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Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)

 G8ZW58_TORDC            Unreviewed;       194 AA.
G8ZW58;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
28-MAR-2018, entry version 39.
RecName: Full=Inosine triphosphate pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
Short=ITPase {ECO:0000256|HAMAP-Rule:MF_03148};
Short=Inosine triphosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
EC=3.6.1.9 {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Non-canonical purine NTP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Non-standard purine NTP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate diphosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
Short=NTPase {ECO:0000256|HAMAP-Rule:MF_03148};
Name=TDEL0F00410 {ECO:0000313|EMBL:CCE92852.1};
Synonyms=HAM1 {ECO:0000256|HAMAP-Rule:MF_03148};
ORFNames=TDEL_0F00410 {ECO:0000313|EMBL:CCE92852.1};
Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 /
NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Torulaspora.
NCBI_TaxID=1076872 {ECO:0000313|Proteomes:UP000005627};
[1] {ECO:0000313|EMBL:CCE92852.1, ECO:0000313|Proteomes:UP000005627}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866
{ECO:0000313|Proteomes:UP000005627};
PubMed=22123960; DOI=10.1073/pnas.1112808108;
Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
Byrne K.P., Wolfe K.H.;
"Evolutionary erosion of yeast sex chromosomes by mating-type
switching accidents.";
Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
-!- FUNCTION: Pyrophosphatase that hydrolyzes non-canonical purine
nucleotides such as inosine triphosphate (ITP), deoxyinosine
triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their
respective monophosphate derivatives. The enzyme does not
distinguish between the deoxy- and ribose forms. Probably excludes
non-canonical purines from RNA and DNA precursor pools, thus
preventing their incorporation into RNA and DNA and avoiding
chromosomal lesions. {ECO:0000256|HAMAP-Rule:MF_03148}.
-!- CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a
nucleotide + diphosphate. {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721545}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721538}.
-!- SIMILARITY: Belongs to the HAM1 NTPase family. {ECO:0000256|HAMAP-
Rule:MF_03148, ECO:0000256|RuleBase:RU003781,
ECO:0000256|SAAS:SAAS00721539}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03148}.
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EMBL; HE616747; CCE92852.1; -; Genomic_DNA.
RefSeq; XP_003682063.1; XM_003682015.1.
STRING; 4950.XP_003682063.1; -.
EnsemblFungi; CCE92852; CCE92852; TDEL_0F00410.
GeneID; 11501154; -.
KEGG; tdl:TDEL_0F00410; -.
InParanoid; G8ZW58; -.
KO; K01519; -.
OrthoDB; EOG092C523G; -.
Proteomes; UP000005627; Chromosome 6.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
GO; GO:0008828; F:dATP pyrophosphohydrolase activity; IEA:EnsemblFungi.
GO; GO:0047840; F:dCTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036217; F:dGTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0035870; F:dITP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036218; F:dTTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0004170; F:dUTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036219; F:GTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036220; F:ITP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0035529; F:NADH pyrophosphatase activity; IEA:UniProtKB-EC.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0036221; F:UTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036222; F:XTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
GO; GO:0009217; P:purine deoxyribonucleoside triphosphate catabolic process; IEA:EnsemblFungi.
GO; GO:0009213; P:pyrimidine deoxyribonucleoside triphosphate catabolic process; IEA:EnsemblFungi.
CDD; cd00515; HAM1; 1.
Gene3D; 3.90.950.10; -; 1.
HAMAP; MF_03148; HAM1_NTPase; 1.
InterPro; IPR002637; Ham1p-like.
InterPro; IPR027502; ITPase.
InterPro; IPR029001; ITPase-like_fam.
PANTHER; PTHR11067; PTHR11067; 1.
Pfam; PF01725; Ham1p_like; 1.
SUPFAM; SSF52972; SSF52972; 1.
TIGRFAMs; TIGR00042; TIGR00042; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000005627};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721512};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|RuleBase:RU003781, ECO:0000256|SAAS:SAAS00721541};
Magnesium {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721547};
Manganese {ECO:0000256|HAMAP-Rule:MF_03148};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721543};
Nucleotide metabolism {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721522};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721527};
Nucleus {ECO:0000256|HAMAP-Rule:MF_03148};
Reference proteome {ECO:0000313|Proteomes:UP000005627}.
REGION 10 15 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_03148}.
REGION 76 77 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_03148}.
REGION 151 154 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_03148}.
METAL 45 45 Magnesium or manganese.
{ECO:0000256|HAMAP-Rule:MF_03148}.
METAL 76 76 Magnesium or manganese.
{ECO:0000256|HAMAP-Rule:MF_03148}.
BINDING 58 58 Substrate. {ECO:0000256|HAMAP-
Rule:MF_03148}.
BINDING 175 175 Substrate. {ECO:0000256|HAMAP-
Rule:MF_03148}.
SEQUENCE 194 AA; 21635 MW; 110E337A67850A86 CRC64;
MAPKEITFIT GNANKLKEVQ MLLAPEASSI EPTFMLVNQE LDLDEVQDTD LEEIAMHKCR
QAASLVGPNK PVFVEDTALC FDEFNGLPGA YIKWFVKSMG LPKIVKMLEP FENKNAQAVT
TIAYADGEGN FHTFQGITRG KIVDSRGPLT FGWDAIFEPL EAQGKTYAEM EKSAKNKISQ
RGRAFAKFKE HLTN


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