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Importin beta-like SAD2 (Protein ENHANCED MIRNA ACTIVITY 1) (Protein SUPER SENSITIVE TO ABA AND DROUGHT 2) (Protein UNARMED 9)

 SAD2_ARATH              Reviewed;        1040 AA.
F4IRR2; Q56W71; Q8GZ12; Q9SIP2;
07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
28-JUN-2011, sequence version 1.
23-MAY-2018, entry version 57.
RecName: Full=Importin beta-like SAD2 {ECO:0000305};
AltName: Full=Protein ENHANCED MIRNA ACTIVITY 1 {ECO:0000303|PubMed:21984696};
AltName: Full=Protein SUPER SENSITIVE TO ABA AND DROUGHT 2 {ECO:0000303|PubMed:16889648};
AltName: Full=Protein UNARMED 9 {ECO:0000303|PubMed:19234066};
Name=SAD2 {ECO:0000303|PubMed:16889648};
Synonyms=EMA1 {ECO:0000303|PubMed:21984696},
URM9 {ECO:0000303|PubMed:19234066};
OrderedLocusNames=At2g31660 {ECO:0000312|Araport:AT2G31660};
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=11910074; DOI=10.1126/science.1071006;
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 669-1040.
STRAIN=cv. Columbia;
Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
Hayashizaki Y., Shinozaki K.;
"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
PubMed=16889648; DOI=10.1111/j.1365-313X.2006.02833.x;
Verslues P.E., Guo Y., Dong C.H., Ma W., Zhu J.K.;
"Mutation of SAD2, an importin beta-domain protein in Arabidopsis,
alters abscisic acid sensitivity.";
Plant J. 47:776-787(2006).
[6]
FUNCTION, AND INTERACTION WITH MYB4.
PubMed=17993626; DOI=10.1105/tpc.106.048900;
Zhao J., Zhang W., Zhao Y., Gong X., Guo L., Zhu G., Wang X., Gong Z.,
Schumaker K.S., Guo Y.;
"SAD2, an importin -like protein, is required for UV-B response in
Arabidopsis by mediating MYB4 nuclear trafficking.";
Plant Cell 19:3805-3818(2007).
[7]
FUNCTION.
PubMed=18713401; DOI=10.1111/j.1744-7909.2008.00695.x;
Gao Y., Gong X., Cao W., Zhao J., Fu L., Wang X., Schumaker K.S.,
Guo Y.;
"SAD2 in Arabidopsis functions in trichome initiation through
mediating GL3 function and regulating GL1, TTG1 and GL2 expression.";
J. Integr. Plant Biol. 50:906-917(2008).
[8]
FUNCTION.
PubMed=19234066; DOI=10.1242/dev.030585;
Yoshida Y., Sano R., Wada T., Takabayashi J., Okada K.;
"Jasmonic acid control of GLABRA3 links inducible defense and trichome
patterning in Arabidopsis.";
Development 136:1039-1048(2009).
[9]
FUNCTION.
PubMed=21984696; DOI=10.1105/tpc.111.091058;
Wang W., Ye R., Xin Y., Fang X., Li C., Shi H., Zhou X., Qi Y.;
"An importin beta protein negatively regulates microRNA activity in
Arabidopsis.";
Plant Cell 23:3565-3576(2011).
[10]
ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22223895; DOI=10.1074/mcp.M111.015131;
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C.,
Meinnel T., Giglione C.;
"Comparative large-scale characterisation of plant vs. mammal proteins
reveals similar and idiosyncratic N-alpha acetylation features.";
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
-!- FUNCTION: Functions probably in nuclear protein import, either by
acting as autonomous nuclear transport receptor or as an adapter-
like protein in association with other importin subunits
(Probable). Involved in the regulation of the abscisic acid (ABA)-
mediated pathway in response to cold or salt stress
(PubMed:16889648). Involved in UV-B responses by regulating
accumulation of UV-absorbing pigments through mediation of MYB4
nuclear transport (PubMed:17993626). Involved in trichome
initiation by controlling GL1, GL2, GL3 and TTG1 transcription and
may affect an upstream regulator of GL3 and disrupt complex
function (PubMed:18713401, PubMed:19234066). Acts as negative
regulator miRNA activity by regulating miRNA loading into AGO1
complexes (PubMed:21984696). {ECO:0000269|PubMed:16889648,
ECO:0000269|PubMed:17993626, ECO:0000269|PubMed:18713401,
ECO:0000269|PubMed:19234066, ECO:0000269|PubMed:21984696,
ECO:0000305}.
-!- SUBUNIT: Interacts with MYB4. {ECO:0000269|PubMed:17993626}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16889648}.
Nucleus {ECO:0000269|PubMed:16889648}.
-!- TISSUE SPECIFICITY: Expressed in roots, epidermal and guard cells
of leaves, stems and siliques. {ECO:0000269|PubMed:16889648}.
-!- DISRUPTION PHENOTYPE: Early flowering and increased sensitivity to
inhibition of seed germination and plant growth by exogenous ABA.
{ECO:0000269|PubMed:16889648}.
-!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD24843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=BAC41944.1; Type=Frameshift; Positions=154; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AC007071; AAD24843.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002685; AEC08570.1; -; Genomic_DNA.
