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Inner kinetochore subunit fta4 (Constitutive centromere-associated network protein fta4) (Sim4 complex subunit fta4) (Sim4-mal2-associated protein 4)

 NKP1_SCHPO              Reviewed;         233 AA.
O94716;
12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
28-FEB-2018, entry version 88.
RecName: Full=Inner kinetochore subunit fta4;
AltName: Full=Constitutive centromere-associated network protein fta4;
AltName: Full=Sim4 complex subunit fta4;
AltName: Full=Sim4-mal2-associated protein 4;
Name=fta4; Synonyms=sma4; ORFNames=SPCC1393.04;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
FUNCTION, IDENTIFICATION IN THE SIM4 COMPLEX, AND SUBCELLULAR
LOCATION.
PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
"Molecular analysis of kinetochore architecture in fission yeast.";
EMBO J. 24:2919-2930(2005).
[3]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-189 AND THR-191, AND
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=18257517; DOI=10.1021/pr7006335;
Wilson-Grady J.T., Villen J., Gygi S.P.;
"Phosphoproteome analysis of fission yeast.";
J. Proteome Res. 7:1088-1097(2008).
-!- FUNCTION: Component of the kinetochore, a multiprotein complex
that assembles on centromeric DNA and attaches chromosomes to
spindle microtubules, mediating chromosome segregation and sister
chromatid segregation during meiosis and mitosis. Component of the
inner kinetochore constitutive centromere-associated network
(CCAN), which serves as a structural platform for outer
kinetochore assembly (PubMed:16079914). Fta2, fta3 and fta4
associate with the central core (cnt) and inner repeat (inr)
region of the centromere (PubMed:16079914).
{ECO:0000269|PubMed:16079914}.
-!- SUBUNIT: Component of the inner kinetochore constitutive
centromere-associated network (CCAN) (also known as central
kinetochore Sim4 complex in fission yeast), which is composed of
at least cnl2, cnp3, cnp20, fta1, fta2, fta3, fta4, fta6, fta7,
mal2, mhf1, mhf2, mis6, mis15, mis17, sim4 and wip1.
{ECO:0000269|PubMed:16079914}.
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere,
kinetochore.
-!- SIMILARITY: Belongs to the NKP1 family. {ECO:0000305}.
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EMBL; CU329672; CAB38160.1; -; Genomic_DNA.
PIR; T40952; T40952.
RefSeq; NP_587962.1; NM_001022953.2.
BioGrid; 275303; 8.
STRING; 4896.SPCC1393.04.1; -.
iPTMnet; O94716; -.
PaxDb; O94716; -.
PRIDE; O94716; -.
EnsemblFungi; SPCC1393.04.1; SPCC1393.04.1:pep; SPCC1393.04.
GeneID; 2538719; -.
KEGG; spo:SPCC1393.04; -.
EuPathDB; FungiDB:SPCC1393.04; -.
PomBase; SPCC1393.04; fta4.
InParanoid; O94716; -.
OrthoDB; EOG092C42KB; -.
PhylomeDB; O94716; -.
PRO; PR:O94716; -.
Proteomes; UP000002485; Chromosome III.
GO; GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:PomBase.
GO; GO:0005737; C:cytoplasm; HDA:PomBase.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0031511; C:Mis6-Sim4 complex; IDA:PomBase.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0000070; P:mitotic sister chromatid segregation; IC:PomBase.
InterPro; IPR025207; Sim4_Fta4.
PANTHER; PTHR42040; PTHR42040; 1.
Pfam; PF13093; FTA4; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Centromere; Chromosome;
Chromosome partition; Complete proteome; Kinetochore; Microtubule;
Mitosis; Nucleus; Phosphoprotein; Reference proteome.
CHAIN 1 233 Inner kinetochore subunit fta4.
/FTId=PRO_0000290640.
MOD_RES 189 189 Phosphothreonine.
{ECO:0000269|PubMed:18257517}.
MOD_RES 191 191 Phosphothreonine.
{ECO:0000269|PubMed:18257517}.
SEQUENCE 233 AA; 27149 MW; E2983A3D7EB79EB9 CRC64;
MDIYEHKKSF MERQIRLLNR PMRPPKDWKL PLKSGQLSES VVETVFQRLQ LRIQKHAKLN
YSHQATQHVA AQIRKLYEQN SAIEDITFLN PLFYGEIDLS NLDSVKSLPH PWPFQKESRP
VEKDEEQEKF NRLTGELLGL LTTLSELEQE RSELEQIEKM LEPFEDGPSS IHTNMWKKNP
ELISTLNSTN TMVAKINSLL RGVSFPSLNN DNQEASLEDE IRSQLFEKTI SDD


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