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Insulin-like growth factor I (IGF-I) (Somatomedin)

 IGF1_ONCKI              Reviewed;         188 AA.
P17085; P81268; Q6LDG9; Q91161; Q91162; Q91475;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
19-JUL-2004, sequence version 2.
25-OCT-2017, entry version 90.
RecName: Full=Insulin-like growth factor I;
Short=IGF-I;
AltName: Full=Somatomedin;
Flags: Precursor;
Name=igf1;
Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
NCBI_TaxID=8019;
[1]
NUCLEOTIDE SEQUENCE (ISOFORM 2).
TISSUE=Liver;
PubMed=2628735; DOI=10.1210/mend-3-12-2005;
Cao Q.-P., Duguay S.J., Plisetskaya E.M., Steiner D.F., Chan S.J.;
"Nucleotide sequence and growth hormone-regulated expression of salmon
insulin-like growth factor I mRNA.";
Mol. Endocrinol. 3:2005-2010(1989).
[2]
NUCLEOTIDE SEQUENCE (ISOFORM 3).
PubMed=8024699; DOI=10.1089/dna.1994.13.555;
Kavsan V.M., Grebenjuk V.A., Koval A.P., Skorokhod A.S.,
Roberts C.T. Jr., Leroith D.;
"Isolation of a second nonallelic insulin-like growth factor I gene
from the salmon genome.";
DNA Cell Biol. 13:555-559(1994).
[3]
NUCLEOTIDE SEQUENCE (ISOFORM 3).
Grebenjuk V.A., Skorokhod A.S., Anoprienko O.V., Koval A.P.;
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE OF 27-169 (ISOFORMS 1; 2 AND 3).
TISSUE=Liver;
PubMed=1406698; DOI=10.1210/mend.6.8.1406698;
Duguay S.J., Park L.K., Samadpour M., Dickhoff W.W.;
"Nucleotide sequence and tissue distribution of three insulin-like
growth factor I prohormones in salmon.";
Mol. Endocrinol. 6:1202-1210(1992).
[5]
PROTEIN SEQUENCE OF 45-114.
PubMed=8243465; DOI=10.1111/j.1432-1033.1993.tb18366.x;
Moriyama S., Duguay S.J., Conlon J.M., Duan C., Dickhoff W.W.,
Plisetskaya E.M.;
"Recombinant coho salmon insulin-like growth factor I. Expression in
Escherichia coli, purification and characterization.";
Eur. J. Biochem. 218:205-211(1993).
-!- FUNCTION: The insulin-like growth factors, isolated from plasma,
are structurally and functionally related to insulin but have a
much higher growth-promoting activity. Acts as a ligand for IGF1R.
Binds to the alpha subunit of IGF1R, leading to the activation of
the intrinsic tyrosine kinase activity which autophosphorylates
tyrosine residues in the beta subunit thus initiatiating a cascade
of down-stream signaling events leading to activation of the PI3K-
AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding
to integrins and subsequent ternary complex formation with
integrins and IGFR1 are essential for IGF1 signaling.
{ECO:0000250|UniProtKB:P05019}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=3; Synonyms=Ea-3;
IsoId=P17085-1; Sequence=Displayed;
Name=1; Synonyms=Ea-1;
IsoId=P17085-2; Sequence=VSP_010979;
Name=2; Synonyms=Ea-2;
IsoId=P17085-3; Sequence=VSP_010980;
-!- TISSUE SPECIFICITY: All the isoforms are expressed in embryos,
juvenile and adult liver, muscle and brain. At least one isoform
is expressed in heart, kidney, testes, ovary, adipose tissue and
spleen of juvenile salmon.
-!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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EMBL; M32792; AAA49410.1; -; mRNA.
EMBL; AF063216; AAC18833.1; -; Genomic_DNA.
EMBL; M81911; AAB59947.1; -; mRNA.
EMBL; M81912; AAB59948.1; -; mRNA.
EMBL; M81913; AAA49413.1; -; mRNA.
EMBL; M81904; AAA18211.1; -; mRNA.
PIR; A41396; A41396.
PIR; C44012; C44012.
UniGene; Ssa.40; -.
ProteinModelPortal; P17085; -.
SMR; P17085; -.
HOVERGEN; HBG006137; -.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
Gene3D; 1.10.100.10; -; 1.
InterPro; IPR022341; IGF-I.
InterPro; IPR016179; Insulin-like.
InterPro; IPR022350; Insulin-like_growth_factor.
InterPro; IPR036438; Insulin-like_sf.
InterPro; IPR022353; Insulin_CS.
InterPro; IPR022352; Insulin_family.
Pfam; PF00049; Insulin; 1.
PRINTS; PR02002; INSLNLIKEGF.
PRINTS; PR02005; INSLNLIKEGF1.
PRINTS; PR00276; INSULINFAMLY.
SMART; SM00078; IlGF; 1.
SUPFAM; SSF56994; SSF56994; 1.
PROSITE; PS00262; INSULIN; 1.
1: Evidence at protein level;
Alternative splicing; Direct protein sequencing; Disulfide bond;
Growth factor; Secreted; Signal.
SIGNAL 1 ?
PROPEP ? 44 {ECO:0000269|PubMed:8243465}.
/FTId=PRO_0000015702.
CHAIN 45 114 Insulin-like growth factor I.
/FTId=PRO_0000015703.
PROPEP 115 188 E peptide.
/FTId=PRO_0000015704.
REGION 45 73 B.
REGION 74 85 C.
REGION 86 106 A.
REGION 107 114 D.
DISULFID 50 92 {ECO:0000250}.
DISULFID 62 105 {ECO:0000250}.
DISULFID 91 96 {ECO:0000250}.
VAR_SEQ 131 169 Missing (in isoform 1). {ECO:0000305}.
/FTId=VSP_010979.
VAR_SEQ 158 169 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_010980.
CONFLICT 6 6 L -> F (in Ref. 2 and 3). {ECO:0000305}.
CONFLICT 22 22 I -> V (in Ref. 2 and 3). {ECO:0000305}.
CONFLICT 131 131 V -> I (in Ref. 2 and 3). {ECO:0000305}.
CONFLICT 155 155 P -> T (in Ref. 4; AAA18211).
{ECO:0000305}.
CONFLICT 163 163 N -> H (in Ref. 4; AAA18211).
{ECO:0000305}.
SEQUENCE 188 AA; 20758 MW; 76253FA958328B00 CRC64;
MSSGHLFQWH LCDVFKSAMC CISCTHTLSL LLCVLTLTSA ATGAGPETLC GAELVDTLQF
VCGERGFYFS KPTGYGPSSR RSHNRGIVDE CCFQSCELRR LEMYCAPVKS GKAARSVRAQ
RHTDMPRTPK VSTAVQNVDR GTERRTAQHP DKTKPKKKPL SGNSHTSCKE VHQKNSSRGN
TGGRNYRM


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