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Immediate early response gene 2 protein (CHX1) (Cycloheximide-induced gene protein) (Growth factor-inducible immediate early protein) (Proline-rich-induced protein 92) (Pip92) (T-lymphocyte-activated protein)

 IER2_MOUSE              Reviewed;         221 AA.
P17950; Q3TD12; Q64251; Q8BME8; Q99M25;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
03-OCT-2012, sequence version 3.
25-OCT-2017, entry version 100.
RecName: Full=Immediate early response gene 2 protein;
AltName: Full=CHX1;
AltName: Full=Cycloheximide-induced gene protein;
AltName: Full=Growth factor-inducible immediate early protein;
AltName: Full=Proline-rich-induced protein 92;
Short=Pip92;
AltName: Full=T-lymphocyte-activated protein;
Name=Ier2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
PubMed=2308934; DOI=10.1073/pnas.87.5.1753;
Coleclough C., Kuhn L., Lefkovits I.;
"Regulation of mRNA abundance in activated T lymphocytes:
identification of mRNA species affected by the inhibition of protein
synthesis.";
Proc. Natl. Acad. Sci. U.S.A. 87:1753-1757(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
STRAIN=BALB/cJ;
PubMed=2247083; DOI=10.1128/MCB.10.12.6769;
Charles C.H., Simske J.S., O'Brien T.P., Lau L.F.;
"Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3
and PC12 cells.";
Mol. Cell. Biol. 10:6769-6774(1990).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BALB/cJ;
PubMed=8083220;
Latinkic B.V., Lau L.F.;
"Transcriptional activation of the immediate early gene pip92 by serum
growth factors requires both Ets and CArG-like elements.";
J. Biol. Chem. 269:23163-23170(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD; TISSUE=Lung, and Wolffian duct;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: DNA-binding protein that seems to act as a transcription
factor (By similarity). Involved in the regulation of neuronal
differentiation, acts upon JNK-signaling pathway activation and
plays a role in neurite outgrowth in hippocampal cells (By
similarity). May mediate with FIBP FGF-signaling in the
establishment of laterality in the embryo (By similarity).
Promotes cell motility, seems to stimulate tumor metastasis (By
similarity). {ECO:0000250|UniProtKB:B7SXM5,
ECO:0000250|UniProtKB:Q6P7D3, ECO:0000250|UniProtKB:Q9BTL4}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BTL4}.
Nucleus {ECO:0000250|UniProtKB:Q9BTL4}. Note=Cytoplasmic during
quiescence, translocates to the nucleus upon stimulation.
{ECO:0000250|UniProtKB:Q9BTL4}.
-!- INDUCTION: By growth factors and cycloheximide.
{ECO:0000269|PubMed:2247083, ECO:0000269|PubMed:2308934}.
-!- SIMILARITY: Belongs to the IER family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M31042; AAA40059.1; -; mRNA.
EMBL; M59821; AAA39931.1; -; mRNA.
EMBL; L26490; AAB00120.1; -; Genomic_DNA.
EMBL; AK032692; BAC27990.1; -; mRNA.
EMBL; AK144601; BAE25960.1; -; mRNA.
EMBL; AK170433; BAE41793.1; -; mRNA.
EMBL; AC145556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC002067; AAH02067.1; -; mRNA.
CCDS; CCDS22474.1; -.
PIR; A54722; A36370.
RefSeq; NP_034629.3; NM_010499.4.
UniGene; Mm.399; -.
ProteinModelPortal; P17950; -.
STRING; 10090.ENSMUSP00000060275; -.
iPTMnet; P17950; -.
PhosphoSitePlus; P17950; -.
PaxDb; P17950; -.
PRIDE; P17950; -.
Ensembl; ENSMUST00000060427; ENSMUSP00000060275; ENSMUSG00000053560.
GeneID; 15936; -.
KEGG; mmu:15936; -.
UCSC; uc009mmr.2; mouse.
CTD; 9592; -.
MGI; MGI:104815; Ier2.
eggNOG; ENOG410IXGG; Eukaryota.
eggNOG; ENOG410Z3CN; LUCA.
GeneTree; ENSGT00900000141021; -.
HOGENOM; HOG000112998; -.
HOVERGEN; HBG068883; -.
InParanoid; P17950; -.
OMA; CEAKPAC; -.
OrthoDB; EOG091G0HLK; -.
TreeFam; TF331376; -.
ChiTaRS; Ier2; mouse.
PRO; PR:P17950; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000053560; -.
CleanEx; MM_IER2; -.
Genevisible; P17950; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding; ISO:MGI.
GO; GO:0048870; P:cell motility; ISS:UniProtKB.
GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
GO; GO:0071774; P:response to fibroblast growth factor; ISS:UniProtKB.
InterPro; IPR008653; IER.
PANTHER; PTHR15895; PTHR15895; 1.
Pfam; PF05760; IER; 1.
2: Evidence at transcript level;
Acetylation; Complete proteome; Cytoplasm; Nucleus;
Reference proteome.
CHAIN 1 221 Immediate early response gene 2 protein.
/FTId=PRO_0000190436.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:Q9BTL4}.
CONFLICT 27 27 G -> D (in Ref. 1; AAA40059).
{ECO:0000305}.
CONFLICT 46 46 V -> L (in Ref. 1; AAA40059, 2; AAA39931
and 3; AAB00120). {ECO:0000305}.
CONFLICT 59 59 F -> S (in Ref. 1; AAA40059).
{ECO:0000305}.
CONFLICT 76 76 A -> D (in Ref. 4; BAC27990).
{ECO:0000305}.
CONFLICT 92 92 E -> G (in Ref. 4; BAC27990).
{ECO:0000305}.
CONFLICT 130 130 G -> S (in Ref. 1; AAA40059, 2; AAA39931
and 3; AAB00120). {ECO:0000305}.
CONFLICT 183 183 L -> F (in Ref. 4; BAC27990).
{ECO:0000305}.
SEQUENCE 221 AA; 24459 MW; 661D2E167EC5D081 CRC64;
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSAREVYLSA KVEAHQPEFP
PSRRALDPRL HPPREAEVAV EVASPEAVQP PEPMDTQEEV LRVQETPALC DPPPARVSRK
RRSSSDLSDG SDAGLVPSKK ARLEEVEGEA TSEVPDRLQL PPAQSEGAFP NLARVLQRRF
SSLLNCGPAV PPPTPPTCEA KPACRPADNM LNVLVRAVVA F


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