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Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)

 ITPA_PICST              Reviewed;         194 AA.
A3LVK6;
19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
03-APR-2007, sequence version 1.
23-MAY-2018, entry version 70.
RecName: Full=Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=ITPase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=Inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
EC=3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=NTPase {ECO:0000255|HAMAP-Rule:MF_03148};
Name=HAM1 {ECO:0000255|HAMAP-Rule:MF_03148}; ORFNames=PICST_72696;
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 /
NRRL Y-11545) (Yeast) (Pichia stipitis).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Scheffersomyces.
NCBI_TaxID=322104;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
PubMed=17334359; DOI=10.1038/nbt1290;
Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
Passoth V., Richardson P.M.;
"Genome sequence of the lignocellulose-bioconverting and xylose-
fermenting yeast Pichia stipitis.";
Nat. Biotechnol. 25:319-326(2007).
-!- FUNCTION: Pyrophosphatase that hydrolyzes non-canonical purine
nucleotides such as inosine triphosphate (ITP), deoxyinosine
triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their
respective monophosphate derivatives. The enzyme does not
distinguish between the deoxy- and ribose forms. Probably excludes
non-canonical purines from RNA and DNA precursor pools, thus
preventing their incorporation into RNA and DNA and avoiding
chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a
nucleotide + diphosphate. {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_03148};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000255|HAMAP-Rule:MF_03148};
Note=Binds 1 divalent metal cation per subunit; can use either
Mg(2+) or Mn(2+). {ECO:0000255|HAMAP-Rule:MF_03148};
-!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148}.
Nucleus {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- SIMILARITY: Belongs to the HAM1 NTPase family. {ECO:0000255|HAMAP-
Rule:MF_03148}.
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EMBL; CP000499; ABN67137.1; -; Genomic_DNA.
RefSeq; XP_001385166.1; XM_001385129.1.
ProteinModelPortal; A3LVK6; -.
SMR; A3LVK6; -.
STRING; 322104.XP_001385166.1; -.
EnsemblFungi; ABN67137; ABN67137; PICST_72696.
GeneID; 4839424; -.
KEGG; pic:PICST_72696; -.
eggNOG; KOG3222; Eukaryota.
eggNOG; COG0127; LUCA.
HOGENOM; HOG000293320; -.
InParanoid; A3LVK6; -.
KO; K01519; -.
OMA; YDPIFQP; -.
OrthoDB; EOG092C523G; -.
Proteomes; UP000002258; Chromosome 5.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0035529; F:NADH pyrophosphatase activity; IEA:UniProtKB-EC.
GO; GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IEA:InterPro.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:InterPro.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
CDD; cd00515; HAM1; 1.
Gene3D; 3.90.950.10; -; 1.
HAMAP; MF_03148; HAM1_NTPase; 1.
InterPro; IPR002637; Ham1p-like.
InterPro; IPR027502; ITPase.
InterPro; IPR029001; ITPase-like_fam.
PANTHER; PTHR11067; PTHR11067; 1.
Pfam; PF01725; Ham1p_like; 1.
SUPFAM; SSF52972; SSF52972; 1.
TIGRFAMs; TIGR00042; TIGR00042; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese;
Metal-binding; Nucleotide metabolism; Nucleotide-binding; Nucleus;
Reference proteome.
CHAIN 1 194 Inosine triphosphate pyrophosphatase.
/FTId=PRO_0000413149.
REGION 8 13 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 75 76 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 151 154 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 179 180 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
METAL 47 47 Magnesium or manganese.
{ECO:0000255|HAMAP-Rule:MF_03148}.
METAL 75 75 Magnesium or manganese.
{ECO:0000255|HAMAP-Rule:MF_03148}.
BINDING 59 59 Substrate. {ECO:0000255|HAMAP-
Rule:MF_03148}.
BINDING 174 174 Substrate. {ECO:0000255|HAMAP-
Rule:MF_03148}.
SEQUENCE 194 AA; 21181 MW; 37508E302F527996 CRC64;
MSTVTFVTGN ANKLKEVIAI LSGSQSEGGE SKVGNFTIVN KSLDLDELQG SIEEVTIHKA
KSAAEILGGP VLVEDTCLGF TAFNDLPGPY IKWFVKSVGL QGLVDMLYKF EDKSAKAICT
FGYCEGPGKP VQLFQGITKG SIVESRGPTN FGWDSIFQPD GFDKTYAELD KEIKNSISHR
FRALDKLRDF LVSQ


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