;
Svingerud T., Solstad T., Sun B., Nyrud M.L., Kileng O.,
Greiner-Tollersrud L., Robertsen B.;
"Atlantic salmon type I IFN subtypes show differences in antiviral
activity and cell-dependent expression: evidence for high IFNb/IFNc-
producing cells in fish lymphoid tissues.";
J. Immunol. 189:5912-5923(2012).
[5] {ECO:0000313|RefSeq:NP_001117182.1}
IDENTIFICATION.
RefSeq;
Submitted (JUN-2017) to UniProtKB.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00135286}.
-!- SIMILARITY: Belongs to the alpha/beta interferon family.
{ECO:0000256|RuleBase:RU000436, ECO:0000256|SAAS:SAAS00562792}.
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EMBL; AY216594; AAP51035.1; -; mRNA.
EMBL; DQ354152; ABD39320.1; -; Genomic_DNA.
EMBL; EU768890; ACE75690.1; -; Genomic_DNA.
RefSeq; NP_001117182.1; NM_001123710.1.
UniGene; Ssa.38457; -.
GeneID; 100137019; -.
CTD; 3439; -.
HOVERGEN; HBG056621; -.
Proteomes; UP000087266; Genome assembly.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
GO; GO:0051607; P:defense response to virus; IDA:AgBase.
GO; GO:1902615; P:immune response involved in response to exogenous dsRNA; IMP:AgBase.
GO; GO:0031342; P:negative regulation of cell killing; IDA:AgBase.
GO; GO:0045918; P:negative regulation of cytolysis; IDA:AgBase.
GO; GO:0010629; P:negative regulation of gene expression; IMP:AgBase.
GO; GO:0048525; P:negative regulation of viral process; IMP:AgBase.
GO; GO:1904972; P:negative regulation of viral translation; IDA:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; IMP:AgBase.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:AgBase.
GO; GO:0060337; P:type I interferon signaling pathway; IMP:AgBase.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000471; Interferon_alpha/beta/delta.
InterPro; IPR015588; Interferon_beta.
PANTHER; PTHR11691; PTHR11691; 1.
PANTHER; PTHR11691:SF43; PTHR11691:SF43; 1.
Pfam; PF00143; Interferon; 1.
SMART; SM00076; IFabd; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense {ECO:0000256|RuleBase:RU000436,
ECO:0000256|SAAS:SAAS00065439};
Complete proteome {ECO:0000313|Proteomes:UP000087266};
Cytokine {ECO:0000256|RuleBase:RU000436,
ECO:0000256|SAAS:SAAS00449409};
Disulfide bond {ECO:0000256|SAAS:SAAS00135285};
Reference proteome {ECO:0000313|Proteomes:UP000087266};
Secreted {ECO:0000256|SAAS:SAAS00135283};
Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001117182.1}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 175 {ECO:0000256|SAM:SignalP,
ECO:0000313|RefSeq:NP_001117182.1}.
/FTId=PRO_5009732071.
SEQUENCE 175 AA; 20846 MW; 1D2202E6CEAD59B9 CRC64;
MYTVQSWTCI CLIICSMQSV CHCCDWIRHH YGHLSSEYLS LLDQMGGDIT KQDAPVFFPT
SLYRHIDDAE VEDQVRFLKE TIYQITKLFD GNMKSVTWDK KKLDDFLNIL ERQLENLKSC
VSPAMKPEKR LKRYFKKLNK NVLRKMNYSA QAWELIRKET KRHLQRLDIL AAQMY


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