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Inner kinetochore subunit fta2 (CENP-P homolog) (Constitutive centromere-associated network protein fta2) (Sim4 complex subunit fta2) (Sim4-mal2-associated protein 2)

 CENPP_SCHPO             Reviewed;         351 AA.
Q9US26;
12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-NOV-2018, entry version 80.
RecName: Full=Inner kinetochore subunit fta2;
AltName: Full=CENP-P homolog;
AltName: Full=Constitutive centromere-associated network protein fta2;
AltName: Full=Sim4 complex subunit fta2;
AltName: Full=Sim4-mal2-associated protein 2;
Name=fta2; Synonyms=sma2; ORFNames=SPAC1783.03;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
FUNCTION, IDENTIFICATION IN THE SIM4 COMPLEX, AND SUBCELLULAR
LOCATION.
PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
"Molecular analysis of kinetochore architecture in fission yeast.";
EMBO J. 24:2919-2930(2005).
[3]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
-!- FUNCTION: Component of the kinetochore, a multiprotein complex
that assembles on centromeric DNA and attaches chromosomes to
spindle microtubules, mediating chromosome segregation and sister
chromatid segregation during meiosis and mitosis. Component of the
inner kinetochore COMA complex, which connects centromere-
associated proteins and the outer kinetochore. COMA interacts with
other inner kinetochore proteins to form the inner kinetochore
constitutive centromere-associated network (CCAN), which serves as
a structural platform for outer kinetochore assembly
(PubMed:16079914). Fta2, fta3 and fta4 associate with the central
core (cnt) and inner repeat (inr) region of the centromere
(PubMed:16079914). {ECO:0000269|PubMed:16079914}.
-!- SUBUNIT: Component of the heterotetrameric kinetochore subcomplex
COMA, which consists of fta2, fta7, mal2 and mis17 (By
similarity). The COMA subcomplex is part of a larger constitutive
centromere-associated network (CCAN) (also known as central
kinetochore Sim4 complex in fission yeast), which is composed of
at least cnl2, cnp3, cnp20, fta1, fta2, fta3, fta4, fta6, fta7,
mal2, mhf1, mhf2, mis6, mis15, mis17, sim4 and wip1
(PubMed:16079914). {ECO:0000250|UniProtKB:Q02732,
ECO:0000269|PubMed:16079914}.
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere,
kinetochore.
-!- SIMILARITY: Belongs to the CENP-P/CTF19 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; CU329670; CAB66166.1; -; Genomic_DNA.
PIR; T50105; T50105.
RefSeq; NP_593658.1; NM_001019090.2.
BioGrid; 278831; 10.
STRING; 4896.SPAC1783.03.1; -.
iPTMnet; Q9US26; -.
PaxDb; Q9US26; -.
PRIDE; Q9US26; -.
EnsemblFungi; SPAC1783.03.1; SPAC1783.03.1:pep; SPAC1783.03.
GeneID; 2542367; -.
KEGG; spo:SPAC1783.03; -.
EuPathDB; FungiDB:SPAC1783.03; -.
PomBase; SPAC1783.03; fta2.
OMA; PNINRPV; -.
OrthoDB; EOG092C47IJ; -.
PRO; PR:Q9US26; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0000941; C:condensed nuclear chromosome inner kinetochore; IDA:PomBase.
GO; GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:PomBase.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
GO; GO:0005634; C:nucleus; HDA:PomBase.
GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IMP:PomBase.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0000070; P:mitotic sister chromatid segregation; IGI:PomBase.
InterPro; IPR025213; Sim4_Fta2.
Pfam; PF13095; FTA2; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Centromere; Chromosome;
Chromosome partition; Complete proteome; Kinetochore; Microtubule;
Mitosis; Nucleus; Reference proteome.
CHAIN 1 351 Inner kinetochore subunit fta2.
/FTId=PRO_0000290638.
SEQUENCE 351 AA; 40505 MW; 45017DB34C0EC3B3 CRC64;
MSGRRYSQIS QQEGSSSSDD SDSQQKKTKR TVAHRSPNTT LNGMPRVDSR ARPNENSGQS
KSSNGRVDTD RKMDLLRKRS NLVHQTLLLE KEVRVRRNAI NQRDDSFLSG FIKSLLEIDS
SVVIYNTENP DNPKTKQVMP SAEPKKHVKL NSSISSIRFT QHEFEAESEK IIHHSLKGDI
EYLPSFKFLL EIKVRTIDYA LLFITYKIPH FARKELSSFS DSAIQCLDIV ALLRAFSLFA
HHYSYRCNTW FYLSKHMKKV ASANMDAQCF YVQNSFYKIT ILYEIKFDDL GFVQPNYCIS
YILKNQNEKI VSITSKLLNQ LDKRFSEFVS LFGFREGSLL LLQALFKPHL G


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