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Insulin-like growth factor I

 A1X594_PARLE            Unreviewed;       186 AA.
A1X594;
06-FEB-2007, integrated into UniProtKB/TrEMBL.
06-FEB-2007, sequence version 1.
18-JUL-2018, entry version 52.
SubName: Full=Insulin-like growth factor I {ECO:0000313|EMBL:ABB70043.1};
Name=IGF-I {ECO:0000313|EMBL:ABB70043.1};
Paralichthys lethostigma (Southern flounder).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
Paralichthys.
NCBI_TaxID=141886 {ECO:0000313|EMBL:ABB70043.1};
[1] {ECO:0000313|EMBL:ABB70043.1}
NUCLEOTIDE SEQUENCE.
Ueda A., Luckenbach J.A., Daniels H.V., Borski R.J.;
"Growth and its regulation through insulin-like growth factor-I of
southern flounder (Paralichthys lethostigma) subjected to fasting or
different ambient calcium levels.";
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:ABB70043.1}
NUCLEOTIDE SEQUENCE.
PubMed=17116416; DOI=10.1016/j.cbpa.2006.09.024;
Luckenbach J.A., Murashige R., Daniels H.V., Godwin J., Borski R.J.;
"Temperature affects insulin-like growth factor I and growth of
juvenile southern flounder, Paralichthys lethostigma.";
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
146:95-104(2007).
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406,
ECO:0000256|SAAS:SAAS00822014}.
-!- SIMILARITY: Belongs to the insulin family.
{ECO:0000256|RuleBase:RU000406, ECO:0000256|SAAS:SAAS00542063}.
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EMBL; DQ221741; ABB70043.1; -; mRNA.
ProteinModelPortal; A1X594; -.
HOVERGEN; HBG006137; -.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:InterPro.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
InterPro; IPR022341; IGF-I.
InterPro; IPR016179; Insulin-like.
InterPro; IPR022350; Insulin-like_growth_factor.
InterPro; IPR036438; Insulin-like_sf.
InterPro; IPR022353; Insulin_CS.
InterPro; IPR022352; Insulin_family.
Pfam; PF00049; Insulin; 2.
PRINTS; PR02002; INSLNLIKEGF.
PRINTS; PR02005; INSLNLIKEGF1.
PRINTS; PR00276; INSULINFAMLY.
SMART; SM00078; IlGF; 1.
SUPFAM; SSF56994; SSF56994; 1.
PROSITE; PS00262; INSULIN; 1.
2: Evidence at transcript level;
Secreted {ECO:0000256|RuleBase:RU000406,
ECO:0000256|SAAS:SAAS00822033}; Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 43 {ECO:0000256|SAM:SignalP}.
CHAIN 44 186 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5002640632.
DOMAIN 47 103 IlGF. {ECO:0000259|SMART:SM00078}.
SEQUENCE 186 AA; 20533 MW; 440819048A831B92 CRC64;
MSSALSFQWH LCDVFKSAMC CTSCSHTLSL LLCVLTLTPT ATGAGPETLC GAELVDTLQF
VCGERGFYFS KPTGYGPNAR RSRGIVDECC FQSCELRRLE MYCAPAKTSK AARSVRAQRH
TDMPRAPKVS TAGHKVDKGT ERRTAQQPDK TKNKKRPLPG HSHSSFKEVH QKNSSRGNTG
GRNYRM


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