Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2)

 VIP2_PONAB              Reviewed;        1244 AA.
Q5REW0;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
10-MAY-2017, entry version 62.
RecName: Full=Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2;
EC=2.7.4.21 {ECO:0000250|UniProtKB:O43314};
EC=2.7.4.24 {ECO:0000250|UniProtKB:O43314};
AltName: Full=Diphosphoinositol pentakisphosphate kinase 2;
AltName: Full=Histidine acid phosphatase domain-containing protein 1;
AltName: Full=InsP6 and PP-IP5 kinase 2;
AltName: Full=VIP1 homolog 2;
Name=PPIP5K2; Synonyms=HISPPD1, VIP2;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Bifunctional inositol kinase that acts in concert with
the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the
diphosphate group-containing inositol pyrophosphates
diphosphoinositol pentakisphosphate, PP-InsP5, and bis-
diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and
(PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a
variety of cellular processes, including apoptosis, vesicle
trafficking, cytoskeletal dynamics, exocytosis, insulin signaling
and neutrophil activation. Phosphorylates inositol
hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5
which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4.
Alternatively, phosphorylates at position 1 or 3 PP-InsP5,
produced by IP6Ks from InsP6, to produce (PP)2-InsP4.
{ECO:0000250|UniProtKB:O43314}.
-!- CATALYTIC ACTIVITY: ATP + 1D-myo-inositol hexakisphosphate = ADP +
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
{ECO:0000250|UniProtKB:O43314}.
-!- CATALYTIC ACTIVITY: ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-
pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate)
2,3,4,6-tetrakisphosphate. {ECO:0000250|UniProtKB:O43314}.
-!- CATALYTIC ACTIVITY: ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-
pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate)
2,3,4,6-tetrakisphosphate. {ECO:0000250|UniProtKB:O43314}.
-!- CATALYTIC ACTIVITY: ATP + 1D-myo-inositol hexakisphosphate = ADP +
1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.
{ECO:0000250|UniProtKB:O43314}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
{ECO:0000250|UniProtKB:O43314}.
-!- DOMAIN: The C-terminal acid phosphatase-like domain binds
PtdIns(3,4,5)P3 and InsP6. Despite its similarity with the
phosphatase domain of histidine acid phosphatases, it has no
phosphatase activity. {ECO:0000250|UniProtKB:O43314}.
-!- SIMILARITY: Belongs to the histidine acid phosphatase family. VIP1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; CR857406; CAH89697.1; -; mRNA.
ProteinModelPortal; Q5REW0; -.
SMR; Q5REW0; -.
HOVERGEN; HBG108657; -.
InParanoid; Q5REW0; -.
Proteomes; UP000001595; Unplaced.
GO; GO:0005829; C:cytosol; ISS:UniProtKB.
GO; GO:0003993; F:acid phosphatase activity; IEA:InterPro.
GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
GO; GO:0033857; F:diphosphoinositol-pentakisphosphate kinase activity; ISS:UniProtKB.
GO; GO:0052723; F:inositol hexakisphosphate 1-kinase activity; IEA:UniProtKB-EC.
GO; GO:0052724; F:inositol hexakisphosphate 3-kinase activity; IEA:UniProtKB-EC.
GO; GO:0000832; F:inositol hexakisphosphate 5-kinase activity; ISS:UniProtKB.
GO; GO:0000827; F:inositol-1,3,4,5,6-pentakisphosphate kinase activity; ISS:UniProtKB.
GO; GO:0006020; P:inositol metabolic process; ISS:UniProtKB.
CDD; cd07061; HP_HAP_like; 1.
Gene3D; 3.40.50.1240; -; 1.
InterPro; IPR033379; Acid_Pase_AS.
InterPro; IPR000560; His_Pase_clade-2.
InterPro; IPR029033; His_PPase_superfam.
Pfam; PF00328; His_Phos_2; 1.
SUPFAM; SSF53254; SSF53254; 3.
PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
2: Evidence at transcript level;
ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
Phosphoprotein; Reference proteome; Transferase.
CHAIN 1 1244 Inositol hexakisphosphate and
diphosphoinositol-pentakisphosphate
kinase 2.
