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Inhibin beta A chain (Activin beta-A chain)

 INHBA_RAT               Reviewed;         424 AA.
P18331;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 1.
22-NOV-2017, entry version 136.
RecName: Full=Inhibin beta A chain;
AltName: Full=Activin beta-A chain;
Flags: Precursor;
Name=Inhba;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3153478; DOI=10.1210/mend-1-8-561;
Woodruff T.K., Meunier H., Jones P.B.C., Hsueh A.J.W., Mayo K.E.;
"Rat inhibin: molecular cloning of alpha- and beta-subunit
complementary deoxyribonucleic acids and expression in the ovary.";
Mol. Endocrinol. 1:561-568(1987).
-!- FUNCTION: Inhibins and activins inhibit and activate,
respectively, the secretion of follitropin by the pituitary gland.
Inhibins/activins are involved in regulating a number of diverse
functions such as hypothalamic and pituitary hormone secretion,
gonadal hormone secretion, germ cell development and maturation,
erythroid differentiation, insulin secretion, nerve cell survival,
embryonic axial development or bone growth, depending on their
subunit composition. Inhibins appear to oppose the functions of
activins.
-!- SUBUNIT: Dimeric, linked by one or more disulfide bonds. Inhibin A
is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and
beta-B. Activin A is a homodimer of beta-A. Activin B is a
homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.
Interacts with FST and FSTL3 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; M37482; AAA41436.1; -; mRNA.
PIR; B40905; B40905.
RefSeq; NP_058824.1; NM_017128.2.
RefSeq; XP_006254063.1; XM_006254001.3.
RefSeq; XP_008769934.1; XM_008771712.2.
RefSeq; XP_008769935.1; XM_008771713.2.
RefSeq; XP_008769936.1; XM_008771714.2.
RefSeq; XP_008769937.1; XM_008771715.2.
RefSeq; XP_008769938.1; XM_008771716.2.
UniGene; Rn.9874; -.
ProteinModelPortal; P18331; -.
SMR; P18331; -.
STRING; 10116.ENSRNOP00000019272; -.
iPTMnet; P18331; -.
PhosphoSitePlus; P18331; -.
PaxDb; P18331; -.
PRIDE; P18331; -.
Ensembl; ENSRNOT00000019272; ENSRNOP00000019272; ENSRNOG00000014320.
GeneID; 29200; -.
KEGG; rno:29200; -.
UCSC; RGD:62074; rat.
CTD; 3624; -.
RGD; 62074; Inhba.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00760000119112; -.
HOGENOM; HOG000220890; -.
HOVERGEN; HBG105613; -.
InParanoid; P18331; -.
KO; K04667; -.
OMA; LRPHPKH; -.
OrthoDB; EOG091G09LW; -.
PhylomeDB; P18331; -.
TreeFam; TF351791; -.
Reactome; R-RNO-1502540; Signaling by Activin.
Reactome; R-RNO-209822; Glycoprotein hormones.
Reactome; R-RNO-2473224; Antagonism of Activin by Follistatin.
PRO; PR:P18331; -.
Proteomes; UP000002494; Chromosome 17.
Bgee; ENSRNOG00000014320; -.
Genevisible; P18331; RN.
GO; GO:0043509; C:activin A complex; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0043512; C:inhibin A complex; IDA:RGD.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0034711; F:inhibin binding; IPI:RGD.
GO; GO:0017046; F:peptide hormone binding; ISO:RGD.
GO; GO:0046982; F:protein heterodimerization activity; IDA:RGD.
GO; GO:0005102; F:receptor binding; ISO:RGD.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0070699; F:type II activin receptor binding; ISO:RGD.
GO; GO:0032924; P:activin receptor signaling pathway; ISS:BHF-UCL.
GO; GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0071397; P:cellular response to cholesterol; IDA:UniProtKB.
GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IDA:UniProtKB.
GO; GO:0035987; P:endodermal cell differentiation; ISO:RGD.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:0061029; P:eyelid development in camera-type eye; ISS:UniProtKB.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0097154; P:GABAergic neuron differentiation; ISO:RGD.
GO; GO:0001942; P:hair follicle development; ISS:UniProtKB.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0042541; P:hemoglobin biosynthetic process; ISS:UniProtKB.
GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
GO; GO:0001707; P:mesoderm formation; ISO:RGD.
GO; GO:0048333; P:mesodermal cell differentiation; ISO:RGD.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0051799; P:negative regulation of hair follicle development; IEA:Ensembl.
GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
GO; GO:0060021; P:palate development; ISS:UniProtKB.
GO; GO:0032270; P:positive regulation of cellular protein metabolic process; ISO:RGD.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; ISS:UniProtKB.
GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0060279; P:positive regulation of ovulation; ISS:UniProtKB.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0042701; P:progesterone secretion; ISS:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0046880; P:regulation of follicle-stimulating hormone secretion; ISS:UniProtKB.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; ISS:UniProtKB.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
GO; GO:0021773; P:striatal medium spiny neuron differentiation; ISO:RGD.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR000491; Inhibin_betaA.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PRINTS; PR00670; INHIBINBA.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Glycoprotein; Growth factor; Hormone; Reference proteome; Secreted;
Signal.
SIGNAL 1 20 {ECO:0000250}.
PROPEP 21 308
/FTId=PRO_0000033714.
CHAIN 309 424 Inhibin beta A chain.
/FTId=PRO_0000033715.
CARBOHYD 165 165 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 312 320 {ECO:0000250}.
DISULFID 319 389 {ECO:0000250}.
DISULFID 348 421 {ECO:0000250}.
DISULFID 352 423 {ECO:0000250}.
DISULFID 388 388 Interchain. {ECO:0000250}.
SEQUENCE 424 AA; 47406 MW; B2DAF7917FA50984 CRC64;
MPLLWLRGFL LASCWIIVRS SPTPGSEGHG AAPDCPSCAL ATLPKDGPNS QPEMVEAVKK
HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT
SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRTK VTIRLFQQQK
HPQGSLDMGD EAEEMGLKGE RSELLLSEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDV
RIACEQCQES GASLVLLGKK KKKEVDGDGK KKDGSDGGLE EEKEQSHRPF LMLQARQSED
HPHRRRRRGL ECDGKVNICC KKQFFVSFKD IGWNDWIIAP SGYHANYCEG ECPSHIAGTS
GSSLSFHSTV INHYRMRGHS PFANLKSCCV PTKLRPMSML YYDDGQNIIK KDIQNMIVEE
CGCS


