Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Inhibitor of nuclear factor kappa-B kinase subunit alpha (I kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)

 IKKA_DANRE              Reviewed;         758 AA.
Q4G3H4; Q7ZTU1;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
30-AUG-2005, sequence version 1.
12-SEP-2018, entry version 81.
RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit alpha;
Short=I kappa-B kinase alpha;
Short=IKK-A;
Short=IKK-alpha;
Short=IkBKA;
Short=IkappaB kinase;
EC=2.7.11.10;
AltName: Full=Conserved helix-loop-helix ubiquitous kinase;
AltName: Full=I-kappa-B kinase 1;
Short=IKK1;
AltName: Full=Nuclear factor NF-kappa-B inhibitor kinase alpha;
Short=NFKBIKA;
Name=chuk; Synonyms=ikk1; ORFNames=zgc:56539;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND INTERACTION WITH
IKBKG.
PubMed=16051172; DOI=10.1016/j.cub.2005.06.023;
Correa R.G., Matsui T., Tergaonkar V., Rodriguez-Esteban C.,
Izpisua-Belmonte J.C., Verma I.M.;
"Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity.";
Curr. Biol. 15:1291-1295(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=SJD;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Phosphorylates inhibitors of NF-kappa-B thus leading to
the dissociation of the inhibitor/NF-kappa-B complex and
ultimately the degradation of the inhibitor. Phosphorylates 'Ser-
10' of histone H3 at NF-kappa-B-regulated promoters during
inflammatory responses triggered by cytokines.
{ECO:0000250|UniProtKB:O15111}.
-!- CATALYTIC ACTIVITY: ATP + [I-kappa-B protein] = ADP + [I-kappa-B
phosphoprotein].
-!- ACTIVITY REGULATION: Activated when phosphorylated and inactivated
when dephosphorylated. {ECO:0000250}.
-!- SUBUNIT: Directly interacts with ikbkg/nemo.
{ECO:0000269|PubMed:16051172}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}. Note=Shuttles between the cytoplasm and the
nucleus. {ECO:0000250}.
-!- DEVELOPMENTAL STAGE: Abundantly expressed from the blastula period
through early gastrulation. During early somitogenesis,
transcripts are dorsally localized at the level of the segmental
plate and the presumptive notochord. At the 18-somite stage,
expression becomes largely detectable throughout the somitic
tissue At late embryonic stages, expression is particularly
evident in the tectum, cerebellum, hindbrain region, and eyes.
After hatching, transcripts can also be detected in the myotomes
and pectoral fins. {ECO:0000269|PubMed:16051172}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. I-kappa-B kinase subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00159}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AY735397; AAW68010.1; -; mRNA.
EMBL; BC051614; AAH51614.1; -; mRNA.
RefSeq; NP_956611.1; NM_200317.1.
UniGene; Dr.14012; -.
ProteinModelPortal; Q4G3H4; -.
SMR; Q4G3H4; -.
STRING; 7955.ENSDARP00000013115; -.
PaxDb; Q4G3H4; -.
PRIDE; Q4G3H4; -.
GeneID; 393287; -.
KEGG; dre:393287; -.
CTD; 1147; -.
ZFIN; ZDB-GENE-040426-1069; chuk.
eggNOG; KOG4250; Eukaryota.
eggNOG; ENOG410XRMU; LUCA.
HOGENOM; HOG000038048; -.
HOVERGEN; HBG018241; -.
InParanoid; Q4G3H4; -.
KO; K04467; -.
PhylomeDB; Q4G3H4; -.
PRO; PR:Q4G3H4; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0008385; C:IkappaB kinase complex; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
GO; GO:0007417; P:central nervous system development; IMP:ZFIN.
GO; GO:0055113; P:epiboly involved in gastrulation with mouth forming second; IMP:ZFIN.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IDA:ZFIN.
GO; GO:0007252; P:I-kappaB phosphorylation; IEA:GOC.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:ZFIN.
GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ZFIN.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0001757; P:somite specification; IMP:ZFIN.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IBA:GO_Central.
InterPro; IPR022007; IKKbetaNEMObind.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF12179; IKKbetaNEMObind; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM01239; IKKbetaNEMObind; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
Nucleus; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 758 Inhibitor of nuclear factor kappa-B
kinase subunit alpha.
/FTId=PRO_0000268827.
DOMAIN 15 301 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 21 29 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 456 477 Leucine-zipper.
REGION 741 746 NEMO-binding. {ECO:0000250}.
ACT_SITE 145 145 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 44 44 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
CONFLICT 61 61 G -> E (in Ref. 1; AAW68010).
{ECO:0000305}.
CONFLICT 363 363 S -> L (in Ref. 1; AAW68010).
{ECO:0000305}.
CONFLICT 438 438 L -> P (in Ref. 1; AAW68010).
{ECO:0000305}.
CONFLICT 617 617 L -> P (in Ref. 1; AAW68010).
{ECO:0000305}.
CONFLICT 756 756 P -> A (in Ref. 1; AAW68010).
{ECO:0000305}.
SEQUENCE 758 AA; 87147 MW; 9E3355AEAE5EE7F7 CRC64;
MEKPPFRQNQ VCGSWVMKER LGTGGFGHVY LYQNQETSEK IAVKLCRLEL NSKNKDRWSR
GIQIMKKLKH LNVVTAKDVP EEMMHIALND LPLLAMEYCS KGDLRKLLSK PENCCGLKES
EVLSLLNDVG SGIQYLHENK IIHRDLKPEN IVLQEINGKL VHKIIDLGYA KDLDQGSLCT
SFVGTLQYLA PELFEGKSYT VTVDFWSFGT MIFECCCGFR PFLHNLQPVQ WTSKVRNKGP
KDIMAVEDMN GEVRFSTHLP YPNNLSRTLL EPLEGLLQLM LKWDPVQRGL GLNTDSKQPQ
CFVLLDQILS MKVVHILNMT TTQVHSFLLS PDEGLHSLQQ RIENETKIEL LNQDLLQETG
VMSDPRKPAA QCVLDGVRGW DSYIVYLFDK SLTKYMGPLT ARTLPESVNF IVRETKTQLP
LSTLKKVWGE AVSYICGLRE DYSRLFQGQR AAMLSLLRFN TNLTRYKNMM FSFSQQLKAK
LDFFKTSIQY DLEKYSDQMQ YGISSEKMLK AWHENEERAA AFAQVAEIGH LDEEIMALHS
EIVELQRSPY ARRQGDVMEQ LQEKAIELYK QLKAKCKMPD PQHGYSDSSE MVKVIVQTVQ
NQDRVLRDLY AHLSKILLSK QKIIDLFPKI ERTLECIKEA DTTVMQMQIK RQREFWHLLK
IACAQNTTRS SVSQSGEMPS SLSTWNQTQA QCSSRLPMSL QVPHEGDSVN HLLEENQRYL
TQLTSLLQET TEEKSESIMA QDWSWTKYES LVAKSPRL