/FTId=PRO_0000315694.
NP_BIND 237 240 ATP. {ECO:0000250|UniProtKB:O43314}.
NP_BIND 246 248 ATP. {ECO:0000250|UniProtKB:O43314}.
NP_BIND 321 323 ATP. {ECO:0000250|UniProtKB:O43314}.
REGION 53 54 Substrate binding.
{ECO:0000250|UniProtKB:O43314}.
REGION 213 214 Substrate binding.
{ECO:0000250|UniProtKB:O43314}.
REGION 326 329 Substrate binding.
{ECO:0000250|UniProtKB:O43314}.
REGION 371 442 Polyphosphoinositide-binding domain.
{ECO:0000250|UniProtKB:O43314}.
BINDING 134 134 ATP. {ECO:0000250|UniProtKB:O43314}.
BINDING 187 187 ATP. {ECO:0000250|UniProtKB:O43314}.
BINDING 194 194 ATP. {ECO:0000250|UniProtKB:O43314}.
BINDING 213 213 ATP. {ECO:0000250|UniProtKB:O43314}.
BINDING 248 248 Substrate.
{ECO:0000250|UniProtKB:O43314}.
BINDING 262 262 Substrate.
{ECO:0000250|UniProtKB:O43314}.
BINDING 264 264 ATP. {ECO:0000250|UniProtKB:O43314}.
BINDING 309 309 ATP. {ECO:0000250|UniProtKB:O43314}.
MOD_RES 38 38 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 223 223 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1007 1007 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1017 1017 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1075 1075 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1092 1092 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1166 1166 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1173 1173 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1181 1181 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1221 1221 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
MOD_RES 1222 1222 Phosphoserine.
{ECO:0000250|UniProtKB:O43314}.
SEQUENCE 1244 AA; 140390 MW; CBB0901E63D33824 CRC64;
MSEAPRFFVG PEDTEINPGN YRHFFHHADE DDEEEDDSPP ERQIVVGICS MAKKSKSKPM
KEILERVSLF KYITVVVFEE EVILNEPVEN WPLCDCLISF HSKGFPLDKA VAYAKLRNPF
VINDLNMQYL IQDRREVYSI LQAEGILLPR YAILNRDPNN PKECNLIEGE DHVEVNGEVF
QKPFVEKPVS AEDHNVYIYY PTSAGGGSQR LFRKIGSRSS VYSPESNVRK TGSYIYEEFM
PTDGTDVKVY TVGPDYAHAE ARKSPALDGK VERDSEGKEV RYPVILNARE KLIAWKVCLA
FKQTVCGFDL LRANGQSYVC DVNGFSFVKN SMKYYDDCAK ILGNIVMREL APQFHIPWSI
PLEAEDIPIV PTTSGTMMEL RCVIAVIRHG DRTPKQKMKM EVRHQKFFDL FEKCDGYKSG
KLKLKKPKQL QEVLDIARQL LMELGQNNDS EIEENKPKLE QLKTVLEMYG HFFSGINRKV
QLTYLPHGCP KTSSEEEDSR REEPSLLLVL KWGGELTPAG RVQAEELGRA FRCMYPGGQG
DYAGFPGCGL LRLHSTYRHD LKIYASDEGR VQMTAAAFAK GLLALEGELT PILVQMVKSA
NMNGLLDSDS DSLSSCQQRV KARLHEILQK DRDFTAEDYE ELTPSGSVSL IKSMHLIKNP
VKTCDKVYSL IQSLTSQIRH RMEDPKSSDI QLYHSETLEL MLRRWSKLEK DFKAKNGRYD
ISKIPDIYDC IKYDVQHNGS LKLENTMELY RLSKALADIV IPQEYGITKA EKLEIAKGYC
TPLVRKIRSD LQRTQDDGTV NKLHPVYSRG VLSPERHVRT RLYFTSESHV HSLLSILRYG
ALCNESKDEQ WKRAMDYLNV VNELNYMTQI VIMLYEDPNK DLSSEERFHV ELHFSPGAKG
CEEDKNLPSG YGYRPASREN EGRRPSKIDN DDEPHTSKRD EVDRAVILFK PMVSEPIHIH
RKSPLPRSRK MATNDEESPL SVSSPEGTGT WLHYTSGVGT GRRRRRSGEQ ITSSPVSPKS
LAFTSSIFGS WQQVVSENAN YLRTPRTLVE QKQNPTVGSH CAGLFSTSVL GGSSSAPNLQ
DYARTHRKKL TSSGCIDDAT RGSAVKRFSI SFARHPTNGF ELYSMVPSIC PLETLHNALS
LKQVDEFLAS IASPSSDVPR KTAEISSTAL HSSPIMRKKV SLNTYTPAKI LPTPPATLKS
