Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Inositol-tetrakisphosphate 1-kinase 1 (EC 2.7.1.134) (Inositol 1,3,4-trisphosphate 5/6-kinase 1) (AtItpk-1) (Inositol-triphosphate 5/6-kinase 1) (Ins(1,3,4)P(3) 5/6-kinase 1) (EC 2.7.1.159)

 ITPK1_ARATH             Reviewed;         319 AA.
Q9SBA5; O81633;
06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
05-DEC-2018, entry version 114.
RecName: Full=Inositol-tetrakisphosphate 1-kinase 1;
EC=2.7.1.134 {ECO:0000305};
AltName: Full=Inositol 1,3,4-trisphosphate 5/6-kinase 1;
Short=AtItpk-1;
Short=Inositol-triphosphate 5/6-kinase 1;
Short=Ins(1,3,4)P(3) 5/6-kinase 1;
EC=2.7.1.159 {ECO:0000269|PubMed:9126335};
Name=ITPK1; OrderedLocusNames=At5g16760; ORFNames=F5E19.100;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND ENZYME ACTIVITY.
PubMed=9126335; DOI=10.1006/bbrc.1997.6355;
Wilson M.P., Majerus P.W.;
"Characterization of a cDNA encoding Arabidopsis thaliana inositol
1,3,4-trisphosphate 5/6-kinase.";
Biochem. Biophys. Res. Commun. 232:678-681(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Xue H., Mueller-Roeber B.;
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130714; DOI=10.1038/35048507;
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
"Sequence and analysis of chromosome 5 of the plant Arabidopsis
thaliana.";
Nature 408:823-826(2000).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[7]
DISRUPTION PHENOTYPE.
PubMed=21698461; DOI=10.1007/s00438-011-0631-2;
Kim S.I., Tai T.H.;
"Identification of genes necessary for wild-type levels of seed phytic
acid in Arabidopsis thaliana using a reverse genetics approach.";
Mol. Genet. Genomics 286:119-133(2011).
[8]
ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22223895; DOI=10.1074/mcp.M111.015131;
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C.,
Meinnel T., Giglione C.;
"Comparative large-scale characterisation of plant vs. mammal proteins
reveals similar and idiosyncratic N-alpha acetylation features.";
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
[9]
TISSUE SPECIFICITY.
PubMed=23595027; DOI=10.1093/abbs/gmt039;
Tang Y., Tan S., Xue H.;
"Arabidopsis inositol 1,3,4-trisphosphate 5/6 kinase 2 is required for
seed coat development.";
Acta Biochim. Biophys. Sin. 45:549-560(2013).
-!- FUNCTION: Kinase that can phosphorylate various inositol
polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.
Phosphorylates Ins(3,4,5,6)P4 at position 1 to form
Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory
importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma
membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5
is not (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5
and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the
hexakisphosphate (InsP6) pathway (PubMed:9126335).
{ECO:0000250|UniProtKB:Q13572, ECO:0000269|PubMed:9126335}.
-!- CATALYTIC ACTIVITY:
Reaction=1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-
inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+);
Xref=Rhea:RHEA:12452, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:57539, ChEBI:CHEBI:57733, ChEBI:CHEBI:456216;
EC=2.7.1.134; Evidence={ECO:0000305};
-!- CATALYTIC ACTIVITY:
Reaction=1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-
inositol 1,3,4,5-tetrakisphosphate + ADP + H(+);
Xref=Rhea:RHEA:13253, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:57895, ChEBI:CHEBI:58414, ChEBI:CHEBI:456216;
EC=2.7.1.159; Evidence={ECO:0000305};
-!- CATALYTIC ACTIVITY:
Reaction=1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-
inositol 1,3,4,6-tetrakisphosphate + ADP + H(+);
Xref=Rhea:RHEA:20940, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:57660, ChEBI:CHEBI:58414, ChEBI:CHEBI:456216;
EC=2.7.1.159; Evidence={ECO:0000269|PubMed:9126335};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000250|UniProtKB:Q13572};
Note=Binds 2 magnesium ions per subunit.
{ECO:0000250|UniProtKB:Q13572};
-!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q13572}.
-!- TISSUE SPECIFICITY: Expressed in siliques.
{ECO:0000269|PubMed:23595027}.
-!- DISRUPTION PHENOTYPE: Low inositol hexakisphosphate (phytate)
levels in seed tissue. {ECO:0000269|PubMed:21698461}.
