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IMP cyclohydrolase (EC 3.5.4.10) (IMP synthase) (Inosinicase)

 D3SVC2_NATMM            Unreviewed;       198 AA.
D3SVC2;
20-APR-2010, integrated into UniProtKB/TrEMBL.
20-APR-2010, sequence version 1.
28-MAR-2018, entry version 49.
RecName: Full=IMP cyclohydrolase {ECO:0000256|HAMAP-Rule:MF_00705};
EC=3.5.4.10 {ECO:0000256|HAMAP-Rule:MF_00705};
AltName: Full=IMP synthase {ECO:0000256|HAMAP-Rule:MF_00705};
AltName: Full=Inosinicase {ECO:0000256|HAMAP-Rule:MF_00705};
Name=purO {ECO:0000256|HAMAP-Rule:MF_00705,
ECO:0000313|EMBL:ADD05530.1};
OrderedLocusNames=Nmag_1959 {ECO:0000313|EMBL:ADD05530.1};
ORFNames=C500_10603 {ECO:0000313|EMBL:ELY29508.1};
Natrialba magadii (strain ATCC 43099 / DSM 3394 / CIP 104546 / JCM
8861/ NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium magadii).
Archaea; Euryarchaeota; Halobacteria; Natrialbales; Natrialbaceae;
Natrialba.
NCBI_TaxID=547559 {ECO:0000313|EMBL:ADD05530.1, ECO:0000313|Proteomes:UP000001879};
[1] {ECO:0000313|Proteomes:UP000001879}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43099 / DSM 3394 / CIP 104546 / JCM 8861/ NBRC 102185 /
NCIMB 2190 / MS3 {ECO:0000313|Proteomes:UP000001879};
US DOE Joint Genome Institute;
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R.,
Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E.,
Maupin-Furlow J.A., Woyke T.;
"Complete sequence of chromosome of Natrialba magadii ATCC 43099.";
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:ADD05530.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD05530.1};
PubMed=22559199; DOI=10.1186/1471-2164-13-165;
Siddaramappa S., Challacombe J.F., Decastro R.E., Pfeiffer F.,
Sastre D.E., Gimenez M.I., Paggi R.A., Detter J.C., Davenport K.W.,
Goodwin L.A., Kyrpides N., Tapia R., Pitluck S., Lucas S., Woyke T.,
Maupin-Furlow J.A.;
"A comparative genomics perspective on the genetic content of the
alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T.";
BMC Genomics 13:165-165(2012).
[3] {ECO:0000313|Proteomes:UP000011543}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43099 / DSM 3394 / CIP 104546 / JCM 8861/ NBRC 102185 /
NCIMB 2190 / MS3 {ECO:0000313|Proteomes:UP000011543};
Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D.,
Darling A., Eisen J.A., Facciotti M.T.;
Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:ELY29508.1}
NUCLEOTIDE SEQUENCE.
STRAIN=MS-3 {ECO:0000313|EMBL:ELY29508.1};
PubMed=25393412;
Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I.,
Wu D., Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
"Phylogenetically driven sequencing of extremely halophilic archaea
reveals strategies for static and dynamic osmo-response.";
PLoS Genet. 10:E1004784-E1004784(2014).
[5] {ECO:0000313|EMBL:ADD05530.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD05530.1};
Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the cyclization of 5-formylamidoimidazole-4-
carboxamide ribonucleotide to IMP. {ECO:0000256|HAMAP-
Rule:MF_00705}.
-!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
ribosyl)imidazole-4-carboxamide. {ECO:0000256|HAMAP-
Rule:MF_00705}.
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
carboxamide: step 1/1. {ECO:0000256|HAMAP-Rule:MF_00705}.
-!- SIMILARITY: Belongs to the archaeal IMP cyclohydrolase family.
{ECO:0000256|HAMAP-Rule:MF_00705}.
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EMBL; CP001932; ADD05530.1; -; Genomic_DNA.
EMBL; AOHS01000036; ELY29508.1; -; Genomic_DNA.
RefSeq; WP_004267493.1; NZ_AOHS01000036.1.
STRING; 547559.Nmag_1959; -.
EnsemblBacteria; ADD05530; ADD05530; Nmag_1959.
EnsemblBacteria; ELY29508; ELY29508; C500_10603.
GeneID; 8824800; -.
KEGG; nmg:Nmag_1959; -.
PATRIC; fig|547559.17.peg.2096; -.
eggNOG; arCOG04727; Archaea.
eggNOG; COG3363; LUCA.
HOGENOM; HOG000015497; -.
KO; K11176; -.
OMA; SHVDPIA; -.
OrthoDB; POG093Z0CY5; -.
BioCyc; NMAG547559:G1GHK-1906-MONOMER; -.
UniPathway; UPA00074; UER00135.
Proteomes; UP000001879; Chromosome.
Proteomes; UP000011543; Unassembled WGS sequence.
GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-UniRule.
GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
Gene3D; 3.60.20.20; -; 1.
HAMAP; MF_00705; IMP_cyclohydrol; 1.
InterPro; IPR010191; IMP_cyclohydrolase.
InterPro; IPR020600; IMP_cyclohydrolase-like.
InterPro; IPR036795; IMP_cyclohydrolase-like_sf.
Pfam; PF07826; IMP_cyclohyd; 1.
PIRSF; PIRSF004866; IMP_cclhdr_arch; 1.
SUPFAM; SSF75569; SSF75569; 1.
TIGRFAMs; TIGR01922; purO_arch; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000001879};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_00705,
ECO:0000313|EMBL:ADD05530.1};
Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00705};
Reference proteome {ECO:0000313|Proteomes:UP000001879}.
DOMAIN 2 188 IMP_cyclohyd. {ECO:0000259|Pfam:PF07826}.
SEQUENCE 198 AA; 21176 MW; 4F4D7256A248A4D5 CRC64;
MYVGRFVVVG PEGGAYRVSS RSFPNRAITA RDDAEALTVG PTEDAPDTDN PYVSYNCLRV
VETPTGETVA FGNGSHVDPI AEKLELGYPA RDALAESLLA LDYEKDDYDT PRIAATITDD
GEALIGTVRK DALLVETVDE PTLVATYEKD TPEPIEFDAE SATAAASESY ALEFEHAVCA
AGVSRTEDGF ETAIENGD


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