Related products :

Catalog number Product name Quantity
18-661-15055 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.1 mg
18-661-15056 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.1 mg
15-288-21170 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.05 mg
18-661-15038 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.1 mg
15-288-21170 Inhibitor of nuclear factor kappa-B kinase alpha subunit - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitou 0.1 mg
18-785-210223 IKK -alpha (Ab-23) - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B in 0.1 mg
18-785-210223 IKK -alpha (Ab-23) - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-kappa-B in 0.05 mg
18-785-210222 IKK -alpha (Phospho-Thr23) - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-ka 0.05 mg
18-785-210222 IKK -alpha (Phospho-Thr23) - EC 2.7.11.10; I kappa-B kinase alpha; IkBKA; IKK-alpha; IKK-A; IkappaB kinase; I-kappa-B kinase 1; IKK1; Conserved helix-loop-helix ubiquitous kinase; Nuclear factor NF-ka 0.1 mg
U1953h CLIA Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibito 96T
E1953h ELISA Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibit 96T
U1953b CLIA Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kina 96T
E1953m ELISA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B inhibit 96T
U1953h CLIA kit Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inh 96T
U1953m CLIA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,Mouse,Mus musculus,NFKBIKB,Nuclear factor NF-kappa-B inhibito 96T
E1953h ELISA kit Homo sapiens,Human,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKKB,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B in 96T
E1953r ELISA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta 96T
E1953r ELISA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta,Rat, 96T
U1953r CLIA I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta,Rat,R 96T
U1953r CLIA kit I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,Ikbkb,IKK2,Ikkb,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kinase beta, 96T
U1953b CLIA kit Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor 96T
E1953b ELISA Bos taurus,Bovine,I-kappa-B kinase 2,I-kappa-B-kinase beta,IkBKB,IKBKB,IKK2,IKK-B,IKK-beta,Inhibitor of nuclear factor kappa-B kinase subunit beta,NFKBIKB,Nuclear factor NF-kappa-B inhibitor kin 96T
15-288-21171 Inhibitor of nuclear factor kappa B kinase subunit beta - EC 2.7.11.10; I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIK 0.05 mg
15-288-21171 Inhibitor of nuclear factor kappa B kinase subunit beta - EC 2.7.11.10; I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIK 0.1 mg
18-661-15057 Inhibitor of nuclear factor kappa B kinase subunit beta - EC 2.7.11.10; I-kappa-B-kinase beta; IkBKB; IKK-beta; IKK-B; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIK 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur