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Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)

 K0K902_WICCF            Unreviewed;       191 AA.
K0K902;
28-NOV-2012, integrated into UniProtKB/TrEMBL.
28-NOV-2012, sequence version 1.
27-SEP-2017, entry version 29.
RecName: Full=Inosine triphosphate pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
Short=ITPase {ECO:0000256|HAMAP-Rule:MF_03148};
Short=Inosine triphosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
EC=3.6.1.9 {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Non-canonical purine NTP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Non-standard purine NTP pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate diphosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_03148};
Short=NTPase {ECO:0000256|HAMAP-Rule:MF_03148};
Name=HAM1 {ECO:0000256|HAMAP-Rule:MF_03148};
ORFNames=BN7_879 {ECO:0000313|EMBL:CCH41340.1};
Wickerhamomyces ciferrii (strain F-60-10 / ATCC 14091 / CBS 111 / JCM
3599 / NBRC 0793 / NRRL Y-1031) (Yeast) (Pichia ciferrii).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
NCBI_TaxID=1206466 {ECO:0000313|Proteomes:UP000009328};
[1] {ECO:0000313|EMBL:CCH41340.1, ECO:0000313|Proteomes:UP000009328}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=F-60-10 / ATCC 14091 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL
Y-1031 {ECO:0000313|Proteomes:UP000009328};
PubMed=23193139; DOI=10.1128/EC.00258-12;
Schneider J., Andrea H., Blom J., Jaenicke S., Rueckert C.,
Schorsch C., Szczepanowski R., Farwick M., Goesmann A., Puehler A.,
Schaffer S., Tauch A., Koehler T., Brinkrolf K.;
"Draft genome sequence of Wickerhamomyces ciferrii NRRL Y-1031 F-60-
10.";
Eukaryot. Cell 11:1582-1583(2012).
-!- FUNCTION: Pyrophosphatase that hydrolyzes non-canonical purine
nucleotides such as inosine triphosphate (ITP), deoxyinosine
triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their
respective monophosphate derivatives. The enzyme does not
distinguish between the deoxy- and ribose forms. Probably excludes
non-canonical purines from RNA and DNA precursor pools, thus
preventing their incorporation into RNA and DNA and avoiding
chromosomal lesions. {ECO:0000256|HAMAP-Rule:MF_03148}.
-!- CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a
nucleotide + diphosphate. {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721545}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721538}.
-!- SIMILARITY: Belongs to the HAM1 NTPase family. {ECO:0000256|HAMAP-
Rule:MF_03148, ECO:0000256|SAAS:SAAS00721539}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_03148}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:CCH41340.1}.
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EMBL; CAIF01000017; CCH41340.1; -; Genomic_DNA.
EnsemblFungi; CCH41340; CCH41340; BN7_879.
InParanoid; K0K902; -.
OrthoDB; EOG092C523G; -.
Proteomes; UP000009328; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
GO; GO:0008828; F:dATP pyrophosphohydrolase activity; IEA:EnsemblFungi.
GO; GO:0047840; F:dCTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036217; F:dGTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0035870; F:dITP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036218; F:dTTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0004170; F:dUTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036219; F:GTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036220; F:ITP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0035529; F:NADH pyrophosphatase activity; IEA:UniProtKB-EC.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0036221; F:UTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036222; F:XTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
GO; GO:0009217; P:purine deoxyribonucleoside triphosphate catabolic process; IEA:EnsemblFungi.
GO; GO:0009213; P:pyrimidine deoxyribonucleoside triphosphate catabolic process; IEA:EnsemblFungi.
CDD; cd00515; HAM1; 1.
Gene3D; 3.90.950.10; -; 1.
HAMAP; MF_03148; HAM1_NTPase; 1.
InterPro; IPR002637; Ham1p-like.
InterPro; IPR027502; ITPase.
InterPro; IPR029001; ITPase-like_fam.
PANTHER; PTHR11067; PTHR11067; 1.
Pfam; PF01725; Ham1p_like; 1.
SUPFAM; SSF52972; SSF52972; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000009328};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721512};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721541, ECO:0000313|EMBL:CCH41340.1};
Magnesium {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721547};
Manganese {ECO:0000256|HAMAP-Rule:MF_03148};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721543};
Nucleotide metabolism {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721522};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03148,
ECO:0000256|SAAS:SAAS00721527};
Nucleus {ECO:0000256|HAMAP-Rule:MF_03148};
Reference proteome {ECO:0000313|Proteomes:UP000009328}.
REGION 10 15 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_03148}.
REGION 65 66 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_03148}.
REGION 175 176 Substrate binding. {ECO:0000256|HAMAP-
Rule:MF_03148}.
METAL 37 37 Magnesium or manganese.
{ECO:0000256|HAMAP-Rule:MF_03148}.
METAL 65 65 Magnesium or manganese.
{ECO:0000256|HAMAP-Rule:MF_03148}.
BINDING 49 49 Substrate. {ECO:0000256|HAMAP-
Rule:MF_03148}.
BINDING 170 170 Substrate. {ECO:0000256|HAMAP-
Rule:MF_03148}.
SEQUENCE 191 AA; 21107 MW; C636E31A2FC7832F CRC64;
MSRPAITFVT GNAKKLKEFQ AIIGDDSIKN QSVDLEEIQG SIKDISIKKV TAAAAQIKGP
VLVEDTCLVF SALSKPGIEL PGPYIKWFVD SVGVENLPKL LAGFEDKSAQ TVCTFAFTEG
PGEEIKLFQG ITEGKIVEPR YNGDEVFGFD PIFEPIGFDQ TFGEMDKSLK NTISHRFRAL
EKVKEFLKTR K


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