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Catalog number Product name Quantity
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RF0029-100 Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2, rHuman Activin B Active 100ug
RF0029-5 rHuman Activin B Active; Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 5ug
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RF0029-100 rHuman Activin B Active; Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 100ug
RF0029-25 rHuman Activin B Active; Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 25ug
RF0029-25 Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2, rHuman Activin B Active 25ug
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PNb-015 Activin-B Human Host: Nicotiana benthamiana INHBBActivin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 25
PNb-014 Activin-B Human Host: Nicotiana benthamiana INHBBActivin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 10
PNb-002-I Activin-A (inactive!) Human Host: Nicotiana benthamiana INHBA; EDF; FRP Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein 10
101-M204 Activin-C, Host: Mouse, Species: Anti-Human, Synonyms: Inhbc; activin beta-C chain; inhibin beta C chain 100 ug
PNb-001 Activin-A Human Host: Nicotiana benthamiana INHBA; EDF; FRP Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein 5
PNb-002 Activin-A Human Host: Nicotiana benthamiana INHBA; EDF; FRP Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein 10
PNb-011 Activin-A Human Host: Nicotiana benthamiana INHBA; EDF; FRP Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein 50
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RF0028-10 Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2, rHuman Activin B 10ug
RF0028-5 Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2, rHuman Activin B 5ug
RF0028-10 rHuman Activin B; Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 10ug
RF0028-100 rHuman Activin B; Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2 100ug
RF0010-5 Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein, rHuman Activin A Active 5ug
RF0010-10 Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein, rHuman Activin A Active 10ug
RF0010-50 Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein, rHuman Activin A Active 50ug


 

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