-!- SIMILARITY: Belongs to the ITPK1 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF080173; AAC28859.1; -; mRNA.
EMBL; AJ001753; CAA04976.1; -; mRNA.
EMBL; AL391147; CAC01840.1; -; Genomic_DNA.
EMBL; CP002688; AED92334.1; -; Genomic_DNA.
EMBL; AY072156; AAL59978.1; -; mRNA.
EMBL; AY096412; AAM20052.1; -; mRNA.
EMBL; AY087024; AAM64585.1; -; mRNA.
PIR; JC5401; JC5401.
RefSeq; NP_197178.1; NM_121682.3.
UniGene; At.5370; -.
ProteinModelPortal; Q9SBA5; -.
STRING; 3702.AT5G16760.1; -.
iPTMnet; Q9SBA5; -.
PaxDb; Q9SBA5; -.
PRIDE; Q9SBA5; -.
DNASU; 831539; -.
EnsemblPlants; AT5G16760.1; AT5G16760.1; AT5G16760.
GeneID; 831539; -.
Gramene; AT5G16760.1; AT5G16760.1; AT5G16760.
KEGG; ath:AT5G16760; -.
Araport; AT5G16760; -.
TAIR; locus:2148990; AT5G16760.
eggNOG; ENOG410IHA6; Eukaryota.
eggNOG; ENOG4110KIK; LUCA.
HOGENOM; HOG000220790; -.
InParanoid; Q9SBA5; -.
KO; K00913; -.
OMA; MQDERIC; -.
OrthoDB; EOG09360FFG; -.
PhylomeDB; Q9SBA5; -.
BioCyc; ARA:AT5G16760-MONOMER; -.
BioCyc; MetaCyc:AT5G16760-MONOMER; -.
BRENDA; 2.7.1.159; 399.
Reactome; R-ATH-1855167; Synthesis of pyrophosphates in the cytosol.
Reactome; R-ATH-1855204; Synthesis of IP3 and IP4 in the cytosol.
Reactome; R-ATH-983231; Factors involved in megakaryocyte development and platelet production.
PRO; PR:Q9SBA5; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; Q9SBA5; baseline and differential.
Genevisible; Q9SBA5; AT.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:TAIR.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0047325; F:inositol tetrakisphosphate 1-kinase activity; IBA:GO_Central.
GO; GO:0052726; F:inositol-1,3,4-trisphosphate 5-kinase activity; IDA:TAIR.
GO; GO:0052725; F:inositol-1,3,4-trisphosphate 6-kinase activity; IDA:TAIR.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0052746; P:inositol phosphorylation; IDA:TAIR.
GO; GO:0032957; P:inositol trisphosphate metabolic process; IEA:InterPro.
GO; GO:0010264; P:myo-inositol hexakisphosphate biosynthetic process; IMP:TAIR.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR008656; Inositol_tetrakis-P_1-kinase.
PANTHER; PTHR14217; PTHR14217; 1.
PIRSF; PIRSF038186; ITPK; 1.
PROSITE; PS50975; ATP_GRASP; 1.
1: Evidence at protein level;
Acetylation; ATP-binding; Complete proteome; Kinase; Magnesium;
Metal-binding; Nucleotide-binding; Reference proteome; Transferase.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22223895}.
CHAIN 2 319 Inositol-tetrakisphosphate 1-kinase 1.
/FTId=PRO_0000220839.
DOMAIN 99 318 ATP-grasp. {ECO:0000255|PROSITE-
ProRule:PRU00409}.
NP_BIND 177 188 ATP. {ECO:0000250|UniProtKB:Q13572}.
METAL 273 273 Magnesium 1.
{ECO:0000250|UniProtKB:Q13572}.
METAL 288 288 Magnesium 1.
{ECO:0000250|UniProtKB:Q13572}.
METAL 288 288 Magnesium 2.
{ECO:0000250|UniProtKB:Q13572}.
METAL 290 290 Magnesium 2.
{ECO:0000250|UniProtKB:Q13572}.
BINDING 18 18 1D-myo-inositol 1,3,4-trisphosphate.
{ECO:0000250|UniProtKB:Q9XYQ1}.
BINDING 60 60 1D-myo-inositol 1,3,4-trisphosphate.
{ECO:0000250|UniProtKB:Q9XYQ1}.
BINDING 95 95 ATP. {ECO:0000250|UniProtKB:Q13572}.
