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Immunoglobulin-binding protein 1 (Alpha4 phosphoprotein) (CD79a-binding protein 1) (Lymphocyte signal transduction molecule alpha 4) (Protein phosphatase 2/4/6 regulatory subunit) (p52)

 IGBP1_MOUSE             Reviewed;         340 AA.
Q61249;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
12-SEP-2018, entry version 135.
RecName: Full=Immunoglobulin-binding protein 1;
AltName: Full=Alpha4 phosphoprotein;
AltName: Full=CD79a-binding protein 1;
AltName: Full=Lymphocyte signal transduction molecule alpha 4;
AltName: Full=Protein phosphatase 2/4/6 regulatory subunit;
AltName: Full=p52;
Name=Igbp1; Synonyms=Pc52;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=NZC; TISSUE=B-cell;
PubMed=7876543;
Inui S., Kuwahara K., Mizutani J., Maeda K., Kawai T., Nakayasu H.,
Sakaguchi N.;
"Molecular cloning of a cDNA clone encoding a phosphoprotein component
related to the Ig receptor-mediated signal transduction.";
J. Immunol. 154:2714-2723(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-63.
STRAIN=BALB/cJ; TISSUE=Liver;
PubMed=9573385; DOI=10.1016/S0378-1119(98)00079-1;
Maeda K., Inui S., Sanjo H., Sakaguchi N.;
"The gene structure and promoter analysis of mouse lymphocyte signal
transduction molecule alpha 4 that is related to the yeast TAP42
involved in a rapamycin-sensitive pathway.";
Gene 210:287-295(1998).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[4]
X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-223, AND INTERACTION WITH
MID1 AND PPP2CA.
PubMed=21454489; DOI=10.1074/jbc.M111.222414;
LeNoue-Newton M., Watkins G.R., Zou P., Germane K.L., McCorvey L.R.,
Wadzinski B.E., Spiller B.W.;
"The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding
domains of the Alpha4 protein are both required for Alpha4 to inhibit
PP2A degradation.";
J. Biol. Chem. 286:17665-17671(2011).
-!- FUNCTION: Associated to surface IgM-receptor; may be involved in
signal transduction. Involved in regulation of the catalytic
activity of the phosphatases PP2A, PP4 and PP6 by protecting their
partially folded catalytic subunits from degradative
polyubiquitination until they associate with regulatory subunits.
-!- SUBUNIT: Interacts with PPP2CB, and with PP4 and PP6. Interacts
with MID2. Interacts with ubiquitin (By similarity). Interacts
with partially folded PPP2CA, but not with the fully active
protein. Interacts with MID1. {ECO:0000250,
ECO:0000269|PubMed:21454489}.
-!- INTERACTION:
P67775:PPP2CA (xeno); NbExp=3; IntAct=EBI-7002233, EBI-712311;
P63330:Ppp2ca; NbExp=2; IntAct=EBI-7002233, EBI-397144;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
-!- TISSUE SPECIFICITY: Expressed in spleen, thymus, liver and brain.
Ubiquitously expressed in B lineage cell lines.
-!- DOMAIN: The UIM domain is required for protective effect on PP2A.
-!- PTM: Phosphorylated.
-!- PTM: Monoubiquitination by MID1 triggers calpain-mediated cleavage
and switches IGBP1 activity from protective to destructive.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the IGBP1/TAP42 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L31652; AAA67891.1; -; mRNA.
EMBL; AJ000633; CAA04190.1; -; Genomic_DNA.
EMBL; AJ223156; CAA11135.1; -; Genomic_DNA.
EMBL; AJ223157; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ223158; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ223159; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ223160; CAA11135.1; JOINED; Genomic_DNA.
EMBL; AJ000634; CAA04191.1; -; Genomic_DNA.
CCDS; CCDS30302.1; -.
PIR; I49451; I49451.
RefSeq; NP_032810.4; NM_008784.3.
UniGene; Mm.7454; -.
PDB; 3QC1; X-ray; 2.35 A; A=1-223.
PDBsum; 3QC1; -.
ProteinModelPortal; Q61249; -.
SMR; Q61249; -.
BioGrid; 202041; 5.
IntAct; Q61249; 4.
MINT; Q61249; -.
STRING; 10090.ENSMUSP00000033570; -.
iPTMnet; Q61249; -.
PhosphoSitePlus; Q61249; -.
REPRODUCTION-2DPAGE; Q61249; -.
EPD; Q61249; -.
MaxQB; Q61249; -.
PaxDb; Q61249; -.
PeptideAtlas; Q61249; -.
PRIDE; Q61249; -.
