GENTAUR Molecular Products.

 A0A172WIT1_9EURY        Unreviewed;       196 AA.
 A0A172WIT1;
 07-SEP-2016, integrated into UniProtKB/TrEMBL.
 07-SEP-2016, sequence version 1.
 20-DEC-2017, entry version 12.
 RecName: Full=IMP cyclohydrolase {ECO:0000256|HAMAP-Rule:MF_00705};
          EC=3.5.4.10 {ECO:0000256|HAMAP-Rule:MF_00705};
 AltName: Full=IMP synthase {ECO:0000256|HAMAP-Rule:MF_00705};
 AltName: Full=Inosinicase {ECO:0000256|HAMAP-Rule:MF_00705};
 Name=purO {ECO:0000256|HAMAP-Rule:MF_00705};
 ORFNames=A7C91_09090 {ECO:0000313|EMBL:ANF23307.1};
 Thermococcus piezophilus.
 Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
 Thermococcus.
 NCBI_TaxID=1712654 {ECO:0000313|EMBL:ANF23307.1, ECO:0000313|Proteomes:UP000076969};
 [1] {ECO:0000313|Proteomes:UP000076969}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=CDGS {ECO:0000313|Proteomes:UP000076969};
 Dalmasso C., Oger P.M., Selva G., Courtine D., L'Haridon S.,
 Garlaschelli A., Roussel E., Miyazaki J., Takai K., Maignien L.,
 Alain K.;
 "Thermococcus superprofundus sp. nov., an hyperthermophilic Archaeon
 with a broad pressure range for growth, isolated from the Mid-Cayman
 Rise.";
 Syst. Appl. Microbiol. 0:0-0(2016).
 -!- FUNCTION: Catalyzes the cyclization of 5-formylamidoimidazole-4-
     carboxamide ribonucleotide to IMP. {ECO:0000256|HAMAP-
     Rule:MF_00705}.
 -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
     ribosyl)imidazole-4-carboxamide. {ECO:0000256|HAMAP-
     Rule:MF_00705}.
 -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
     IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
     carboxamide: step 1/1. {ECO:0000256|HAMAP-Rule:MF_00705}.
 -!- SIMILARITY: Belongs to the archaeal IMP cyclohydrolase family.
     {ECO:0000256|HAMAP-Rule:MF_00705}.
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 EMBL; CP015520; ANF23307.1; -; Genomic_DNA.
 RefSeq; WP_068666833.1; NZ_CP015520.1.
 EnsemblBacteria; ANF23307; ANF23307; A7C91_09090.
 GeneID; 28496346; -.
 KEGG; tpie:A7C91_09090; -.
 KO; K11176; -.
 UniPathway; UPA00074; UER00135.
 Proteomes; UP000076969; Chromosome.
 GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-UniRule.
 GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
 Gene3D; 3.60.20.20; -; 1.
 HAMAP; MF_00705; IMP_cyclohydrol; 1.
 InterPro; IPR010191; IMP_cyclohydrolase.
 InterPro; IPR020600; IMP_cyclohydrolase-like.
 InterPro; IPR036795; IMP_cyclohydrolase-like_sf.
 Pfam; PF07826; IMP_cyclohyd; 1.
 PIRSF; PIRSF004866; IMP_cclhdr_arch; 1.
 SUPFAM; SSF75569; SSF75569; 1.
 TIGRFAMs; TIGR01922; purO_arch; 1.
 3: Inferred from homology;
 Coiled coil {ECO:0000256|SAM:Coils};
 Complete proteome {ECO:0000313|Proteomes:UP000076969};
 Hydrolase {ECO:0000256|HAMAP-Rule:MF_00705,
 ECO:0000313|EMBL:ANF23307.1};
 Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00705}.
 DOMAIN        3    187       IMP_cyclohyd. {ECO:0000259|Pfam:PF07826}.
 COILED      152    172       {ECO:0000256|SAM:Coils}.
 SEQUENCE   196 AA;  22084 MW;  963E934489802D8A CRC64;
 MRYVGRMLGV GLNNGRPFAF YRLNSRSFPN RRAVIRGNEI YIANQTETDN PYVSYPVVKL
 LENYAVVSNG LQTVFMAQAL EEESPRKALI HVLDALDYER DDYSTPRIAV IVECGKARGW
 LGFVGREELW VKAIKLEEGK ALFTATYNVD GIEELELSFS NAEELAEKVL RLEFSHPVLA
 IAVVEKEGGW KAAVKP

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