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Inner membrane protein YqjA

 YQJA_ECOLI              Reviewed;         220 AA.
P0AA63; P42614; Q2M9B1;
13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
13-SEP-2005, sequence version 1.
05-JUL-2017, entry version 88.
RecName: Full=Inner membrane protein YqjA;
Name=yqjA; OrderedLocusNames=b3095, JW3066;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-188.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
Mizobuchi K.;
Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
[4]
TOPOLOGY [LARGE SCALE ANALYSIS].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=15919996; DOI=10.1126/science.1109730;
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
"Global topology analysis of the Escherichia coli inner membrane
proteome.";
Science 308:1321-1323(2005).
[5]
INDUCTION.
STRAIN=K12;
PubMed=16861804; DOI=10.1271/bbb.60024;
Yamamoto K., Ishihama A.;
"Characterization of copper-inducible promoters regulated by CpxA/CpxR
in Escherichia coli.";
Biosci. Biotechnol. Biochem. 70:1688-1695(2006).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=18456815; DOI=10.1128/JB.00414-08;
Thompkins K., Chattopadhyay B., Xiao Y., Henk M.C., Doerrler W.T.;
"Temperature sensitivity and cell division defects in an Escherichia
coli strain with mutations in yghB and yqjA, encoding related and
conserved inner membrane proteins.";
J. Bacteriol. 190:4489-4500(2008).
[7]
FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=19880597; DOI=10.1128/JB.00716-09;
Sikdar R., Doerrler W.T.;
"Inefficient Tat-dependent export of periplasmic amidases in an
Escherichia coli strain with mutations in two DedA family genes.";
J. Bacteriol. 192:807-818(2010).
[8]
FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLU-39 AND ASP-51.
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=24277026; DOI=10.1128/AAC.02238-13;
Kumar S., Doerrler W.T.;
"Members of the conserved DedA family are likely membrane transporters
and are required for drug resistance in Escherichia coli.";
Antimicrob. Agents Chemother. 58:923-930(2014).
-!- FUNCTION: May be a membrane transporter required for proton motive
force (PMF)-dependent drug efflux. Required, with YghB, for the
proper export of certain periplasmic amidases and, possibly, other
Tat substrates. May play a role in determining membrane lipid
composition. {ECO:0000269|PubMed:18456815,
ECO:0000269|PubMed:19880597, ECO:0000269|PubMed:24277026}.
-!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
protein.
-!- INDUCTION: Regulated by the CpxA/CpxR two-component system.
{ECO:0000269|PubMed:16861804}.
-!- DISRUPTION PHENOTYPE: Double mutants lacking both yghB and yqjA
show incomplete cell division, temperature sensitivity and altered
phospholipid levels. They are also hypersensitive to several
compounds known to be exported by other drug efflux proteins,
including ethidium bromide, methyl viologen, acriflavine and beta-
lactam antibiotics. Expression of either yghB or yqjA can restore
the wild-type phenotype, suggesting that these proteins have
redundant functions. Both individual null mutant strains grow
normally at all temperatures. {ECO:0000269|PubMed:18456815,
ECO:0000269|PubMed:19880597, ECO:0000269|PubMed:24277026}.
-!- SIMILARITY: Belongs to the DedA family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U18997; AAA57899.1; -; Genomic_DNA.
EMBL; U00096; AAC76130.1; -; Genomic_DNA.
EMBL; AP009048; BAE77145.1; -; Genomic_DNA.
EMBL; D13328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PIR; D65098; D65098.
RefSeq; NP_417566.1; NC_000913.3.
RefSeq; WP_000422149.1; NZ_LN832404.1.
ProteinModelPortal; P0AA63; -.
BioGrid; 4262411; 70.
STRING; 316385.ECDH10B_3271; -.
TCDB; 9.B.27.2.2; the deda or ydjx-z (deda) family.
PaxDb; P0AA63; -.
PRIDE; P0AA63; -.
EnsemblBacteria; AAC76130; AAC76130; b3095.
EnsemblBacteria; BAE77145; BAE77145; BAE77145.
GeneID; 947643; -.
KEGG; ecj:JW3066; -.
KEGG; eco:b3095; -.
PATRIC; fig|1411691.4.peg.3633; -.
EchoBASE; EB2596; -.
EcoGene; EG12740; yqjA.
eggNOG; ENOG4106W5V; Bacteria.
eggNOG; COG0586; LUCA.
HOGENOM; HOG000105367; -.
InParanoid; P0AA63; -.
PhylomeDB; P0AA63; -.
BioCyc; EcoCyc:G7609-MONOMER; -.
PRO; PR:P0AA63; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
GO; GO:0022857; F:transmembrane transporter activity; IMP:EcoCyc.
GO; GO:0043093; P:FtsZ-dependent cytokinesis; IGI:EcoCyc.
GO; GO:0055085; P:transmembrane transport; IMP:EcoCyc.
InterPro; IPR032818; DedA.
InterPro; IPR032816; SNARE_assoc.
PANTHER; PTHR30353; PTHR30353; 1.
Pfam; PF09335; SNARE_assoc; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Complete proteome; Membrane;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 220 Inner membrane protein YqjA.
/FTId=PRO_0000161417.
TOPO_DOM 1 27 Periplasmic. {ECO:0000255}.
TRANSMEM 28 48 Helical. {ECO:0000255}.
TOPO_DOM 49 52 Cytoplasmic. {ECO:0000255}.
TRANSMEM 53 73 Helical. {ECO:0000255}.
TRANSMEM 74 94 Helical. {ECO:0000255}.
TOPO_DOM 95 154 Cytoplasmic. {ECO:0000255}.
TRANSMEM 155 175 Helical. {ECO:0000255}.
TOPO_DOM 176 191 Periplasmic. {ECO:0000255}.
TRANSMEM 192 212 Helical. {ECO:0000255}.
TOPO_DOM 213 220 Cytoplasmic. {ECO:0000255}.
MUTAGEN 39 39 E->A,Q: Abolishes the ability to restore
growth, cell division or drug resistance
in double mutant.
{ECO:0000269|PubMed:24277026}.
MUTAGEN 51 51 D->A,N: Abolishes the ability to restore
growth, cell division or drug resistance
in double mutant.
{ECO:0000269|PubMed:24277026}.
SEQUENCE 220 AA; 24585 MW; 07EE88184D420201 CRC64;
MELLTQLLQA LWAQDFETLA NPSMIGMLYF VLFVILFLEN GLLPAAFLPG DSLLVLVGVL
IAKGAMGYPQ TILLLTVAAS LGCWVSYIQG RWLGNTRTVQ NWLSHLPAHY HQRAHHLFHK
HGLSALLIGR FIAFVRTLLP TIAGLSGLNN ARFQFFNWMS GLLWVLILTT LGYMLGKTPV
FLKYEDQLMS CLMLLPVVLL VFGLAGSLVV LWKKKYGNRG


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