TKASSKPATS GPSSAVVPNT SSRKKNITSK TETHEHKKNT GKKK


Related products :

Catalog number Product name Quantity
EIAAB45790 Diphosphoinositol pentakisphosphate kinase 1,Hisppd2a,Histidine acid phosphatase domain-containing protein 2A,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1,InsP6 and PP-IP
EIAAB45789 Diphosphoinositol pentakisphosphate kinase 1,Hisppd2a,Histidine acid phosphatase domain-containing protein 2A,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1,InsP6 and PP-IP
EIAAB45792 Diphosphoinositol pentakisphosphate kinase 2,Hisppd1,Histidine acid phosphatase domain-containing protein 1,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2,InsP6 and PP-IP5
EIAAB45788 Bos taurus,Bovine,Diphosphoinositol pentakisphosphate kinase 1,HISPPD2A,Histidine acid phosphatase domain-containing protein 2A,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
EIAAB45793 Diphosphoinositol pentakisphosphate kinase 2,HISPPD1,Histidine acid phosphatase domain-containing protein 1,Homo sapiens,hsVIP2,Human,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate
EIAAB45791 Diphosphoinositol pentakisphosphate kinase 1,HISPPD2A,Histidine acid phosphatase domain-containing protein 2A,Homo sapiens,hsVIP1,Human,Inositol hexakisphosphate and diphosphoinositol-pentakisphosphat
CSB-EL010373HU Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2(HISPPD1) ELISA kit 96T
CSB-EL010374HU Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1(HISPPD2A) ELISA kit 96T
CSB-EL010373HU Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2(HISPPD1) ELISA kit SpeciesHuman 96T
CSB-EL010374HU Human Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1(HISPPD2A) ELISA kit SpeciesHuman 96T
VIP1_MOUSE ELISA Kit FOR Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; organism: Mouse; gene name: Ppip5k1 96T
VIP2_MOUSE ELISA Kit FOR Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; organism: Mouse; gene name: Ppip5k2 96T
PPL PPIP5K2 Gene diphosphoinositol pentakisphosphate kinase 2
E12626h Human Diphosphoinositol Pentakisphosphate Kinase 2 96T
E12625h Human Diphosphoinositol Pentakisphosphate Kinase 1 96T
PPKB PPIP5K1 Gene diphosphoinositol pentakisphosphate kinase 1
E15053h Rat ELISA Kit FOR Inositol-pentakisphosphate 2-kinase 96T
IQCA1 IPPK Gene inositol 1,3,4,5,6-pentakisphosphate 2-kinase
CSB-EL011783RA Rat Inositol-pentakisphosphate 2-kinase(IPPK) ELISA kit 96T
201-20-2827 IPPK{inositol 1,3,4,5,6-pentakisphosphate 2-kinase}rabbit.pAb 0.2ml
CSB-EL011783HU Human Inositol-pentakisphosphate 2-kinase(IPPK) ELISA kit 96T
CSB-EL011783MO Mouse Inositol-pentakisphosphate 2-kinase(IPPK) ELISA kit 96T
CSB-EL011783RA Rat Inositol-pentakisphosphate 2-kinase(IPPK) ELISA kit SpeciesRat 96T
CSB-EL011783HU Human Inositol-pentakisphosphate 2-kinase(IPPK) ELISA kit SpeciesHuman 96T
CSB-EL011783MO Mouse Inositol-pentakisphosphate 2-kinase(IPPK) ELISA kit SpeciesMouse 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur