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Inhibin beta A chain (Activin beta-A chain)

 INHBA_HORSE             Reviewed;         426 AA.
P55102;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
23-MAY-2018, entry version 101.
RecName: Full=Inhibin beta A chain;
AltName: Full=Activin beta-A chain;
Flags: Precursor;
Name=INHBA;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
PubMed=7548399; DOI=10.1292/jvms.57.469;
Yoshida S., Yamanouchi K., Hasegawa T., Ikeda A., Suzuki M., Chang K.,
Matsuyama S., Nishihara M., Takahashi M.;
"Molecular cloning of cDNA for equine ovarian inhibin/activin beta A
subunit.";
J. Vet. Med. Sci. 57:469-473(1995).
-!- FUNCTION: Inhibins and activins inhibit and activate,
respectively, the secretion of follitropin by the pituitary gland.
Inhibins/activins are involved in regulating a number of diverse
functions such as hypothalamic and pituitary hormone secretion,
gonadal hormone secretion, germ cell development and maturation,
erythroid differentiation, insulin secretion, nerve cell survival,
embryonic axial development or bone growth, depending on their
subunit composition. Inhibins appear to oppose the functions of
activins.
-!- SUBUNIT: Dimeric, linked by one or more disulfide bonds. Inhibin A
is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and
beta-B. Activin A is a homodimer of beta-A. Activin B is a
homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.
Interacts with FST and FSTL3 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; D50326; BAA08862.1; -; mRNA.
RefSeq; NP_001075378.1; NM_001081909.1.
UniGene; Eca.429; -.
ProteinModelPortal; P55102; -.
SMR; P55102; -.
STRING; 9796.ENSECAP00000019902; -.
PaxDb; P55102; -.
PRIDE; P55102; -.
GeneID; 100034076; -.
KEGG; ecb:100034076; -.
CTD; 3624; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
HOGENOM; HOG000220890; -.
HOVERGEN; HBG105613; -.
InParanoid; P55102; -.
KO; K04667; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0043509; C:activin A complex; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0043512; C:inhibin A complex; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0032924; P:activin receptor signaling pathway; ISS:BHF-UCL.
GO; GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0061029; P:eyelid development in camera-type eye; ISS:UniProtKB.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0001942; P:hair follicle development; ISS:UniProtKB.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISS:UniProtKB.
GO; GO:0042541; P:hemoglobin biosynthetic process; ISS:UniProtKB.
GO; GO:0008584; P:male gonad development; ISS:UniProtKB.
GO; GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0042476; P:odontogenesis; ISS:UniProtKB.
GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; ISS:UniProtKB.
GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISS:UniProtKB.
GO; GO:0060279; P:positive regulation of ovulation; ISS:UniProtKB.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0042701; P:progesterone secretion; ISS:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0046880; P:regulation of follicle-stimulating hormone secretion; ISS:UniProtKB.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; ISS:UniProtKB.
GO; GO:0060021; P:roof of mouth development; ISS:UniProtKB.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR000491; Inhibin_betaA.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PRINTS; PR00670; INHIBINBA.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Glycoprotein; Growth factor; Hormone; Reference proteome; Secreted;
Signal.
SIGNAL 1 20 {ECO:0000250}.
PROPEP 21 310
/FTId=PRO_0000033706.
CHAIN 311 426 Inhibin beta A chain.
/FTId=PRO_0000033707.
CARBOHYD 165 165 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 314 322 {ECO:0000250}.
DISULFID 321 391 {ECO:0000250}.
DISULFID 350 423 {ECO:0000250}.
DISULFID 354 425 {ECO:0000250}.
DISULFID 390 390 Interchain. {ECO:0000250}.
SEQUENCE 426 AA; 47710 MW; E481060B8368A77D CRC64;
MPLLWLRGFL LASCWIIVKS SPTPGSEGHS AAPNCPSCAL ATLPKDVPNA QPEMVEAVKK
HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY VEIEDDIGRR AEMNELMEQT
SEIITFAESG TARKTLHFEI SKEGSDLSVV ERAEVWLFLK VPKANRTRSK VTIRLLQQQK
HPQGSSDTRE EAEEADLMEE RSEQLISEKV VDARKSTWHI FPVSSSIQRL LDQGKSSLDI
RIACDQCHET GASLVLLGKK KKKEEEGEGK KKDGGEAGAG VDEEKEQSHR PFLMLQARQS
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG
TSGSSLSFHS TVINQYRLRG HNPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV
EECGCS


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RF0028-5 Activin beta-B chain, Inhibin beta B chain precursor; Inhibin, beta-2, rHuman Activin B 5ug
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