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Inclusion membrane protein G

 INCG_CHLTR              Reviewed;         167 AA.
O84120; Q9RPP8;
04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
31-JAN-2018, entry version 81.
RecName: Full=Inclusion membrane protein G;
Name=incG; OrderedLocusNames=CT_118;
Chlamydia trachomatis (strain D/UW-3/Cx).
Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
Chlamydia/Chlamydophila group; Chlamydia.
NCBI_TaxID=272561;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, AND FUNCTION.
STRAIN=L2/434/Bu;
PubMed=10447885; DOI=10.1046/j.1365-2958.1999.01523.x;
Scidmore-Carlson M.A., Shaw E.I., Dooley C.A., Fischer E.R.,
Hackstadt T.;
"Identification and characterization of a Chlamydia trachomatis early
operon encoding four novel inclusion membrane proteins.";
Mol. Microbiol. 33:753-765(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=D/UW-3/Cx;
PubMed=9784136; DOI=10.1126/science.282.5389.754;
Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V.,
Davis R.W.;
"Genome sequence of an obligate intracellular pathogen of humans:
Chlamydia trachomatis.";
Science 282:754-759(1998).
[3]
PHOSPHORYLATION AT SER-166, INTERACTION WITH 14-3-3 BETA, AND
MUTAGENESIS OF SER-164 AND SER-166.
PubMed=11260479; DOI=10.1046/j.1365-2958.2001.02355.x;
Scidmore M.A., Hackstadt T.;
"Mammalian 14-3-3beta associates with the Chlamydia trachomatis
inclusion membrane via its interaction with IncG.";
Mol. Microbiol. 39:1638-1650(2001).
[4]
INTERACTION WITH PKN1.
STRAIN=L2;
PubMed=14500499; DOI=10.1128/IAI.71.10.5772-5784.2003;
Verma A., Maurelli A.T.;
"Identification of two eukaryote-like serine/threonine kinases encoded
by Chlamydia trachomatis serovar L2 and characterization of
interacting partners of Pkn1.";
Infect. Immun. 71:5772-5784(2003).
-!- FUNCTION: Inclusion membrane protein probably involved in early
modification events of the chlamydial inclusion. Binds to the host
cell 14-3-3 beta. The binding is associated with phosphorylation
of Ser-166. The function of this interaction in chlamydiae remains
unknown. {ECO:0000269|PubMed:10447885}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10447885}. Host
cell membrane {ECO:0000305}; Multi-pass membrane protein
{ECO:0000305}. Note=Secreted, probably via type III secretion
system. Localized to the inclusion membrane.
-!- PTM: Phosphorylated by chlamydial kinase pnk1.
{ECO:0000269|PubMed:11260479}.
-!- MISCELLANEOUS: Cotranscribed with incD, incE and incF within 2
hours after internalization.
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EMBL; AF151374; AAD43977.1; -; Genomic_DNA.
EMBL; AE001273; AAC67709.1; -; Genomic_DNA.
PIR; B71553; B71553.
RefSeq; NP_219621.1; NC_000117.1.
RefSeq; WP_009871465.1; NC_000117.1.
SMR; O84120; -.
iPTMnet; O84120; -.
EnsemblBacteria; AAC67709; AAC67709; CT_118.
GeneID; 884170; -.
KEGG; ctr:CT_118; -.
PATRIC; fig|272561.5.peg.130; -.
OMA; APESIPM; -.
Proteomes; UP000000431; Chromosome.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
1: Evidence at protein level;
Complete proteome; Host cell membrane; Host membrane; Membrane;
Phosphoprotein; Reference proteome; Secreted; Transmembrane;
Transmembrane helix; Virulence.
CHAIN 1 167 Inclusion membrane protein G.
/FTId=PRO_0000084204.
TRANSMEM 37 57 Helical. {ECO:0000255}.
TRANSMEM 63 83 Helical. {ECO:0000255}.
MOTIF 161 166 Phosphorylation-dependent binding motif.
SITE 166 166 Interaction with 14-3-3 beta.
MOD_RES 166 166 Phosphoserine.
{ECO:0000269|PubMed:11260479}.
VARIANT 33 33 A -> V (in strain: L2/434/Bu).
VARIANT 77 77 F -> C (in strain: L2/434/Bu).
VARIANT 79 79 C -> Y (in strain: L2/434/Bu).
VARIANT 87 87 N -> S (in strain: L2/434/Bu).
VARIANT 135 136 FG -> LR (in strain: L2/434/Bu).
VARIANT 141 141 L -> F (in strain: L2/434/Bu).
VARIANT 165 165 H -> R (in strain: L2/434/Bu).
MUTAGEN 164 164 S->A: 2 to 3-fold decrease in binding to
14-3-3 beta.
{ECO:0000269|PubMed:11260479}.
MUTAGEN 166 166 S->A: Loss of binding to 14-3-3 beta.
{ECO:0000269|PubMed:11260479}.
SEQUENCE 167 AA; 17405 MW; CB720C45F3A713E4 CRC64;
MICCDKVLSS VQSMPVIDKC SVTKCLQTAK QAAVLALSLF AVFASGSLSI LSAAVLFSGT
AAVLPYLLIL TTALLGFVCA VIVLLRNLSA VVQSCKKRSP EEIEGAARPS DQQESGGRLS
EESASPQASP TSSTFGLESA LRSIGDSVSG AFDDINKDNS RSRSHSF


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