GENTAUR Molecular Products.

 PURO_METVS              Reviewed;         201 AA.
 A6UPV4;
 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
 21-AUG-2007, sequence version 1.
 28-MAR-2018, entry version 63.
 RecName: Full=IMP cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00705};
          EC=3.5.4.10 {ECO:0000255|HAMAP-Rule:MF_00705};
 AltName: Full=IMP synthase {ECO:0000255|HAMAP-Rule:MF_00705};
 AltName: Full=Inosinicase {ECO:0000255|HAMAP-Rule:MF_00705};
 Name=purO {ECO:0000255|HAMAP-Rule:MF_00705};
 OrderedLocusNames=Mevan_0620;
 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 /
 OCM 148 / SB).
 Archaea; Euryarchaeota; Methanococci; Methanococcales;
 Methanococcaceae; Methanococcus.
 NCBI_TaxID=406327;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
 US DOE Joint Genome Institute;
 Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
 Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M.,
 Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
 Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
 "Complete sequence of Methanococcus vannielii SB.";
 Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
 -!- FUNCTION: Catalyzes the cyclization of 5-formylamidoimidazole-4-
     carboxamide ribonucleotide to IMP. {ECO:0000255|HAMAP-
     Rule:MF_00705}.
 -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
     ribosyl)imidazole-4-carboxamide. {ECO:0000255|HAMAP-
     Rule:MF_00705}.
 -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
     IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
     carboxamide: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00705}.
 -!- SIMILARITY: Belongs to the archaeal IMP cyclohydrolase family.
     {ECO:0000255|HAMAP-Rule:MF_00705}.
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 EMBL; CP000742; ABR54526.1; -; Genomic_DNA.
 RefSeq; WP_011972429.1; NC_009634.1.
 ProteinModelPortal; A6UPV4; -.
 SMR; A6UPV4; -.
 STRING; 406327.Mevan_0620; -.
 EnsemblBacteria; ABR54526; ABR54526; Mevan_0620.
 GeneID; 5325073; -.
 KEGG; mvn:Mevan_0620; -.
 eggNOG; arCOG04727; Archaea.
 eggNOG; COG3363; LUCA.
 HOGENOM; HOG000015497; -.
 KO; K11176; -.
 OMA; SHVDPIA; -.
 OrthoDB; POG093Z0CY5; -.
 BioCyc; MVAN406327:G1G99-638-MONOMER; -.
 UniPathway; UPA00074; UER00135.
 Proteomes; UP000001107; Chromosome.
 GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-EC.
 GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
 Gene3D; 3.60.20.20; -; 1.
 HAMAP; MF_00705; IMP_cyclohydrol; 1.
 InterPro; IPR010191; IMP_cyclohydrolase.
 InterPro; IPR020600; IMP_cyclohydrolase-like.
 InterPro; IPR036795; IMP_cyclohydrolase-like_sf.
 Pfam; PF07826; IMP_cyclohyd; 1.
 PIRSF; PIRSF004866; IMP_cclhdr_arch; 1.
 SUPFAM; SSF75569; SSF75569; 1.
 TIGRFAMs; TIGR01922; purO_arch; 1.
 3: Inferred from homology;
 Complete proteome; Hydrolase; Purine biosynthesis.
 CHAIN         1    201       IMP cyclohydrolase.
                              /FTId=PRO_0000349166.
 SEQUENCE   201 AA;  22905 MW;  F93A24E5F4C6799D CRC64;
 MYIGRFLVLG KTLNGKPFVT YRVSSRSFPN RIAKIMNDET VAILPKNLEE MFKNPYITYN
 CVKIVGNIAV VTNGSHTDII ADKIRIGLPI RDALSYSLLT MDYEKDDFNT PRIAAVLTDN
 EAYMGYVSDN DIRIKKVELE EGYAYYLSTY EACKITEHQK IEVSKNTPED LCKFIMEHNE
 FEKPVTSTTV LMDSGFKIAT L

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