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Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.9) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase)

 ITPA_KLULA              Reviewed;         194 AA.
Q6CV82;
19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 1.
20-DEC-2017, entry version 81.
RecName: Full=Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=ITPase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=Inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
EC=3.6.1.9 {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
AltName: Full=Nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148};
Short=NTPase {ECO:0000255|HAMAP-Rule:MF_03148};
Name=HAM1 {ECO:0000255|HAMAP-Rule:MF_03148};
OrderedLocusNames=KLLA0B14058g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
-!- FUNCTION: Pyrophosphatase that hydrolyzes non-canonical purine
nucleotides such as inosine triphosphate (ITP), deoxyinosine
triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their
respective monophosphate derivatives. The enzyme does not
distinguish between the deoxy- and ribose forms. Probably excludes
non-canonical purines from RNA and DNA precursor pools, thus
preventing their incorporation into RNA and DNA and avoiding
chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a
nucleotide + diphosphate. {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_03148};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000255|HAMAP-Rule:MF_03148};
Note=Binds 1 divalent metal cation per subunit; can use either
Mg(2+) or Mn(2+). {ECO:0000255|HAMAP-Rule:MF_03148};
-!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148}.
Nucleus {ECO:0000255|HAMAP-Rule:MF_03148}.
-!- SIMILARITY: Belongs to the HAM1 NTPase family. {ECO:0000255|HAMAP-
Rule:MF_03148}.
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EMBL; CR382122; CAH02550.1; -; Genomic_DNA.
RefSeq; XP_452157.1; XM_452157.1.
ProteinModelPortal; Q6CV82; -.
SMR; Q6CV82; -.
STRING; 284590.XP_452157.1; -.
EnsemblFungi; CAH02550; CAH02550; KLLA0_B14058g.
GeneID; 2897035; -.
KEGG; kla:KLLA0B14058g; -.
eggNOG; KOG3222; Eukaryota.
eggNOG; COG0127; LUCA.
HOGENOM; HOG000293320; -.
InParanoid; Q6CV82; -.
KO; K01519; -.
OMA; YDPIFQP; -.
OrthoDB; EOG092C523G; -.
Proteomes; UP000000598; Chromosome B.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0008828; F:dATP pyrophosphohydrolase activity; IEA:EnsemblFungi.
GO; GO:0047840; F:dCTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036217; F:dGTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0035870; F:dITP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036218; F:dTTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0004170; F:dUTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036219; F:GTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036220; F:ITP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0035529; F:NADH pyrophosphatase activity; IEA:UniProtKB-EC.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0036221; F:UTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0036222; F:XTP diphosphatase activity; IEA:EnsemblFungi.
GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProtKB-KW.
GO; GO:0009217; P:purine deoxyribonucleoside triphosphate catabolic process; IEA:EnsemblFungi.
GO; GO:0009213; P:pyrimidine deoxyribonucleoside triphosphate catabolic process; IEA:EnsemblFungi.
CDD; cd00515; HAM1; 1.
Gene3D; 3.90.950.10; -; 1.
HAMAP; MF_03148; HAM1_NTPase; 1.
InterPro; IPR002637; Ham1p-like.
InterPro; IPR027502; ITPase.
InterPro; IPR029001; ITPase-like_fam.
PANTHER; PTHR11067; PTHR11067; 1.
Pfam; PF01725; Ham1p_like; 1.
SUPFAM; SSF52972; SSF52972; 1.
TIGRFAMs; TIGR00042; TIGR00042; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese;
Metal-binding; Nucleotide metabolism; Nucleotide-binding; Nucleus;
Reference proteome.
CHAIN 1 194 Inosine triphosphate pyrophosphatase.
/FTId=PRO_0000413141.
REGION 10 15 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 72 73 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
REGION 147 150 Substrate binding. {ECO:0000255|HAMAP-
Rule:MF_03148}.
METAL 41 41 Magnesium or manganese.
{ECO:0000255|HAMAP-Rule:MF_03148}.
METAL 72 72 Magnesium or manganese.
{ECO:0000255|HAMAP-Rule:MF_03148}.
BINDING 54 54 Substrate. {ECO:0000255|HAMAP-
Rule:MF_03148}.
BINDING 172 172 Substrate. {ECO:0000255|HAMAP-
Rule:MF_03148}.
SEQUENCE 194 AA; 21431 MW; EFAD03FDFA3D13FA CRC64;
MPKPEIVFVT GNANKLREVS MILGGDASPF TLVNEPLDLE ELQGADLQEI ALAKLQQAVH
ALGPGRPVFV EDTALSFDEF NGLPGAYIKW FIKSMGLAKV VKMLDSFENK GAYAITTIAY
ADSKGQLHVF QGKTHGTIVD SRGHTNFGWD SIFQPDESQN NETYAEMAKE DKNKISQRGR
AFAQLKEYLY NTGI


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