Ensembl; ENSMUST00000033570; ENSMUSP00000033570; ENSMUSG00000031221.
GeneID; 18518; -.
KEGG; mmu:18518; -.
UCSC; uc009tvz.2; mouse.
CTD; 3476; -.
MGI; MGI:1346500; Igbp1.
eggNOG; KOG2830; Eukaryota.
eggNOG; ENOG41110HD; LUCA.
GeneTree; ENSGT00390000002414; -.
HOGENOM; HOG000038526; -.
HOVERGEN; HBG052090; -.
InParanoid; Q61249; -.
KO; K17606; -.
OMA; FRPGHNL; -.
OrthoDB; EOG091G0ELO; -.
PhylomeDB; Q61249; -.
TreeFam; TF313433; -.
ChiTaRS; Igbp1; mouse.
EvolutionaryTrace; Q61249; -.
PRO; PR:Q61249; -.
Proteomes; UP000000589; Chromosome X.
Bgee; ENSMUSG00000031221; Expressed in 300 organ(s), highest expression level in vas deferens.
CleanEx; MM_IGBP1; -.
Genevisible; Q61249; MM.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005874; C:microtubule; IGI:UniProtKB.
GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:UniProtKB.
GO; GO:0019904; F:protein domain specific binding; IPI:UniProtKB.
GO; GO:0051721; F:protein phosphatase 2A binding; ISO:MGI.
GO; GO:0019888; F:protein phosphatase regulator activity; ISO:MGI.
GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IMP:MGI.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
GO; GO:0035308; P:negative regulation of protein dephosphorylation; IDA:UniProtKB.
GO; GO:0032873; P:negative regulation of stress-activated MAPK cascade; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0035306; P:positive regulation of dephosphorylation; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
GO; GO:0060632; P:regulation of microtubule-based movement; ISO:MGI.
GO; GO:0070555; P:response to interleukin-1; ISO:MGI.
GO; GO:0034612; P:response to tumor necrosis factor; ISO:MGI.
Gene3D; 1.25.40.540; -; 1.
InterPro; IPR038511; TAP42/TAP46-like_sf.
InterPro; IPR007304; TAP46-like.
PANTHER; PTHR10933; PTHR10933; 1.
Pfam; PF04177; TAP42; 1.
1: Evidence at protein level;
3D-structure; Acetylation; B-cell activation; Chaperone;
Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome;
Ubl conjugation.
CHAIN 1 340 Immunoglobulin-binding protein 1.
/FTId=PRO_0000218619.
DOMAIN 47 61 UIM. {ECO:0000305}.
REGION 99 203 Interaction with PPP2CA. {ECO:0000250}.
REGION 226 291 Interaction with MID1. {ECO:0000250}.
SITE 256 257 Cleavage; by calpain. {ECO:0000250}.
MOD_RES 242 242 N6-acetyllysine.
{ECO:0000250|UniProtKB:P78318}.
HELIX 13 29 {ECO:0000244|PDB:3QC1}.
HELIX 37 60 {ECO:0000244|PDB:3QC1}.
TURN 61 63 {ECO:0000244|PDB:3QC1}.
STRAND 65 67 {ECO:0000244|PDB:3QC1}.
TURN 74 76 {ECO:0000244|PDB:3QC1}.
HELIX 77 81 {ECO:0000244|PDB:3QC1}.
HELIX 82 90 {ECO:0000244|PDB:3QC1}.
HELIX 96 98 {ECO:0000244|PDB:3QC1}.
HELIX 99 114 {ECO:0000244|PDB:3QC1}.
HELIX 147 181 {ECO:0000244|PDB:3QC1}.
HELIX 187 219 {ECO:0000244|PDB:3QC1}.
SEQUENCE 340 AA; 38971 MW; 9C6BEF7C2E56BAE4 CRC64;
MAASEDELLL PRLPELFETS KKLLEDVEVA TEPTGSRTIQ DKVSKGLELL EKAAGMLSQL
DLFSRNEDLE EIASTDLKYL MVPALQGALT MKQVNPSKRL DHLQRAREHF VHFLTQCHCY
HVAEFQLPQT KTNSAENNTA SSSMAYPNLV AMASQRQAKI ERYKQKKEVE HRLSALKSAV
ESGQADDERV REYHLLHLRR WIAVSLEELE SIDQEIKILK EKDSPREETA CHSSLPEKPP
MKPFILTRNK AQAKVFGTGY PSLATMTVSD WYEQHQKYGV LPDRGIAKPA SADFQRAAQQ
QEDQEQKDEE SEEKALHRMR EWDDWKDTHP RGYGNRQNMG


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