BINDING 145 145 ATP. {ECO:0000250|UniProtKB:Q13572}.
BINDING 156 156 1D-myo-inositol 1,3,4-trisphosphate.
{ECO:0000250|UniProtKB:Q9XYQ1}.
BINDING 188 188 1D-myo-inositol 1,3,4-trisphosphate.
{ECO:0000250|UniProtKB:Q9XYQ1}.
BINDING 203 203 ATP. {ECO:0000250|UniProtKB:Q13572}.
BINDING 290 290 1D-myo-inositol 1,3,4-trisphosphate.
{ECO:0000250|UniProtKB:Q9XYQ1}.
MOD_RES 2 2 N-acetylserine.
{ECO:0000244|PubMed:22223895}.
CONFLICT 197 197 K -> Q (in Ref. 1; AAC28859).
{ECO:0000305}.
SEQUENCE 319 AA; 36220 MW; C5EE6F3E55288D1B CRC64;
MSDSIQERYL VGYALAAKKQ HSFIQPSLIE HSRQRGIDLV KLDPTKSLLE QGKLDCIIHK
LYDVYWKENL HEFREKCPGV PVIDLPEAIE RLHNRVSMLE VITQLRFPVS DSERFGVPEQ
VVVMDSSVLS GGGALGELKF PVIAKPLDAD GSAKSHKMFL IYDQEGMKIL KAPIVLQEFV
NHGGVIFKVY VVGDHVKCVK RRSLPDISEE KIGTSKGSLP FSQISNLTAQ EDKNIEYGED
RSLEKVEMPP LSFLTDLAKA MRESMGLNLF NFDVIRDAKD ANRYLIIDIN YFPGYAKMPS
YEPVLTEFFW DMVTKKNHV


Related products :

Catalog number Product name Quantity
pka-040 Recombinant Human Inositol-Tetrakisphosphate 1-Kinase 5
pka-040 Recombinant Human Inositol-Tetrakisphosphate 1-Kinase 1mg
RPK-040 Recombinant Human Inositol-Tetrakisphosphate 1-Kinase 5
pka-040 Recombinant Human Inositol-Tetrakisphosphate 1-Kinase 20
ITPK1_MOUSE Mouse ELISA Kit FOR Inositol-tetrakisphosphate 1-kinase 96T
CSB-EL011908CH Chicken Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit 96T
CSB-EL011908MO Mouse Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit 96T
pka-040 Recombinant Human Inositol-Tetrakisphosphate 1-Kinase PROTEIN KINASES 1mg
CSB-EL011908BO Bovine Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit 96T
pka-040 Recombinant Human Inositol-Tetrakisphosphate 1-Kinase PROTEIN KINASES 5
CSB-EL011908HU Human Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit 96T
pka-040 Recombinant Human Inositol-Tetrakisphosphate 1-Kinase PROTEIN KINASES 20
26-957 ITPK1 is the kinase that can phosphorylate various inositol polyphosphate such as Ins (3,4,5,6)P4 or Ins (1,3,4)P3. It may also act as an isomerase that interconverts the inositol tetraphosphate isome 0.05 mg
CSB-EL011908CH Chicken Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit SpeciesChicken 96T
CSB-EL011908HU Human Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit SpeciesHuman 96T
CSB-EL011908BO Bovine Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit SpeciesBovine 96T
CSB-EL011908MO Mouse Inositol-tetrakisphosphate 1-kinase(ITPK1) ELISA kit SpeciesMouse 96T
ITPK1_MOUSE ELISA Kit FOR Inositol-tetrakisphosphate 1-kinase; organism: Mouse; gene name: Itpk1 96T
CSB-EL011909RA Rat Inositol-trisphosphate 3-kinase A(ITPKA) ELISA kit 96T
E15032m Mouse ELISA Kit FOR Inositol-trisphosphate 3-kinase A 96T
201-20-2867 ITPKC{inositol 1,4,5-trisphosphate 3-kinase C}rabbit.pAb 0.2ml
201-20-2866 ITPKB{inositol 1,4,5-trisphosphate 3-kinase B}rabbit.pAb 0.2ml
CSB-EL011911RA Rat Inositol-trisphosphate 3-kinase C(ITPKC) ELISA kit 96T
ITPR2 ITPKC Gene inositol 1,4,5-trisphosphate 3-kinase C
ITPR1 ITPKB Gene inositol 1,4,5-trisphosphate 3-kinase B


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur