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Insulin gene enhancer protein ISL-1 (Islet-1)

 ISL1_CHICK              Reviewed;         349 AA.
P50211;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
22-NOV-2017, entry version 116.
RecName: Full=Insulin gene enhancer protein ISL-1;
Short=Islet-1 {ECO:0000303|PubMed:7528105};
Name=ISL1; Synonyms=ISL-1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
TISSUE=Spinal cord;
PubMed=7528105; DOI=10.1016/0092-8674(94)90027-2;
Tsuchida T., Ensini M., Morton S.B., Baldassare M., Edlund T.,
Jessell T.M., Pfaff S.L.;
"Topographic organization of embryonic motor neurons defined by
expression of LIM homeobox genes.";
Cell 79:957-970(1994).
-!- FUNCTION: Acts as a transcriptional regulator (PubMed:7528105).
Recognizes and binds to the consensus octamer binding site 5'-
ATAATTAA-3' in promoter of target genes. Plays a fundamental role
in the gene regulatory network essential for retinal ganglion cell
(RGC) differentiation. Binds to insulin gene enhancer sequences
(By similarity). Defines subclasses of motoneurons that segregate
into columns in the spinal cord and select distinct axon pathways
(PubMed:7528105). Acts in conjunction with LHX1, LHX3 and ISL2
(PubMed:7528105). Binds to insulin gene enhancer sequences (By
similarity). Essential for heart development (By similarity).
{ECO:0000250|UniProtKB:P61372, ECO:0000250|UniProtKB:P61374,
ECO:0000269|PubMed:7528105}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61372}.
-!- DEVELOPMENTAL STAGE: Expressed in motor neurons between stages 34
and 35 (at protein level). Expressed prior to the formation of
distinct motor axon pathways and before the segregation of motor
neurons into columns. Expressed throughout the median motor column
and the medial subdivision of the lateral motor column (LMCm).
{ECO:0000269|PubMed:7528105}.
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EMBL; L35567; AAA62171.1; -; mRNA.
PIR; I50369; I50369.
RefSeq; NP_990745.1; NM_205414.1.
UniGene; Gga.1507; -.
ProteinModelPortal; P50211; -.
SMR; P50211; -.
Ensembl; ENSGALT00000038907; ENSGALP00000038117; ENSGALG00000014884.
Ensembl; ENSGALT00000044538; ENSGALP00000043151; ENSGALG00000014884.
GeneID; 396383; -.
KEGG; gga:396383; -.
CTD; 3670; -.
GeneTree; ENSGT00760000118921; -.
HOVERGEN; HBG004671; -.
InParanoid; P50211; -.
KO; K09370; -.
OMA; RIHDQWI; -.
OrthoDB; EOG091G09L9; -.
PhylomeDB; P50211; -.
PRO; PR:P50211; -.
Proteomes; UP000000539; Chromosome Z.
Bgee; ENSGALG00000014884; -.
GO; GO:0005623; C:cell; IDA:AgBase.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IEA:Ensembl.
GO; GO:0001105; F:RNA polymerase II transcription coactivator activity; IEA:Ensembl.
GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl.
GO; GO:0060913; P:cardiac cell fate determination; IEA:Ensembl.
GO; GO:0060379; P:cardiac muscle cell myoblast differentiation; IEA:Ensembl.
GO; GO:0003215; P:cardiac right ventricle morphogenesis; IEA:Ensembl.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0007507; P:heart development; ISS:UniProtKB.
GO; GO:0060384; P:innervation; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEA:Ensembl.
GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; IEA:Ensembl.
GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0045597; P:positive regulation of cell differentiation; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0043388; P:positive regulation of DNA binding; IEA:Ensembl.
GO; GO:0071657; P:positive regulation of granulocyte colony-stimulating factor production; IEA:Ensembl.
GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
GO; GO:0035066; P:positive regulation of histone acetylation; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; IEA:Ensembl.
GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
GO; GO:0003266; P:regulation of secondary heart field cardioblast proliferation; IEA:Ensembl.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
GO; GO:0048880; P:sensory system development; IEA:Ensembl.
GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Ensembl.
GO; GO:0021559; P:trigeminal nerve development; IEA:Ensembl.
GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0021524; P:visceral motor neuron differentiation; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR001781; Znf_LIM.
Pfam; PF00046; Homeobox; 1.
Pfam; PF00412; LIM; 2.
SMART; SM00389; HOX; 1.
SMART; SM00132; LIM; 2.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS00478; LIM_DOMAIN_1; 2.
PROSITE; PS50023; LIM_DOMAIN_2; 2.
1: Evidence at protein level;
Activator; Complete proteome; Developmental protein; Differentiation;
DNA-binding; Homeobox; LIM domain; Metal-binding; Nucleus;
Reference proteome; Repeat; Transcription; Transcription regulation;
Zinc.
CHAIN 1 349 Insulin gene enhancer protein ISL-1.
/FTId=PRO_0000075750.
DOMAIN 17 70 LIM zinc-binding 1. {ECO:0000255|PROSITE-
ProRule:PRU00125}.
DOMAIN 79 133 LIM zinc-binding 2. {ECO:0000255|PROSITE-
ProRule:PRU00125}.
DNA_BIND 181 240 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 241 349 Gln-rich.
SEQUENCE 349 AA; 39034 MW; 286E2B364EE0A505 CRC64;
MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDETCTCFV
RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARAKVY HIECFRCVAC SRQLIPGDEF
ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK
TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS
IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA


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