EMBL; AK117271; BAC41944.1; ALT_FRAME; mRNA.
EMBL; AK222176; BAD95304.1; -; mRNA.
PIR; E84723; E84723.
RefSeq; NP_180724.2; NM_128723.3.
UniGene; At.46140; -.
ProteinModelPortal; F4IRR2; -.
STRING; 3702.AT2G31660.1; -.
iPTMnet; F4IRR2; -.
PaxDb; F4IRR2; -.
PRIDE; F4IRR2; -.
ProMEX; F4IRR2; -.
EnsemblPlants; AT2G31660.1; AT2G31660.1; AT2G31660.
GeneID; 817722; -.
Gramene; AT2G31660.1; AT2G31660.1; AT2G31660.
KEGG; ath:AT2G31660; -.
Araport; AT2G31660; -.
TAIR; locus:2065939; AT2G31660.
eggNOG; KOG1991; Eukaryota.
eggNOG; COG5656; LUCA.
HOGENOM; HOG000265678; -.
InParanoid; F4IRR2; -.
KO; K20223; -.
OMA; SCTFAAK; -.
OrthoDB; EOG093601DL; -.
Reactome; R-ATH-5578749; Transcriptional regulation by small RNAs.
PRO; PR:F4IRR2; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; F4IRR2; baseline and differential.
Genevisible; F4IRR2; AT.
GO; GO:0005737; C:cytoplasm; IDA:TAIR.
GO; GO:0005829; C:cytosol; IDA:TAIR.
GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0008565; F:protein transporter activity; IBA:GO_Central.
GO; GO:0008536; F:Ran GTPase binding; IEA:InterPro.
GO; GO:0035280; P:miRNA loading onto RISC involved in gene silencing by miRNA; IMP:TAIR.
GO; GO:0006606; P:protein import into nucleus; IDA:TAIR.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
Gene3D; 1.25.10.10; -; 1.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR013713; Cse1.
InterPro; IPR001494; Importin-beta_N.
Pfam; PF08506; Cse1; 1.
Pfam; PF03810; IBN_N; 1.
SMART; SM00913; IBN_N; 1.
SUPFAM; SSF48371; SSF48371; 1.
PROSITE; PS50166; IMPORTIN_B_NT; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Cytoplasm; Nucleus; Protein transport;
Reference proteome; Stress response; Transport.
CHAIN 1 1040 Importin beta-like SAD2.
/FTId=PRO_0000431577.
DOMAIN 25 103 Importin N-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00115}.
COMPBIAS 909 973 Asp-rich. {ECO:0000255|PROSITE-
ProRule:PRU00004}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000244|PubMed:22223895}.
SEQUENCE 1040 AA; 119247 MW; 256F8ABB354390AB CRC64;
MDLHSLALIL RTAALSPIPD ERKVSEQQLN QLEHTPQHLV RLLQIAVDGN CDMAVRQIAS
IQFKNLIAKN WSPEDCGPAV RQQQIFESDK ELVRDNILVY VTQVPTLLRS QLGESLKTII
YADYPEQWPR LLDWVKYNLQ NQQIYGALFV LRILSRKYEF KSDEERTPVS RIVEETFPQL
LTIFNGLIQI PNPSLEIAEL MKLICKIFWS SIYLELPRQL FDLNVFNAWM VLFLSVSERP
VPVEGQPMDP ELRKSWGWWK VKKWTVHILN RLYSRFGDPK LQSPENKPFA QMFQKNYAGR
ILEGHLNFLN TIRVGGYLPD RVINLLLQYL SNSISKNSMY KLLLPRLDVL LFEIVFPLMC
FNDNDQKLWE EDPHEYVRKG YNIIEDLYSP RTASMDFVNE LVRKRGKENL PKFVKFVVEI
FLSYEKATVE EKPYRQKDGA MLAVGALCDK LKQTDPYKSQ LELMLVQHIF PDFNSPVGHL
RAKAAWVAGQ YAHINFSDQN NFRKALHSVV SGLRDPDLPV RVDSVFALRS FVEACKDLNE
IRPILPQLLD EFFKLMNEVE NEDLVFTLET IVDKFGEEMA PFAFGLCQNL AAAFWRCLNT
SEANDDSDDM GALAAVGCLR AISTILESVS SLPQLFVEIE PTILPIMQKM LTTDGQEVFE
EVLEIASYMT FYSPSISLDI WSLWPLMVEA LVDWGIDFFP NILVPMDNFI SRGTAHFLTC
KEPDYQQSLY NVLSTLMTDR NIEDSEIESA PKLIEVVFQN CKGQVDQWVE PYLRLTVDRL
QRAETSYVKS LLIQVVANML YYNPGLTLGV LHNTGLASKV FDLWFQMLQQ KRKSGLPANF
KREHDKKVCC LGLTSLLALP GGQFPDEALQ RVFRATLDLL VAYKNQLAEA AKETEVDYEE
EMNGLQSSDD DYDDDGSDGE MDDTEEGDEA QSVKLQKLAA QAKAFHYDDD DDDDSDDDFS
DEDEFQSPID EVDAFVFFVD AIRVMQASDA QRFQNLNQSL DFTYQAIANG IAQHAELRRV
EIEKEKQKKL AAASTPVTAL


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