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Insulin-like growth factor I (IGF-I) (Somatomedin)

 IGF1_CHICK              Reviewed;         153 AA.
P18254;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 1.
28-MAR-2018, entry version 137.
RecName: Full=Insulin-like growth factor I;
Short=IGF-I;
AltName: Full=Somatomedin;
Flags: Precursor;
Name=IGF1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2628728; DOI=10.1210/mend-3-12-1907;
Kajimoto Y., Rotwein P.;
"Structure and expression of a chicken insulin-like growth factor I
precursor.";
Mol. Endocrinol. 3:1907-1913(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
PubMed=2033062;
Rotwein P., Kajimoto Y.;
"Structure of the chicken insulin-like growth factor I gene reveals
conserved promoter elements.";
J. Biol. Chem. 266:9724-9731(1991).
[3]
PROTEIN SEQUENCE OF 49-118.
PubMed=2272467; DOI=10.1016/0016-6480(90)90076-X;
Ballard F.J., Johnson R.J., Owens P.C., Francis G.L., Upton F.M.,
McMurtry J.P., Wallace J.C.;
"Chicken insulin-like growth factor-I: amino acid sequence,
radioimmunoassay, and plasma levels between strains and during
growth.";
Gen. Comp. Endocrinol. 79:459-468(1990).
-!- FUNCTION: The insulin-like growth factors, isolated from plasma,
are structurally and functionally related to insulin but have a
much higher growth-promoting activity. Acts as a ligand for IGF1R.
Binds to the alpha subunit of IGF1R, leading to the activation of
the intrinsic tyrosine kinase activity which autophosphorylates
tyrosine residues in the beta subunit thus initiatiating a cascade
of down-stream signaling events leading to activation of the PI3K-
AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding
to integrins and subsequent ternary complex formation with
integrins and IGFR1 are essential for IGF1 signaling.
{ECO:0000250|UniProtKB:P05019}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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EMBL; M32791; AAA48828.1; -; mRNA.
EMBL; M74176; AAA48829.1; -; Genomic_DNA.
PIR; A41399; A41399.
RefSeq; NP_001004384.1; NM_001004384.2.
UniGene; Gga.850; -.
ProteinModelPortal; P18254; -.
SMR; P18254; -.
STRING; 9031.ENSGALP00000020787; -.
PaxDb; P18254; -.
Ensembl; ENSGALT00000020816; ENSGALP00000020787; ENSGALG00000012755.
GeneID; 418090; -.
KEGG; gga:418090; -.
CTD; 3479; -.
eggNOG; ENOG410IJ2T; Eukaryota.
eggNOG; ENOG4111MIV; LUCA.
GeneTree; ENSGT00530000063856; -.
HOGENOM; HOG000233362; -.
HOVERGEN; HBG006137; -.
InParanoid; P18254; -.
KO; K05459; -.
OMA; CFQSCDL; -.
OrthoDB; EOG091G0H56; -.
PhylomeDB; P18254; -.
TreeFam; TF332820; -.
Reactome; R-GGA-114608; Platelet degranulation.
Reactome; R-GGA-2404192; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
Reactome; R-GGA-2428928; IRS-related events triggered by IGF1R.
Reactome; R-GGA-2428933; SHC-related events triggered by IGF1R.
Reactome; R-GGA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-GGA-422085; Synthesis, secretion, and deacylation of Ghrelin.
PRO; PR:P18254; -.
Proteomes; UP000000539; Chromosome 1.
Bgee; ENSGALG00000012755; -.
ExpressionAtlas; P18254; baseline and differential.
GO; GO:0035867; C:alphav-beta3 integrin-IGF-1-IGF1R complex; IEA:Ensembl.
GO; GO:0005623; C:cell; IDA:AgBase.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0042567; C:insulin-like growth factor ternary complex; IEA:Ensembl.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IEA:Ensembl.
GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:AgBase.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl.
GO; GO:0035630; P:bone mineralization involved in bone maturation; IEA:Ensembl.
GO; GO:0001775; P:cell activation; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IDA:AgBase.
GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
GO; GO:0090103; P:cochlea morphogenesis; IMP:AgBase.
GO; GO:0061560; P:cranial ganglion formation; IMP:AgBase.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010467; P:gene expression; IDA:AgBase.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0014896; P:muscle hypertrophy; IEA:Ensembl.
GO; GO:0045445; P:myoblast differentiation; IEA:Ensembl.
GO; GO:0051450; P:myoblast proliferation; IEA:Ensembl.
GO; GO:0014904; P:myotube cell development; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0046676; P:negative regulation of insulin secretion; IDA:AgBase.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IMP:AgBase.
GO; GO:0060283; P:negative regulation of oocyte development; IEA:Ensembl.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
GO; GO:1905460; P:negative regulation of vascular associated smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0007405; P:neuroblast proliferation; IMP:AgBase.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
GO; GO:0061051; P:positive regulation of cell growth involved in cardiac muscle cell development; IEA:Ensembl.
GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IEA:Ensembl.
GO; GO:0045821; P:positive regulation of glycolytic process; IEA:Ensembl.
GO; GO:0010560; P:positive regulation of glycoprotein biosynthetic process; IEA:Ensembl.
GO; GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0090277; P:positive regulation of peptide hormone secretion; IDA:AgBase.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0045732; P:positive regulation of protein catabolic process; IDA:AgBase.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0050714; P:positive regulation of protein secretion; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IEA:Ensembl.
GO; GO:1904075; P:positive regulation of trophectodermal cell proliferation; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0030166; P:proteoglycan biosynthetic process; IEA:Ensembl.
GO; GO:0040014; P:regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0009408; P:response to heat; IDA:AgBase.
GO; GO:1990418; P:response to insulin-like growth factor stimulus; IDA:AgBase.
GO; GO:0014834; P:skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; IEA:Ensembl.
GO; GO:0021650; P:vestibulocochlear nerve formation; IMP:AgBase.
InterPro; IPR022341; IGF-I.
InterPro; IPR016179; Insulin-like.
InterPro; IPR022350; Insulin-like_growth_factor.
InterPro; IPR036438; Insulin-like_sf.
InterPro; IPR022353; Insulin_CS.
InterPro; IPR022352; Insulin_family.
Pfam; PF00049; Insulin; 1.
PRINTS; PR02002; INSLNLIKEGF.
PRINTS; PR02005; INSLNLIKEGF1.
PRINTS; PR00276; INSULINFAMLY.
SMART; SM00078; IlGF; 1.
SUPFAM; SSF56994; SSF56994; 1.
PROSITE; PS00262; INSULIN; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 ?
PROPEP ? 48 {ECO:0000269|PubMed:2272467}.
/FTId=PRO_0000015690.
CHAIN 49 118 Insulin-like growth factor I.
/FTId=PRO_0000015691.
PROPEP 119 153 E peptide.
/FTId=PRO_0000015692.
REGION 49 77 B.
REGION 78 89 C.
REGION 90 110 A.
REGION 111 118 D.
DISULFID 54 96 {ECO:0000250}.
DISULFID 66 109 {ECO:0000250}.
DISULFID 95 100 {ECO:0000250}.
SEQUENCE 153 AA; 17267 MW; AAE13FDED13EE2F8 CRC64;
MEKINSLSTQ LVKCCFCDFL KVKMHTVSYI HFFYLGLCLL TLTSSAAAGP ETLCGAELVD
ALQFVCGDRG FYFSKPTGYG SSSRRLHHKG IVDECCFQSC DLRRLEMYCA PIKPPKSARS
VRAQRHTDMP KAQKEVHLKN TSRGNTGNRN YRM


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